Výsledky vyhledávání - "Christophe Guionaud"

Proteins mediating the Neospora caninum-host cell interaction as targets for vaccination

Autor: Michelle Schorer, Joachim Mueller, Ferial Alaeddine, Andrew Hemphill, Thierry Monney, Norbert Mueller, Karim Debache, Christophe Guionaud

Publikováno v: Frontiers in Bioscience. :23-36

Neospora caninum is an apicomplexan parasite that is capable of infecting, a wide range of tissues. The fact that Neospora represents an important abortion-causing parasite in cattle has transformed neosporosis research from an earlier, rather esoter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dca5e817d4431d0d8f56deb3a8a4747
https://doi.org/10.2741/e593

Zobrazit plný text záznamu

Molecular cloning and characterization of NcROP2Fam-1, a member of the ROP2 family of rhoptry proteins in Neospora caninum that is targeted by antibodies neutralizing host cell invasion in vitro

Autor: Karim Debache, Andrew Hemphill, Ferial Alaeddine, Christophe Guionaud

Publikováno v: Parasitology
Alaeddine, Ferial; Hemphill, Andrew; Debache, Karim; Guionaud, Christophe (2013). Molecular cloning and characterization of NcROP2Fam-1, a member of the ROP2 family of rhoptry proteins in Neospora caninum that is targeted by antibodies neutralizing host cell invasion in vitro. Parasitology, 140(8), pp. 1033-1050. Cambridge University Press 10.1017/S0031182013000383

SUMMARYRecent publications demonstrated that a fragment of aNeospora caninumROP2 family member antigen represents a promising vaccine candidate. We here report on the cloning of the cDNA encoding this protein,N. caninumROP2 family member 1 (NcROP2Fam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1f91673b9313db6f97dbe70bd4f8a3f

Zobrazit plný text záznamu

Experimental treatment of Neospora caninum-infected mice with the arylimidamide DB750 and the thiazolide nitazoxanide

Autor: Karim Debache, Christian Kropf, Chad E. Stephens, Christophe Guionaud, David W. Boykin, Andrew Hemphill

Publikováno v: Experimental parasitology

The cationic arylimidamide DB750 and the thiazolide nitazoxanide had been shown earlier to be effective against Neospora caninum tachyzoites in vitro with an IC 50 of 160 nM and 4.23 μM, respectively. In this study, we have investigated the effects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36e253a26054ffdd758107870436b8c6
https://doi.org/10.1016/j.exppara.2011.07.010

Zobrazit plný text záznamu

Intraperitoneal and intra-nasal vaccination of mice with three distinct recombinantNeospora caninumantigens results in differential effects with regard to protection against experimental challenge withNeospora caninumtachyzoites

Autor: Karim Debache, Ferial Alaeddine, Andrew Hemphill, Christophe Guionaud

Publikováno v: Debache, K.; Guionaud, C.; Alaeddine, F.; Hemphill, A. (2010). Intraperitoneal and intra-nasal vaccination of mice with three distinct recombinant Neospora caninum antigens results in differential effects with regard to protection against experimental challenge with Neospora caninum tachyzoites. Parasitology, 137(2), pp. 229-40. London: Cambridge University Press 10.1017/S0031182009991259

SUMMARYRecombinant NcPDI(recNcPDI), NcROP2(recNcROP2), and NcMAG1(recNcMAG1) were expressed inEscherichia coliand purified, and evaluated as potential vaccine candidates by employing the C57Bl/6 mouse cerebral infection model. Intraperitoneal applica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67d866d6c067f46875da349f722f2377
https://doi.org/10.1017/s0031182009991259

Zobrazit plný text záznamu

Vaccination with recombinant NcROP2 combined with recombinant NcMIC1 and NcMIC3 reduces cerebral infection and vertical transmission in mice experimentally infected with Neospora caninum tachyzoites

Autor: Karim Debache, Stephen L. Leib, Maria Strohbusch, Denis Grandgirard, Joachim Müller, Andrew Hemphill, Ferial Alaeddine, Christophe Guionaud, Thierry Monney

Publikováno v: International Journal for Parasitology. 39:1373-1384

We investigated the protective potential of recombinant his-tagged antigens recNcMIC1, recNcMIC3 and recNcROP2, applied either as single vaccines or as vaccine combinations, in BALB/c mouse models for cerebral and fetal infection. Subsequently, mice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a527b857c3b389f949a4a76ba45c999
https://doi.org/10.1016/j.ijpara.2009.04.006

Zobrazit plný text záznamu

Neospora caninum protein disulfide isomerase is involved in tachyzoite-host cell interaction

Autor: Meike Mevissen, Arunasalam Naguleswaran, Ferial Alaeddine, Sabrina Sonda, Andrew Hemphill, Nathalie Vonlaufen, Christophe Guionaud, Paul Jenoe

Publikováno v: International Journal for Parasitology. 35:1459-1472

We have previously shown that treatment of Neospora caninum tachyzoites with the aspartyl protease inhibitor pepstatin A reduces host cell invasion [Naguleswaran, A., Muller, N., Hemphill, A., 2003. Neospora caninum and Toxoplasma gondii: a novel adh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816aa92e25e19ed371ac09673fcb6ec0
https://doi.org/10.1016/j.ijpara.2005.06.006

Zobrazit plný text záznamu

Molecular Cloning and Functional Characterization of a Unique Mammalian Cardiac Nav Channel Isoform with Low Sensitivity to the Synthetic Inactivation Inhibitor (−)-(S)-6-Amino-α-[(4-diphenylmethyl-1-piperazinyl)-methyl]-9H-purine-9-ethanol (SDZ 211-939)

Autor: Nikolaus G. Greeff, Christophe Guionaud, Günter Scholtysik, Meike Mevissen, Helena Denac, Frank J.P. Kühn, Cornelia Kühn

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 303:89-98

Cardiac voltage-dependent sodium channels (Na(v)) are drug targets for synthetic inactivation inhibitors typified by (+/-)-4- [3-(4-diphenylmethyl-1-piperazinyl)-2-hydroxy propoxy]-1H-indole-2-carbonitrile (DPI 201-106), of which the molecular mode o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc3e1992b7cb7c7d770f6810d5b4b5a5
https://doi.org/10.1124/jpet.303.1.89

Zobrazit plný text záznamu

Expression and function of 5-hydroxytryptamine 4 receptors in smooth muscle preparations from the duodenum, ileum, and pelvic flexure of horses without gastrointestinal tract disease

Autor: Andrea S. Prause, Meike Mevissen, Christopher J. Portier, Michael Hubert Stoffel, Christophe Guionaud

Publikováno v: American journal of veterinary research. 71(12)

Objective—To evaluate the expression of the 5-hydroxytryptamine 4 (5-HT4) receptor subtype and investigate the modulating function of those receptors on contractility in intestinal tissues obtained from horses without gastrointestinal tract disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32350c9f049992ff7c5db33fc916bd2a
https://pubmed.ncbi.nlm.nih.gov/21117994

Zobrazit plný text záznamu

Molecular characterization of Neospora caninum MAG1, a dense granule protein secreted into the parasitophorous vacuole, and associated with the cyst wall and the cyst matrix

Autor: Christophe Guionaud, Meike Mevissen, Andrew Hemphill, Ferial Alaeddine

Publikováno v: Guionaud, C.; Hemphill, A.; Mevissen, M.; Alaeddine, F. (2010). Molecular characterization of Neospora caninum MAG1, a dense granule protein secreted into the parasitophorous vacuole, and associated with the cyst wall and the cyst matrix. Parasitology, 137(11), pp. 1605-19. London: Cambridge University Press 10.1017/S0031182010000442

SUMMARYInNeospora caninumandToxoplasma gondii, the parasitophorous vacuole (PV) is synthesized at the time of infection. During tachyzoite-to-bradyzoite stage conversion, the PV is later transformed into a tissue cyst that allows parasites to survive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eca2461cee57c9b210e8c272696c755
https://pubmed.ncbi.nlm.nih.gov/20444303

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání