Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Christophe Kunz"'
Autor:
Christophe Kunz, Frauke Focke, Yusuke Saito, David Schuermann, Teresa Lettieri, Jim Selfridge, Primo Schär
Publikováno v:
PLoS Biology, Vol 7, Iss 4, p e91 (2009)
5-Fluorouracil (5-FU), a chemotherapeutic drug commonly used in cancer treatment, imbalances nucleotide pools, thereby favoring misincorporation of uracil and 5-FU into genomic DNA. The processing of these bases by DNA repair activities was proposed
Externí odkaz:
https://doaj.org/article/4165cec158c9407b8bacefe22d778183
Autor:
Tabea Rambach, Patricia Gleim, Sekina Mandelartz, Carolin Heizmann, Christophe Kunze, Philipp Kellmeyer
Publikováno v:
JMIR Research Protocols, Vol 13, p e58185 (2024)
BackgroundIn the last few years, there has been an increasing interest in the development of artificial intelligence (AI)–based clinical decision support systems (CDSS). However, there are barriers to the successful implementation of such systems i
Externí odkaz:
https://doaj.org/article/f35bc117608e41368ed40158382984ef
Autor:
Christian Plotzky, Barbara Loessl, Barbara Kuhnert, Nina Friedrich, Christiane Kugler, Peter König, Christophe Kunze
Publikováno v:
BMC Nursing, Vol 22, Iss 1, Pp 1-18 (2023)
Abstract Background Clinical skills training is an essential component of nursing education. However, sometimes education does not sufficiently prepare nurses for the real world. Virtual reality (VR) is an innovative method to complement existing lea
Externí odkaz:
https://doaj.org/article/9b2f6b6a2d92477d87eca75316bbab40
Autor:
Erik van Nimwegen, Primo Schaer, Georges Martin, Foivos Gypas, Mihaela Zavolan, Christophe Kunz, Nitish Mittal, Friedel Wenzel, Shivendra Kishore
Ewing Sarcoma break point region 1 (EWSR1) is a multi-functional RNA-binding protein that is involved in many cellular processes, from gene expression to RNA processing and transport. Translocations into its locus lead to chimeric proteins with tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be14c1b37a035c49178357326f8b01a7
Autor:
Primo Schär, Christophe Kunz, Jim Selfridge, Teresa Lettieri, David Schuermann, Yusuke Saito, Angelika L. Jacobs, Roland Steinacher, Fredy Siegrist, Annika Wirz, Daniel Cortázar, Adrian Bird, Eilidh MacDougall, Josef Jiricny
Publikováno v:
Nature
Thymine DNA glycosylase (TDG) is a member of the uracil DNA glycosylase (UDG) superfamily of DNA repair enzymes. Owing to its ability to excise thymine when mispaired with guanine, it was proposed to act against the mutability of 5-methylcytosine (5-
Publikováno v:
DNA Repair. 6:489-504
When it was first isolated from extracts of HeLa cells in Josef Jiricny's laboratory, the thymine DNA glycosylase (TDG) attracted attention because of its ability to remove thymine, i.e. a normal DNA base, from G.T mispairs. This implicated a functio
Publikováno v:
Scopus-Elsevier
Europe PubMed Central
Europe PubMed Central
Rhp41 and Rhp42 of Schizosaccharomyces pombe are homologues of human XPC, which is involved in nucleotide excision repair (NER) of damaged DNA. Inactivation of rhp41 caused moderate sensitivity to ultraviolet (UV) radiation. In addition, an increase
Publikováno v:
Biochemical Journal. 372:651-660
Cmb1 (cytosine-mismatch binding 1) is a high-mobility group (HMG) protein of Schizosaccharomyces pombe, which consists of 223 amino acids and has a single HMG domain at the C-terminal end. We have created several mutant and deletion forms of the Cmb1
Publikováno v:
Journal of Cellular Physiology. 191:28-41
Unpaired and mispaired bases in DNA can arise by replication errors, spontaneous or induced base modifications, and during recombination. The major pathway for correction of mismatches arising during replication is the MutHLS pathway of Escherichia c
Autor:
Oliver Fleck, Christophe Kunz
Publikováno v:
Journal of Molecular Biology. 313:241-253
Repair of mismatched DNA occurs mainly by the long-patch mismatch repair (MMR) pathway, requiring Msh2 and Pms1. In Schizosaccharomyces pombe mismatches can be repaired by a short-patch repair system, containing nucleotide excision repair (NER) facto