Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Christophe Glorieux"'
Autor:
Christophe Glorieux, Xiaojun Xia, Xin You, Zining Wang, Yi Han, Jing Yang, Gauthier Noppe, Christophe de Meester, Jianhua Ling, Annie Robert, Hui Zhang, Sheng-Ping Li, Huamin Wang, Paul J. Chiao, Li Zhang, Xiaobing Li, Peng Huang
Publikováno v:
Journal of Advanced Research, Vol 40, Iss , Pp 109-124 (2022)
Introduction: Immunochemotherapy using PD-1/PD-L1 antibodies in combination with chemotherapeutic agents has become a mainstream treatment for cancer patients, but it remains unclear which drug combinations would produce best therapeutic outcome. Obj
Externí odkaz:
https://doaj.org/article/31e4ae69c8a84d92ae62b9fc4d2e23ad
Autor:
Christophe Glorieux, Cinthya Enríquez, Constanza González, Gabriela Aguirre-Martínez, Pedro Buc Calderon
Publikováno v:
Antioxidants, Vol 13, Iss 1, p 70 (2024)
Physiological concentrations of reactive oxygen species (ROS) play vital roles in various normal cellular processes, whereas excessive ROS generation is central to disease pathogenesis. The nuclear factor erythroid 2-related factor 2 (NRF2) is a crit
Externí odkaz:
https://doaj.org/article/3bb5b5c3677f4c80b64cfa479345457e
Autor:
Peiting Zeng, Wenhua Lu, Jingyu Tian, Shuang Qiao, Jiangjiang Li, Christophe Glorieux, Shijun Wen, Hui Zhang, Yiqing Li, Peng Huang
Publikováno v:
Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-22 (2022)
Abstract Background Isocitrate dehydrogenase-2 (IDH2) is a mitochondrial enzyme that catalyzes the metabolic conversion between isocitrate and alpha-ketoglutarate (α-KG) in the TCA cycle. IDH2 mutation is an oncogenic event in acute myeloid leukemia
Externí odkaz:
https://doaj.org/article/b4e0b36914e841f693d11684c14dc61a
Publikováno v:
Cancer Communications, Vol 41, Iss 5, Pp 432-435 (2021)
Externí odkaz:
https://doaj.org/article/cd90b9c5bdd24153b5e12effaa17b0e5
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11721 (2022)
Oncogenic K-ras is often activated in pancreatic ductal adenocarcinoma (PDAC) due to frequent mutation (>90%), which drives multiple cellular processes, including alterations in lipid metabolism associated with a malignant phenotype. However, the rol
Externí odkaz:
https://doaj.org/article/12c96ae61e7240a7a16a86eab67fc058
Autor:
Xin You, Jingyu Tian, Hui Zhang, Yunhua Guo, Jing Yang, Chaofeng Zhu, Ming Song, Peng Wang, Zexian Liu, John Cancilla, Wenhua Lu, Christophe Glorieux, Shijun Wen, Hongli Du, Peng Huang, Yumin Hu
Publikováno v:
Molecular Metabolism, Vol 48, Iss , Pp 101203- (2021)
Objective: Mitochondrial aconitase (ACO2) is an essential enzyme that bridges the TCA cycle and lipid metabolism. However, its role in cancer development remains to be elucidated. The metabolic subtype of colorectal cancer (CRC) was recently establis
Externí odkaz:
https://doaj.org/article/2c7a9a6ea3f74273b314f1ac9491312b
Autor:
Christophe Glorieux, Peng Huang
Publikováno v:
Cancer Communications, Vol 39, Iss 1, Pp 1-3 (2019)
Externí odkaz:
https://doaj.org/article/2b8365da86d94018befc090c68f5b431
Autor:
Christophe Glorieux, Peng Huang
Publikováno v:
Cancer Communications, Vol 39, Iss 1, Pp 1-11 (2019)
Abstract Background The interaction between CD137 and its ligand (CD137L) plays a major role in the regulation of immune functions and affects cancer immunotherapy. CD137 is a cell surface protein mainly located on activated T cells, and its regulati
Externí odkaz:
https://doaj.org/article/0557979dbd21466ab387605fa3f7d6a5
Autor:
Christophe Glorieux, Xiaojun Xia, Yong-Qiao He, Yumin Hu, Kelly Cremer, Annie Robert, Junchen Liu, Fen Wang, Jianhua Ling, Paul J. Chiao, Peng Huang
Publikováno v:
Redox Biology, Vol 38, Iss , Pp 101780- (2021)
K-ras mutations are major genetic events that drive cancer development associated with aggressive malignant phenotypes, while expression of the immune checkpoint molecule PD-L1 plays a key role in cancer evasion of the immune surveillance that also p
Externí odkaz:
https://doaj.org/article/0f0079eb86ad4438a2e8999cb2d67cbf
Publikováno v:
Cancer Cell International, Vol 18, Iss 1, Pp 1-9 (2018)
Abstract Background Pro-oxidant drugs have been proposed for treating certain cancers but the resistance developed by cancer cells to oxidative stress limits its potential use in clinics. To understand the mechanisms underlying resistance to oxidativ
Externí odkaz:
https://doaj.org/article/ce2e4987f30c4bcda50baa888562cb17