Toll-like receptor-9 stimulated plasmacytoid dendritic cell precursors suppress autoimmune neuroinflammation in a murine model of multiple sclerosis

Autor: Hélène Letscher, Viviane A. Agbogan, Sarantis Korniotis, Pauline Gastineau, Emmanuel Tejerina, Christophe Gras, Jérôme Mégret, Alison Moe, William R. Drobyski, Flora Zavala

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)

Abstract Early innate education of hematopoietic progenitors within the bone marrow (BM) stably primes them for either trained immunity or instead immunoregulatory functions. We herein demonstrate that in vivo or in vitro activation within the BM via

Externí odkaz: https://doaj.org/article/c4fd5c13ee9141009cc44b6049bbacf9

Treatment of ongoing autoimmune encephalomyelitis with activated B-cell progenitors maturing into regulatory B cells

Autor: Sarantis Korniotis, Christophe Gras, Hélène Letscher, Ruddy Montandon, Jérôme Mégret, Stefanie Siegert, Sophie Ezine, Padraic G. Fallon, Sanjiv A. Luther, Simon Fillatreau, Flora Zavala

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)

Evidence of how functional Bregs develop in vivo has been lacking. Here the authors show that proB cells exposed in vivoto CpG differentiate into distinct Breg subsets that inhibit autoimmunity by arresting T cells in the lymph nodes via CCL19 and by

Externí odkaz: https://doaj.org/article/b7d9504d2aed4006b464e2e920a9a15c

Treatment of ongoing autoimmune encephalomyelitis with activated B-cell progenitors maturing into regulatory B cells

Autor: Stefanie Siegert, Sarantis Korniotis, Flora Zavala, Sophie Ezine, Christophe Gras, Ruddy Montandon, Sanjiv A. Luther, Jérôme Mégret, Padraic G. Fallon, Hélène Letscher, Simon Fillatreau

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications
Nature Communications, vol. 7, pp. 12134

The influence of signals perceived by immature B cells during their development in bone marrow on their subsequent functions as mature cells are poorly defined. Here, we show that bone marrow cells transiently stimulated in vivo or in vitro through t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd5989198804db23429b5a90408161af
https://doi.org/10.1038/ncomms12134

Free HTLV-1 induces TLR7-dependent innate immune response and TRAIL relocalization in killer plasmacytoid dendritic cells

Autor: Françoise Raynaud, Yves Lepelletier, Olivier Hermine, Réda Hadj-Slimane, Christophe Gras, Claudine Pique, Jean-Philippe Herbeuval, Lucie Barblu, Renaud Colisson

Publikováno v: Blood
Blood, American Society of Hematology, 2010, 115 (11), pp.2177-2185. ⟨10.1182/blood-2009-06-224741⟩
Blood, American Society of Hematology, 2010, 115, pp.2177-2185

A recent report demonstrated that free human T-cell leukemia virus 1 (HTLV-1) could infect plasmacytoid dendritic cells (pDCs). The major role of pDCs is to secrete massive levels of interferon-α (IFN-α) upon virus exposure; however, the induction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25de7426d0b463328339c189bc5c1cbd
https://doi.org/10.1182/blood-2009-06-224741

In situ synchrotron characterization of mechanically activated self-propagating high-temperature synthesis applied in Mo–Si system

Autor: Frédéric Bernard, Frederic Charlot, Christophe Gras, Jean-Claude Niepce, Eric Gaffet

Publikováno v: Acta Materialia. 47:2113-2123

An original experiment was designed to monitor structural and thermal evolutions during the MASHS (Mechanically Activated Self-propagating High-temperature Synthesis) process in the Mo–Si system. Time-Resolved X-Ray Diffraction (TRXRD) coupled with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::291fa8177dd860bbf50664beeae82bb1
https://doi.org/10.1016/s1359-6454(99)00084-1