Zobrazeno 1 - 10
of 354
pro vyhledávání: '"Christophe Le Tourneau"'
Autor:
Nicolas Jacquin, Ronan Flippot, Julien Masliah-Planchon, Guillaume Grisay, Riwan Brillet, Célia Dupain, Maud Kamal, Isabelle Guillou, Nadège Gruel, Nicolas Servant, Pierre Gestraud, Jennifer Wong, Vincent Cockenpot, Andreia Goncalves, Janick Selves, Hélène Blons, Etienne Rouleau, Olivier Delattre, Claire Gervais, Christophe Le Tourneau, Ivan Bièche, Yves Allory, Laurence Albigès, Sarah Watson
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-6 (2024)
Abstract Metastatic carcinoma of presumed renal origin (rCUP) has recently emerged as a new entity within the heterogeneous entity of Cancers of Unknown Primary (CUP) but their biological features and optimal therapeutic management remain unknown. We
Externí odkaz:
https://doaj.org/article/8884285fa1394307af735d86552e3c29
Autor:
Monika Licaj, Rana Mhaidly, Yann Kieffer, Hugo Croizer, Claire Bonneau, Arnaud Meng, Lounes Djerroudi, Kevin Mujangi-Ebeka, Hocine R. Hocine, Brigitte Bourachot, Ilaria Magagna, Renaud Leclere, Lea Guyonnet, Mylene Bohec, Coralie Guérin, Sylvain Baulande, Maud Kamal, Christophe Le Tourneau, Fabrice Lecuru, Véronique Becette, Roman Rouzier, Anne Vincent-Salomon, Geraldine Gentric, Fatima Mechta-Grigoriou
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-27 (2024)
Abstract Although cancer-associated fibroblast (CAF) heterogeneity is well-established, the impact of chemotherapy on CAF populations remains poorly understood. Here we address this question in high-grade serous ovarian cancer (HGSOC), in which we pr
Externí odkaz:
https://doaj.org/article/5ce2555834964b0cb11b2617325ec643
Autor:
Célia Dupain, Tom Gutman, Elodie Girard, Choumouss Kamoun, Grégoire Marret, Zahra Castel-Ajgal, Marie-Paule Sablin, Cindy Neuzillet, Edith Borcoman, Ségolène Hescot, Céline Callens, Olfa Trabelsi-Grati, Samia Melaabi, Roseline Vibert, Samantha Antonio, Coralie Franck, Michèle Galut, Isabelle Guillou, Maral Halladjian, Yves Allory, Joanna Cyrta, Julien Romejon, Eleonore Frouin, Dominique Stoppa-Lyonnet, Jennifer Wong, Christophe Le Tourneau, Ivan Bièche, Nicolas Servant, Maud Kamal, Julien Masliah-Planchon
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-12 (2024)
Abstract Background High tumor mutational burden (TMB) was reported to predict the efficacy of immune checkpoint inhibitors (ICIs). Pembrolizumab, an anti-PD-1, received FDA-approval for the treatment of unresectable/metastatic tumors with high TMB a
Externí odkaz:
https://doaj.org/article/38a817e5035043189c5b339051b10be7
Autor:
Grégoire Marret, Stéphane Temam, Maud Kamal, Caroline Even, Jean-Pierre Delord, Caroline Hoffmann, Gilles Dolivet, Olivier Malard, Jérôme Fayette, Olivier Capitain, Sébastien Vergez, Lionel Geoffrois, Frédéric Rolland, Philippe Zrounba, Laurent Laccourreye, Esma Saada-Bouzid, Nicolas Aide, Valérie Bénavent, Jerzy Klijianenko, Constance Lamy, Elodie Girard, Sophie Vacher, Julien Masliah-Planchon, Leanne de Koning, Vincent Puard, Edith Borcoman, Marta Jimenez, Ivan Bièche, Jocelyn Gal, Christophe Le Tourneau
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract There is no strong and reliable predictive biomarker in head and neck squamous cell carcinoma (HNSCC) for EGFR inhibitors. We aimed to identify predictive and pharmacodynamic biomarkers of efficacy of afatinib, a pan-HER tyrosine kinase inhi
Externí odkaz:
https://doaj.org/article/71b235740be44697822692560686e4ae
Autor:
Fariba Nemati, Leanne de Koning, David Gentien, Franck Assayag, Emilie Henry, Khadija Ait Rais, Gaelle Pierron, Odette Mariani, Michèle Nijnikoff, Gabriel Champenois, André Nicolas, Didier Meseure, Sophie Gardrat, Nicolas Servant, Philippe Hupé, Maud Kamal, Christophe Le Tourneau, Sophie Piperno-Neumann, Manuel Rodrigues, Sergio Roman-Roman, Didier Decaudin, Pascale Mariani, Nathalie Cassoux
Publikováno v:
Current Oncology, Vol 30, Iss 10, Pp 9090-9103 (2023)
Uveal melanoma is the most common primary intraocular malignancy in adults. Up to 50% of UM patients develop metastatic disease, usually in the liver. When metastatic, the prognosis is poor, and few treatment options exist. Here, we investigated the
Externí odkaz:
https://doaj.org/article/42ff2385ab36479d9999c122c50772bb
Autor:
Christian Borel, Caroline Even, Christophe Le Tourneau, Jerome Fayette, Laurence Bozec, Joël Guigay, Sylvie Chabaud, Laurence Digue, Lionnel Geoffrois, Fréderic Rolland, Didier Cupissol, Anne Françoise Dillies, Sylvie Zanetta, Sophie Couchon-Thaunat, Valérie Costes-Martineau, Anne Sudaka-Bahadoran, Isabelle Jallut, Florence Garic, Audrey Lardy-Cleaud
Publikováno v:
BMJ Oncology, Vol 2, Iss 1 (2023)
Objective Salivary gland cancers (SGC) are rare cancers with currently no standard treatment for recurrent/metastatic disease. Based on checkpoint inhibitors benefit in a broad range of tumours, NIvolumab in Salivary gland CArcinoma of the Head and N
Externí odkaz:
https://doaj.org/article/052fd89043554401a71844df62d952d0
Autor:
Bao-Tram Thi Tran, Aurore Gelin, Sylvère Durand, Matthieu Texier, Amaury Daste, Clémence Toullec, Karim Benihoud, Ingrid Breuskin, Philippe Gorphe, Florence Garic, Catherine Brenner, Christophe Le Tourneau, Jérôme Fayette, Toshiro Niki, Muriel David, Pierre Busson, Caroline Even
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTExtra-cellular galectins 1, 3 and 9 (gal-1, −3 and −9) are known to act as soluble immunosuppressive agents in various malignancies. Previous publications have suggested that their expression is dependent on the metabolic status of produc
Externí odkaz:
https://doaj.org/article/719766cfc1884b85a06769ebea03df1c
Autor:
Valentine Grumberg, Christos Chouaïd, Anne-Françoise Gaudin, Christophe Le Tourneau, Aurélien Marabelle, Isabelle Bongiovanni-Delarozière, François-Emery Cotté, Isabelle Borget
Publikováno v:
JCO Global Oncology, Vol , Iss 9 (2023)
PURPOSEIn 2020, the French National Authority for Health (Haute Autorité de Santé) published a methodologic guide called organizational impact (OI) cartography to define and structure assessment of the OI of health technologies. As immunotherapies
Externí odkaz:
https://doaj.org/article/59e0d1489d4f43e8bdb2660661d4727d
Autor:
Juliette Mainguené, Sophie Vacher, Maud Kamal, Abderaouf Hamza, Julien Masliah‐Planchon, Sylvain Baulande, Sabrina Ibadioune, Edith Borcoman, Wulfran Cacheux, Valentin Calugaru, Laura Courtois, Carole Crozes, Marc Deloger, Elodie Girard, Jean‐Pierre Delord, Antoine Dubray‐Vautrin, Linda Larbi Chérif, Celia Dupain, Emmanuelle Jeannot, Jerzy Klijanienko, Sonia Lameiras, Charlotte Lecerf, Anouchka Modesto, Alain Nicolas, Roman Rouzier, Esma Saada‐Bouzid, Pierre Saintigny, Anne Sudaka, Nicolas Servant, Christophe Le Tourneau, Ivan Bièche
Publikováno v:
Molecular Oncology, Vol 16, Iss 16, Pp 3001-3016 (2022)
A prevalence of around 26% of human papillomavirus (HPV) in head and neck squamous cell carcinoma (HNSCC) has been previously reported. HPV induced oncogenesis mainly involving E6 and E7 viral oncoproteins. In some cases, HPV viral DNA has been detec
Externí odkaz:
https://doaj.org/article/d06dd36b1af84cd3acb67648ff2cbc2c
Autor:
Christophe Le Tourneau, Massimo Ghiani, Maria Chiara Cau, Roberta Depenni, Graziana Ronzino, Pierluigi Bonomo, Vincenzo Montesarchio, Luigi Leo, Jeltje Schulten, Satu Salmio, Diethelm Messinger, Andrea Sbrana, Edith Borcoman, Maria Grazia Ghi
Publikováno v:
Cancer Reports, Vol 6, Iss 5, Pp n/a-n/a (2023)
Abstract Background ENCORE, an observational, prospective, open‐label study, investigated real‐world treatment practices and outcomes with cetuximab plus platinum‐based therapy (PBT) in first‐line (1L) recurrent and/or metastatic squamous cel
Externí odkaz:
https://doaj.org/article/2aac3541984b4cb79407e47c1b6ba1ae