Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Christophe Grundschober"'
Autor:
Chloe Hegoburu, Yan Tang, Ruifang Niu, Supriya Ghosh, Rodrigo Triana Del Rio, Isabel de Araujo Salgado, Marios Abatis, David Alexandre Mota Caseiro, Erwin H. van den Burg, Christophe Grundschober, Ron Stoop
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The presence of a companion can reduce fear, but the neural mechanisms underlying this social buffering of fear are incompletely known. We studied social buffering of fear in male and female, and its encoding in the amygdala of male, auditor
Externí odkaz:
https://doaj.org/article/b58bf69782eb4b4db4ecba5e07e13753
Autor:
Philipp Janz, Frederic Knoflach, Konrad Bleicher, Sara Belli, Barbara Biemans, Patrick Schnider, Martin Ebeling, Christophe Grundschober, Madhurima Benekareddy
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
IntroductionSocial behavioral changes are a hallmark of several neurodevelopmental and neuropsychiatric conditions, nevertheless the underlying neural substrates of such dysfunction remain poorly understood. Building evidence points to the prefrontal
Externí odkaz:
https://doaj.org/article/e37f651846634462bb07b6af09bb1c64
Autor:
Philipp Janz, Frederic Knoflach, Konrad Bleicher, Sara Belli, Barbara Biemans, Patrick Schnider, Martin Ebeling, Christophe Grundschober, Madhurima Benekareddy
Social behavioral changes are a hallmark of several neurodevelopmental and neuropsychiatric conditions, nevertheless the underlying neural substrates of such dysfunction remain poorly understood. Building evidence points to the prefrontal cortex (PFC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5517d0992a4a1b80793242e33bfdd738
https://doi.org/10.1101/2022.11.08.515590
https://doi.org/10.1101/2022.11.08.515590
Autor:
Schnider Patrick, Erwin Goetschi, Neil Parrott, Hasane Ratni, Markus von Kienlin, Basil Künnecke, Celine Risterucci, Cosimo Dolente, Mark Rogers-Evans, Roland Jakob-Roetne, Christophe Grundschober, Andreas Bruns, Caterina Bissantz, Emmanuel Pinard, Wolfgang Muster, Thomas Mueggler
Publikováno v:
Journal of medicinal chemistry. 63(4)
We recently reported the discovery of a potent, selective, and brain-penetrant V1a receptor antagonist, which was not suitable for full development. Nevertheless, this compound was found to improve surrogates of social behavior in adults with autism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b81a9362ac94dbb48af9cbb342a3c3
https://pubmed.ncbi.nlm.nih.gov/31951127
https://pubmed.ncbi.nlm.nih.gov/31951127
Autor:
Andy Stucki, Edward W. Tate, Rhiannon Beard, Gabrielle Py, Muriel Schmitt, Antony D. Gee, Christophe Grundschober
Publikováno v:
Beard, R, Stucki, A, Schmitt, M, Py, G, Grundschober, C, Gee, A & Tate, E 2018, ' Building bridges for highly selective, potent and stable oxytocin and vasopressin analogs ', Bioorganic and Medicinal Chemistry . https://doi.org/10.1016/j.bmc.2018.03.019
Oxytocin (OT) is an exciting potential therapeutic agent, but it is highly sensitive to modification and suffers extensive degradation at elevated temperature and in vivo. Here we report studies towards OT analogs with favorable selectivity, affinity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b540c7ee40b7ca53feda3d015e277de6
https://doi.org/10.1016/j.bmc.2018.03.019
https://doi.org/10.1016/j.bmc.2018.03.019
Autor:
Lauren Boak, Omar Khwaja, Daniel Umbricht, Christophe Grundschober, James T. McCracken, Eric Hollander, Heidemarie Kletzl, Lisa Squassante, Marta del Valle Rubido, Frederick Shic, Jana Noeldeke, Lawrence Scahill, Paulo Fontoura
Publikováno v:
Neuropsychopharmacology
The core symptoms of autism spectrum disorder (ASD) include impaired social communication, repetitive behaviors, and restricted interests. No effective pharmacotherapy for these core deficits exists. Within the domain of social communication, the vas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bb3089c290e8c76df240cee68616bff
https://doi.org/10.1038/npp.2016.232
https://doi.org/10.1038/npp.2016.232
Publikováno v:
Chemical Communications (Cambridge, England)
Probing the mechanism of intranasal oxytocin brain uptake through generation and validation of a novel peptide PET tracer.
A novel Al18F labelled peptide tracer for PET imaging of oxytocin receptor has been accessed through a high radiochemical
A novel Al18F labelled peptide tracer for PET imaging of oxytocin receptor has been accessed through a high radiochemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::940d196c4c9c46747349a8b8431e39b2
https://pubmed.ncbi.nlm.nih.gov/29974895
https://pubmed.ncbi.nlm.nih.gov/29974895
Publikováno v:
Beard, R, Singh, N, Grundschober, C, Gee, A D & Tate, E W 2018, ' High-yielding 18F radiosynthesis of a novel oxytocin receptor tracer, a probe for nose-to-brain oxytocin uptake in vivo ', CHEMICAL COMMUNICATIONS-ROYAL SOCIETY OF CHEMISTRY, vol. 54, no. 58, pp. 8120-8123 . https://doi.org/10.1039/C8CC01400K
A novel Al18F labelled peptide tracer for PET imaging of oxytocin receptor has been accessed through a high radiochemical yield approach. This tracer showed comparable affinity and higher selectivity and stability compared to oxytocin, and was used t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79cf1a0e2d1f9fcf9cd076cf0619ea4b
https://kclpure.kcl.ac.uk/en/publications/5d02860c-0054-4963-be10-1448b4640e19
https://kclpure.kcl.ac.uk/en/publications/5d02860c-0054-4963-be10-1448b4640e19
Autor:
Christophe Grundschober, Basil Kuennecke, Philipp Janz, Madhurima Benekareddy, Frederic Knofach
Publikováno v:
Biological Psychiatry. 85:S317
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::579d022cf57e61498e0f0b9bea4acc45
https://doi.org/10.1016/j.biopsych.2019.03.805
https://doi.org/10.1016/j.biopsych.2019.03.805
Autor:
Eric Prinssen, Christophe Grundschober, Laurent B. Nicolas, Jean-Luc Moreau, Joseph G. Wettstein, Cristina Lopez-Lopez, Andreas Bruns, Steffen Klein, Melanie S. Keßler, Markus von Kienlin, Celine Risterucci
Publikováno v:
European Neuropsychopharmacology. 22:441-451
Functional magnetic resonance imaging (fMRI) has become an important method in clinical psychiatry research whereas there are still only few comparable preclinical investigations. Herein, we report that fMRI in rats can provide key information regard
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3de0cac1d79ca6643817cb0d3de0d503
https://doi.org/10.1016/j.euroneuro.2011.11.001
https://doi.org/10.1016/j.euroneuro.2011.11.001