Zobrazeno 1 - 10
of 207
pro vyhledávání: '"Christophe Ginestier"'
Autor:
Antonin Serrano, Tom Weber, Jean Berthelet, Farrah El-Saafin, Sreeja Gadipally, Emmanuelle Charafe-Jauffret, Christophe Ginestier, John M. Mariadason, Samantha R. Oakes, Kara Britt, Shalin H. Naik, Delphine Merino
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract Intratumoural heterogeneity is associated with poor outcomes in breast cancer. To understand how malignant clones survive and grow in metastatic niches, in vivo models using cell lines and patient-derived xenografts (PDX) have become the gol
Externí odkaz:
https://doaj.org/article/73f9b7ac183444b3acdb9541e95da71a
Autor:
Sonia Pastor, Julien Wicinski, Emmanuelle Charafe-Jauffret, Els Verhoeyen, Geoffrey Guittard, Christophe Ginestier
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 102055- (2023)
Summary: Primary human mammary epithelial cells (pHMECs) are known to be remarkably difficult to engineer genetically. Here, we present a protocol for efficient transduction of pHMECs using a baboon retroviral envelope glycoprotein for pseudotyping o
Externí odkaz:
https://doaj.org/article/35b2daa7600e4e67ae1d01e3ab26a669
Autor:
Violette Azzoni, Julien Wicinski, Manon Macario, Martin Castagné, Pascal Finetti, Katerina Ambrosova, Célia D. Rouault, Arnaud Sergé, Anne Farina, Emilie Agavnian, Sergiu Coslet, Emmanuelle Josselin, Arnaud Guille, José Adelaide, Emmanouil Zacharioudakis, Rémy Castellano, Francois Bertucci, Daniel Birnbaum, Raphael Rodriguez, Emmanuelle Charafe-Jauffret, Christophe Ginestier
Publikováno v:
Cell Death and Disease, Vol 13, Iss 2, Pp 1-15 (2022)
Abstract Replication stress (RS) has a pivotal role in tumor initiation, progression, or therapeutic resistance. In this study, we depicted the mechanism of breast cancer stem cells’ (bCSCs) response to RS and its clinical implication. We demonstra
Externí odkaz:
https://doaj.org/article/41f1ef2e00194644a397b32092889d81
Autor:
Louciné Mitoyan, Véronique Chevrier, Hector Hernandez-Vargas, Alexane Ollivier, Zeinab Homayed, Julie Pannequin, Flora Poizat, Cécile De Biasi-Cador, Emmanuelle Charafe-Jauffret, Christophe Ginestier, Géraldine Guasch
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Transition zones connect distinct epithelia, contain cells expressing stem cell markers, and contribute to cancer development. Here, the authors examine the mouse anorectal junction, identifying a population of Krt17-positive basal cells that contrib
Externí odkaz:
https://doaj.org/article/296e414aa37a402286028e30347ff680
Autor:
Jean-Philippe Guégan, Justine Pollet, Christophe Ginestier, Emmanuelle Charafe-Jauffret, Marcus E. Peter, Patrick Legembre
Publikováno v:
iScience, Vol 24, Iss 12, Pp 103538- (2021)
Summary: CD95 expression is preserved in triple-negative breast cancers (TNBCs), and CD95 loss in these cells triggers the induction of a pro-inflammatory program, promoting the recruitment of cytotoxic NK cells impairing tumor growth. Herein, we ide
Externí odkaz:
https://doaj.org/article/0135437ddb274417b8e1fbb80b8b4c7e
Autor:
Abdul S. Qadir, Jean Philippe Guégan, Christophe Ginestier, Assia Chaibi, Alban Bessede, Emmanuelle Charafe-Jauffret, Manon Macario, Vincent Lavoué, Thibault de la Motte Rouge, Calvin Law, Jacob Vilker, Hongbin Wang, Emily Stroup, Matthew J. Schipma, Bryan Bridgeman, Andrea E. Murmann, Zhe Ji, Patrick Legembre, Marcus E. Peter
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103348- (2021)
Summary: The apoptosis inducing receptor CD95/Fas has multiple tumorigenic activities. In different genetically engineered mouse models tumor-expressed CD95 was shown to be critical for cell growth. Using a combination of immune-deficient and immune-
Externí odkaz:
https://doaj.org/article/01c1b9341da244a5b4a9946be1c614bf
Autor:
Jean Berthelet, Momeneh Foroutan, Dharmesh D. Bhuva, Holly J. Whitfield, Farrah El-Saafin, Joseph Cursons, Antonin Serrano, Michal Merdas, Elgene Lim, Emmanuelle Charafe-Jauffret, Christophe Ginestier, Matthias Ernst, Frédéric Hollande, Robin L. Anderson, Bhupinder Pal, Belinda Yeo, Melissa J. Davis, Delphine Merino
Publikováno v:
Cancers, Vol 14, Iss 10, p 2404 (2022)
The development of therapies that target specific disease subtypes has dramatically improved outcomes for patients with breast cancer. However, survival gains have not been uniform across patients, even within a given molecular subtype. Large collect
Externí odkaz:
https://doaj.org/article/03fba90710854702b0036094e42aa149
Autor:
Leonor Lopez Almeida, Michael Sebbagh, François Bertucci, Pascal Finetti, Julien Wicinski, Sylvie Marchetto, Rémy Castellano, Emmanuelle Josselin, Emmanuelle Charafe-Jauffret, Christophe Ginestier, Jean-Paul Borg, Marie-Josée Santoni
Publikováno v:
Stem Cell Reports, Vol 11, Iss 5, Pp 1040-1050 (2018)
Summary: Tumor initiation, progression, and therapeutic resistance have been proposed to originate from a subset of tumor cells, cancer stem cells (CSCs). However, the current understanding of the mechanisms involved in their self-renewal and tumor i
Externí odkaz:
https://doaj.org/article/719bdd3e4c6a4ee98eed7cf72b140fc3
Autor:
Rita El Helou, Guillaume Pinna, Olivier Cabaud, Julien Wicinski, Ricky Bhajun, Laurent Guyon, Claire Rioualen, Pascal Finetti, Abigaelle Gros, Bernard Mari, Pascal Barbry, Francois Bertucci, Ghislain Bidaut, Annick Harel-Bellan, Daniel Birnbaum, Emmanuelle Charafe-Jauffret, Christophe Ginestier
Publikováno v:
Cell Reports, Vol 18, Iss 9, Pp 2256-2268 (2017)
Summary: Breast cancer stem cells (bCSCs) have been implicated in tumor progression and therapeutic resistance; however, the molecular mechanisms that define this state are unclear. We have performed two microRNA (miRNA) gain- and loss-of-function sc
Externí odkaz:
https://doaj.org/article/46925da2e0104ddc8a207b5df794202d
Autor:
Abir Arfaoui, Claire Rioualen, Violette Azzoni, Guillaume Pinna, Pascal Finetti, Julien Wicinski, Emmanuelle Josselin, Manon Macario, Rémy Castellano, Candi Léonard‐Stumpf, Anthony Bal, Abigaelle Gros, Sylvain Lossy, Maher Kharrat, Yves Collette, Francois Bertucci, Daniel Birnbaum, Hayet Douik, Ghislain Bidaut, Emmanuelle Charafe‐Jauffret, Christophe Ginestier
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 10, Pp n/a-n/a (2019)
Abstract Therapeutic resistance is a major clinical challenge in oncology. Evidence identifies cancer stem cells (CSCs) as a driver of tumor evolution. Accordingly, the key stemness property unique to CSCs may represent a reservoir of therapeutic tar
Externí odkaz:
https://doaj.org/article/c9002abaa4bb472dafea9936d6b75e8c