Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Christophe Goncalves"'
Autor:
Madelyn J. Abraham, Christophe Goncalves, Paige McCallum, Vrinda Gupta, Samuel E. J. Preston, Fan Huang, Hsiang Chou, Natascha Gagnon, Nathalie A. Johnson, Wilson H. Miller, Koren K. Mann, Sonia V. del Rincon
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-22 (2024)
Abstract Background The tumour microenvironment (TME) consists of tumour-supportive immune cells, endothelial cells, and fibroblasts. PhenoCycler, a high-plex single cell spatial biology imaging platform, is used to characterize the complexity of the
Externí odkaz:
https://doaj.org/article/6fa7d5ed303140b2a9d3879799bd4241
Autor:
Tingting Chen, Marie Hudson, Rejean Lapointe, Wilson H Miller, Pamela Thebault, Khashayar Esfahani, Jun Ding, Lucas A Salas, Steph A Pang, Manuel Flores Molina, Hsiang Chou, Christophe Goncalves, Paulo Nunes Filho, Sabin Filimon, Caroline M Michel, Sonia VDel Rincon
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/55c2d868a2274df890da2bde8d0b8327
Autor:
Fan Huang, Feiyang Cai, Michael S. Dahabieh, Kshemaka Gunawardena, Ali Talebi, Jonas Dehairs, Farah El-Turk, Jae Yeon Park, Mengqi Li, Christophe Goncalves, Natascha Gagnon, Jie Su, Judith H. LaPierre, Perrine Gaub, Jean-Sébastien Joyal, John J. Mitchell, Johannes V. Swinnen, Wilson H. Miller Jr., Sonia V. del Rincón
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 20 (2023)
Melanomas reprogram their metabolism to rapidly adapt to therapy-induced stress conditions, allowing them to persist and ultimately develop resistance. We report that a subpopulation of melanoma cells tolerate MAPK pathway inhibitors (MAPKis) through
Externí odkaz:
https://doaj.org/article/e5c132d7799e4f61987d7324df43d14f
Autor:
Estelle Simo Cheyou, Jacopo Boni, Jonathan Boulais, Edgar Pinedo-Carpio, Abba Malina, Dana Sherill-Rofe, Vincent M Luo, Christophe Goncalves, Halil Bagci, Alexandra Maters, Raquel Cuella-Martin, Yuval Tabach, Sonia Del Rincon, Jean-Francois Côté, Barbara Rivera, Alexandre Orthwein
Publikováno v:
PLoS Genetics, Vol 18, Iss 11, p e1010495 (2022)
Homologous recombination (HR) plays an essential role in the maintenance of genome stability by promoting the repair of cytotoxic DNA double strand breaks (DSBs). More recently, the HR pathway has emerged as a core component of the response to replic
Externí odkaz:
https://doaj.org/article/4cdde5847f534e37a95404622965275b
Autor:
Sai Sakktee Krisna, Christophe Goncalves, Natascha Gagnon, Fan Huang, Dany Plourde, Wilson H. Miller, Jr., Jörg H. Fritz, Sonia V. del Rincon
Publikováno v:
STAR Protocols, Vol 2, Iss 3, Pp 100627- (2021)
Summary: While isolating immune cells from spleens and lungs is routinely achieved using flow cytometry, it is challenging to isolate viable immune cells from skin. Here, we describe a step-by-step protocol for skin digestion using a murine melanoma
Externí odkaz:
https://doaj.org/article/e42b3110fea44832a87ede203d358677
Autor:
Georgia Mitsa, Qianyu Guo, Christophe Goncalves, Samuel E. J. Preston, Vincent Lacasse, Adriana Aguilar-Mahecha, Naciba Benlimame, Mark Basik, Alan Spatz, Gerald Batist, Wilson H. Miller, Sonia V. del Rincon, René P. Zahedi, Christoph H. Borchers
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 8, p 4443 (2022)
Most human tumor tissues that are obtained for pathology and diagnostic purposes are formalin-fixed and paraffin-embedded (FFPE). To perform quantitative proteomics of FFPE samples, paraffin has to be removed and formalin-induced crosslinks have to b
Externí odkaz:
https://doaj.org/article/e4948b417d7c4fd386dfbbaadf5b2a4d
Autor:
Ryan N. Rys, Claudia M. Wever, Dominique Geoffrion, Christophe Goncalves, Artin Ghassemian, Eugene Brailovski, Jeremy Ryan, Liliana Stoica, Josée Hébert, Tina Petrogiannis-Haliotis, Svetlana Dmitrienko, Saul Frenkiel, Annette Staiger, German Ott, Christian Steidl, David W. Scott, Pierre Sesques, Sonia del Rincon, Koren K. Mann, Anthony Letai, Nathalie A. Johnson
Publikováno v:
Cancers, Vol 13, Iss 5, p 1002 (2021)
To determine causes of apoptotic resistance, we analyzed 124 primary B cell NHL samples using BH3 profiling, a technique that measures the mitochondrial permeabilization upon exposure to synthetic BH3 peptides. Our cohort included samples from chroni
Externí odkaz:
https://doaj.org/article/123070e75a91428ea3297b90a91d8878
Autor:
Fan Huang, Feiyang Cai, Michael S. Dahabieh, Kshemaka Gunawardena, Ali Talebi, Jonas Dehairs, Farah El-Turk, Jae Yeon Park, Christophe Goncalves, Natascha Gagnon, Jie Su, Perrine Gaub, Jean-Sébastien Joyal, John J Mitchell, Johannes V Swinnen, Wilson H. Miller, Sonia V. del Rincón
Melanomas reprogram their metabolism to rapidly adapt to therapy-induced stress conditions, allowing them to persist and ultimately develop resistance. We report that a subpopulation of melanoma cells tolerate MAPK pathway inhibitors (MAPKi) through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aeb6883f6988c96df6cf18d5fef4d11c
https://doi.org/10.1101/2022.10.25.513718
https://doi.org/10.1101/2022.10.25.513718
Autor:
Réjean Lapointe, Yao Zhan, Elie Khoury, Yirui Gui, Liesbeth Lenaerts, Dany Plourde, Margarita Bartish, Jörg H. Fritz, Sai Sakktee Krisna, Shannon A. Hewgill, Charles C.T. Hindmarch, Fan Huang, Tiziana Cotechini, Sonia V. del Rincón, Samuel E. J. Preston, Jie Su, Daniela F. Quail, Frédéric Amant, Claudia U. Duerr, Christophe Goncalves, Wilson H. Miller, Barbara C. Mindt, Giuseppe Floris, William Yang, Julian Smith-Voudouris, Qianyu Guo, Mark Basik, Vivian Zihui Li, Hanne Lefrère, Pamela Thebault, Valeria Narykina, Audrey Emond, Aurélie Cleret-Buhot, Yuhong Wei
Publikováno v:
Cancer research, 81(14), 3876-3889. American Association for Cancer Research Inc.
Breast cancer diagnosed within 10 years following childbirth is defined as postpartum breast cancer (PPBC) and is highly metastatic. Interactions between immune cells and other stromal cells within the involuting mammary gland are fundamental in faci
Autor:
Nancy Braverman, Elie Khoury, Erminia Di Pietro, Sathyen A. Prabhu, Alicia M. Bolt, François-Michel Boisvert, Fan Huang, Sonia V. del Rincón, John K. Heath, Wilson H. Miller, Koren K. Mann, Raúl Ernesto Flores González, Alexandre Orthwein, Christophe Goncalves, Zi Yi Xu, Michael S. Dahabieh, Joelle Rémy-Sarrazin
Publikováno v:
Autophagy
Promoting the macroautophagy/autophagy-mediated degradation of specific proteins and organelles can potentially be utilized to induce apoptosis in cancer cells or sensitize tumor cells to therapy. To examine this concept, we enriched for autophagosom