Zobrazeno 1 - 10 of 148 pro vyhledávání: '"Christophe L M J Verlinde"'
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Akademický článek
Structures of Trypanosoma brucei methionyl-tRNA synthetase with urea-based inhibitors provide guidance for drug design against sleeping sickness.
Autor: Cho Yeow Koh, Jessica E Kim, Allan B Wetzel, Will J de van der Schueren, Sayaka Shibata, Ranae M Ranade, Jiyun Liu, Zhongsheng Zhang, J Robert Gillespie, Frederick S Buckner, Christophe L M J Verlinde, Erkang Fan, Wim G J Hol
Publikováno v: PLoS Neglected Tropical Diseases, Vol 8, Iss 4, p e2775 (2014)
Methionyl-tRNA synthetase of Trypanosoma brucei (TbMetRS) is an important target in the development of new antitrypanosomal drugs. The enzyme is essential, highly flexible and displaying a large degree of changes in protein domains and binding pocket
Externí odkaz: https://doaj.org/article/d5d82033472f498782042305c840c109
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2
Spontaneous Selection of Cryptosporidium Drug Resistance in a Calf Model of Infection
Autor: Erkang Fan, Jose E. Teixeira, Adam Sateriale, Christopher D. Huston, John R. Gillespie, Peter Jonathon Miller, Muhammad M. Hasan, Erin E. Stebbins, Frederick S. Buckner, Zhongsheng Zhang, Robert K. M. Choy, Christophe L. M. J. Verlinde, Ranae M. Ranade, Eugenio L. de Hostos, Aisha Mushtaq, Damon M. Osbourn, David W. Griggs
Publikováno v: Antimicrob Agents Chemother
The intestinal protozoan Cryptosporidium is a leading cause of diarrheal disease and mortality in young children. There is currently no fully effective treatment for cryptosporidiosis, which has stimulated interest in anticryptosporidial development
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec9d4e0b2a43263d5bede9707a02798d
https://doi.org/10.1128/aac.00023-21
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5
The calcium-dependent protein kinase 1 from Toxoplasma gondii as target for structure-based drug design
Autor: Ehmke Pohl, Emily M Cardew, Christophe L. M. J. Verlinde
Publikováno v: Parasitology
Parasitology, 2018, Vol.145(2), pp.210-218 [Peer Reviewed Journal]
SummaryThe apicomplexan protozoan parasites include the causative agents of animal and human diseases ranging from malaria (Plasmodium spp.) to toxoplasmosis (Toxoplasma gondii). The complex life cycle of T. gondii is regulated by a unique family of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93c04018a2b25590e5eba9f513dee206
http://europepmc.org/articles/PMC5964469
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6
Optimization of Methionyl tRNA-Synthetase Inhibitors for Treatment of Cryptosporidium Infection
Autor: Samuel L.M. Arnold, Erkang Fan, Wim G. J. Hol, Frederick S. Buckner, Christophe L. M. J. Verlinde, Matthew A. Hulverson, J. Robert Gillespie, Zhongsheng Zhang, Yuichiro Akao, Christopher D. Huston, Wesley C. Van Voorhis, Wenlin Huang, Rajiv S. Jumani, Robert K. M. Choy, Sayaka Shibata, Ryan Choi, Ranae M. Ranade, Atsuko Ochida
Publikováno v: Antimicrobial Agents and Chemotherapy. 63
Cryptosporidiosis is one of the leading causes of moderate to severe diarrhea in children in low-resource settings. The therapeutic options for cryptosporidiosis are limited to one drug, nitazoxanide, which unfortunately has poor activity in the most
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b1f8821323bdd5521edd9f388e66206b
https://doi.org/10.1128/aac.02061-18
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7
5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors
Autor: Ranae M. Ranade, Zhongsheng Zhang, Michael H. Gelb, Cho Yeow Koh, Wenlin Huang, Sayaka Shibata, Christophe L. M. J. Verlinde, Frederick S. Buckner, J. Robert Gillespie, Nagendar Pendem, Matthew A. Hulverson, Wim G. J. Hol, Jasmine Nguyen, Erkang Fan
Publikováno v: ACS Infectious Diseases
Fluorination is a well-known strategy for improving the bioavailability of drug molecules. However, its impact on efficacy is not easily predicted. On the basis of inhibitor-bound protein crystal structures, we found a beneficial fluorination spot fo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4db5f20582e2bbb9f30329e81c668393
https://doi.org/10.1021/acsinfecdis.6b00036
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8
Optimization of Methionyl tRNA-Synthetase Inhibitors for Treatment of
Autor: Frederick S, Buckner, Ranae M, Ranade, J Robert, Gillespie, Sayaka, Shibata, Matthew A, Hulverson, Zhongsheng, Zhang, Wenlin, Huang, Ryan, Choi, Christophe L M J, Verlinde, Wim G J, Hol, Atsuko, Ochida, Yuichiro, Akao, Robert K M, Choy, Wesley C, Van Voorhis, Sam L M, Arnold, Rajiv S, Jumani, Christopher D, Huston, Erkang, Fan
Publikováno v: Antimicrobial agents and chemotherapy. 63(4)
Cryptosporidiosis is one of the leading causes of moderate to severe diarrhea in children in low-resource settings. The therapeutic options for cryptosporidiosis are limited to one drug, nitazoxanide, which unfortunately has poor activity in the most
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e07f5621d8529bde8d2d67099090a4ab
https://pubmed.ncbi.nlm.nih.gov/30745384
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9
The crystal structure of the drug target Mycobacterium tuberculosis methionyl-tRNA synthetase in complex with a catalytic intermediate
Autor: Ximena Barros-Álvarez, Wim G. J. Hol, Christophe L. M. J. Verlinde, Stewart Turley, Frederick S. Buckner, Erkang Fan, Ranae M. Ranade, Nicole A. Duster, J. Robert Gillespie
Publikováno v: Acta crystallographica. Section F, Structural biology communications. 74(Pt 4)
Mycobacterium tuberculosisis a pathogenic bacterial infectious agent that is responsible for approximately 1.5 million human deaths annually. Current treatment requires the long-term administration of multiple medicines with substantial side effects.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad516900a218118c0837986e79de63ec
https://pubmed.ncbi.nlm.nih.gov/29633973
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10
A binding hotspot inTrypanosoma cruzihistidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens
Autor: Erkang Fan, Christophe L. M. J. Verlinde, J. Robert Gillespie, Wim G. J. Hol, Cho Yeow Koh, Frederick S. Buckner, Ranae M. Ranade, Latha Kallur Siddaramaiah, Zhongsheng Zhang, Tengyue Jian, Jasmine Nguyen
Publikováno v: Acta Crystallographica Section D Biological Crystallography. 71:1684-1698
American trypanosomiasis, commonly known as Chagas disease, is a neglected tropical disease caused by the protozoan parasiteTrypanosoma cruzi. The chronic form of the infection often causes debilitating morbidity and mortality. However, the current t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cd9fec39276ef1eb17f56fc45b2d413
https://doi.org/10.1107/s1399004715007683
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