Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Christophe Hardouin"'
Autor:
Sylvain Lemaitre, Christophe Hardouin
Publikováno v:
Organic Process Research & Development. 24:867-871
Methanolic hydrochloride is a commonly used reagent on the lab scale and on larger scales as well. It is commercially available or can be prepared by bubbling gaseous hydrogen chloride in methanol....
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e94d25be4a886eccdbcb42e52e77af49
https://doi.org/10.1021/acs.oprd.0c00034
https://doi.org/10.1021/acs.oprd.0c00034
Autor:
Chloé Copin, François Barière, Anthony Craquelin, Solenn Janvier, Sylvain Lemaitre, Sébastien Samson, Sandrine Baillard, Olivier Russo, Christophe Hardouin, Stéphane Le Roux
Publikováno v:
Organic Process Research & Development. 24:652-669
Our efforts toward the process development of drug candidate 1 are described in a series of two papers. This manuscript focuses on the synthesis of kilogram quantities of acid precursor 2 to provid...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed4125e9a1becd66e9e190e3d5397143
https://doi.org/10.1021/acs.oprd.9b00364
https://doi.org/10.1021/acs.oprd.9b00364
Autor:
Stéphane Le Roux, Sandrine Baillard, Olivier Russo, Christophe Hardouin, François Barière, Anthony Craquelin, Mathieu Grandjean, Christine Penloup, Solenn Janvier
Publikováno v:
Organic Process Research & Development. 24:670-685
This paper describes the synthesis of kilogram quantities of the sulfonamide moiety 3 involved in a coupling reaction with acid moiety 2 to provide batches of drug candidate 1 for preclinical studi...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9dd10adf791c4b850e0120fa8859053e
https://doi.org/10.1021/acs.oprd.9b00367
https://doi.org/10.1021/acs.oprd.9b00367
Autor:
Jean-François Giffard, Christophe Hardouin, Peng Zhang, Frédéric Pin, Solenn Janvier, Julien Picard, Yvon Hervouet, Nathalie Pinault, Bruno Schiavi, Xueyan Zhu, Weiwei Zhao, Julie Hublet, Christine Penloup
Publikováno v:
Organic Process Research & Development. 23:1932-1947
This work describes the process development and manufacture of an ampakine-type active pharmaceutical ingredient in clinical trials. A regioselective CDI-mediated amidation process was optimized fo...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66c6aa919591449147075b5716c26a95
https://doi.org/10.1021/acs.oprd.9b00241
https://doi.org/10.1021/acs.oprd.9b00241
Publikováno v:
ACS Symposium Series ISBN: 9780841298644
ACS Symposium Series
ACS Symposium Series
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb07fb59eea17cb8c59129a3cc6fc33f
https://doi.org/10.1021/bk-2020-1369.ch006
https://doi.org/10.1021/bk-2020-1369.ch006
Autor:
François Barière, Yvon Hervouet, Christophe Hardouin, Patrick Mouchet, Aurélie Poixblanc, Thierry Dubuffet, Rodolphe Tamion
Publikováno v:
Organic Process Research & Development. 22:1419-1425
A new manufacturing process for N-[[1-(methylamino)cyclopropyl]methyl]pyridine-3-amine hemigalactarate (1) has been developed. Herein we wish to report the development and optimization of the route using alternative reaction conditions for a reductio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c893d08b5609c877216ffb93eaab9a5e
https://doi.org/10.1021/acs.oprd.8b00220
https://doi.org/10.1021/acs.oprd.8b00220
Autor:
Aurélie Viger, Sylvain Laclef, Christine Penloup, Christophe Hardouin, Vincent Levacher, Catherine Taillier, Jean-François Brière
Publikováno v:
RSC Advances
RSC Advances, Royal Society of Chemistry, 2014, 4 (75), pp.39817-39821. ⟨10.1039/c4ra07821g⟩
RSC Advances, Royal Society of Chemistry, 2014, 4 (75), pp.39817-39821. ⟨10.1039/c4ra07821g⟩
The asymmetric synthesis of a 1,3-diamine building block for the elaboration of Bcl-2 and Bcl-xL protein inhibitors is described through two key steps: (1) a highly diastereoselective aza-Reformatsky reaction, and (2) a chemoselective amination under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e4b44fda18c098077a0c43d36a5545f
https://doi.org/10.1039/c4ra07821g
https://doi.org/10.1039/c4ra07821g
Publikováno v:
Tetrahedron. 69:9322-9328
The asymmetric hydrogenation of a series of quinolines substituted by a variety of functionalized groups linked to the C2 carbon atom is providing access to optically enriched 2-functionalized 1,2,3,4-tetrahydroquinolines in the presence of in situ g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4eef0b859715d599e65ecb634ad984a3
https://doi.org/10.1016/j.tet.2013.07.090
https://doi.org/10.1016/j.tet.2013.07.090
Autor:
Isabelle Suisse, Catherine Méliet, Christophe Hardouin, Anna M. Maj, Francine Agbossou-Niedercorn
Publikováno v:
Tetrahedron Letters. 53:4747-4750
The asymmetric hydrogenation of a new series of 2-functionalized quinolines has been developed in the presence of in situ generated catalysts obtained from [Ir(cod)Cl]2/(R)-bisphosphine/I2 combinations. The enantioselectivity levels were as high as 8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40ed564d05b132ff00311b6bf69646ce
https://doi.org/10.1016/j.tetlet.2012.06.114
https://doi.org/10.1016/j.tetlet.2012.06.114
Publikováno v:
Nature Biotechnology. 21:687-691
To realize the promise of genomics-based therapeutics, new methods are needed to accelerate the discovery of small molecules that selectively modulate protein activity. Toward this end, advances in combinatorial synthesis have provided unprecedented
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8ea4e59f4fa8c4c6922363fe36e3472
https://doi.org/10.1038/nbt826
https://doi.org/10.1038/nbt826