Výsledky vyhledávání - "Christophe Lanneau"

Abstract 3269: Ablation of Cbl-b gene function leads to increased activation and resistance to immunosuppression in human primary T lymphocytes

Autor: Céline Nicolazzi, Christophe Lanneau, Cécile Orsini, Sophie Boisrobert-Blais, Georges Kalouche, Eric Parmantier, Clara Soulard

Publikováno v: Cancer Research. 80:3269-3269

Purpose: The role of Cbl-b as an essential modulator of T cell activation has been widely documented, particularly in mouse studies. To substantiate the effects of Cbl-b ablation in human T cells, gene editing conditions were optimized, and gene KO e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9425c69f9b5006d6e8a2944234f4b64
https://doi.org/10.1158/1538-7445.am2020-3269

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Functional Studies of Sodium Channels: From Target to Compound Identification

Autor: Thomas Licher, Daniel Bertrand, Jean-Marie Chambard, Isabel A. Lefevre, Bruno Biton, Michel Partiseti, Christophe Lanneau

Publikováno v: Current Protocols in Pharmacology

Over the last six decades, voltage-gated sodium (Nav ) channels have attracted a great deal of scientific and pharmaceutical interest, driving fundamental advances in both biology and technology. The structure and physiological function of these chan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::915596759b76970215116367c9696128
https://doi.org/10.1002/cpph.14

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Abstract 1272: Whole genome Crispr screening to identify potential SERD molecule resistance mechanisms

Autor: Christophe Marcireau, Karine Berthelot, Alice Williart, Hamida Fournet, Delphine Debono, Gilbert Thill, Helene Erasimus, Dorine Chassin, Christophe Lanneau, Veeanagouda Yaligara, Cecile Orsini, Michel Didier, Vincent Mikol, Monsif Bouaboula, Laurent Debussche

Publikováno v: Cancer Research. 79:1272-1272

Metastatic breast cancer results in substantial morbidity and mortality for women afflicted with this disease. Approximately 80% of breast cancers express the estrogen receptor. The cancer cell survival and proliferation is driven by the activation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::32aee58da4359ab28845d0dfb8d62b50
https://doi.org/10.1158/1538-7445.am2019-1272

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Characterization of SSR103800, a selective inhibitor of the glycine transporter-1 in models predictive of therapeutic activity in schizophrenia☆

Publikováno v: Pharmacology Biochemistry and Behavior. 91:47-58

On native human, rat and mouse glycine transporter-1(GlyT1), SSR130800 behaves as a selective inhibitor with IC50 values of 1.9, 5.3 and 6.8 nM, respectively. It reversibly blocked glycine uptake in mouse brain cortical homogenates, increased extrace

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6687966391f5ff03ce02d4870bfc9701
https://doi.org/10.1016/j.pbb.2008.06.009

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Capsazepine Protects against Neuronal Injury Caused by Oxygen Glucose Deprivation by InhibitingIh

Autor: Danniel P. Gitterman, Jenny C. Roberts, John B. Davis, Alison M. Ray, Ceri D. Benham, Mark H Harries, Christopher H. Davies, Catherine H. Gill, Christophe Lanneau

Publikováno v: The Journal of Neuroscience. 23:10146-10153

Cell death mechanisms frequently involve the influx of extracellular calcium through voltage- and ligand-gated ion channels, e.g., the NMDA receptor (Greene, 1999). The vanilloid receptor (VR1) is present in regions of the brain (Mezey et al., 2000)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77ab18d935185384f9c9e686d6788908
https://doi.org/10.1523/jneurosci.23-31-10146.2003

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Involvement of the Sst1 Somatostatin Receptor Subtype in the Intrahypothalamic Neuronal Network Regulating Growth Hormone Secretion: Anin Vitroandin VivoAntisense Study1

Autor: Zsolt Csaba, Christophe Lanneau, Jacques Epelbaum, Lone Helboe, Robert Gardette, Daniel Hoyer, Philippe Zizzari, Gloria Shaffer Tannenbaum, Elisabeth Pellegrini, Pascal Dournaud, Marie Thérèse Bluet-Pajot

Publikováno v: Endocrinology. 141:967-979

Five somatostatin (SRIH) receptors (sst1–5) have been cloned. Recent anatomical evidence suggests that sst1 and sst2 may be involved in the central regulation of GH secretion. Given the lack of specific receptor antagonists, we used selective antis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::92869115660003ce59125ecc2810641b
https://doi.org/10.1210/endo.141.3.7349

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Cortistatin affects glutamate sensitivity in mouse hypothalamic neurons through activation of somatostatin receptor subtype

Autor: Robert Gardette, P Dournand, Christophe Lanneau, A Vassilaki, Jacques Epelbaum, L de Lecea

Publikováno v: Neuroscience. 88:359-364

Cortistatin is a 14-residue putative neuropeptide with strong structural similarity to somatostatin. Even if it shares several biological properties with somatostatin, the effects of cortistatin on cortical electrical activity and sleep are opposite

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f0421f979f21d1bbe8f1ef70a22f42e
https://doi.org/10.1016/s0306-4522(98)00413-8

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