Výsledky vyhledávání - "Christophe Genisset"

The Cell-Specific Phenotype of the Polymorphic vacA Midregion Is Independent of the Appearance of the Cell Surface Receptor Protein Tyrosine Phosphatase β

Autor: John L. Telford, David A. G. Skibinski, Christophe Genisset, Silvia Barone

Publikováno v: Infection and Immunity. 74:49-55

There are two alleles, m1 and m2, of the midregion of the vacuolating cytotoxin gene ( vacA ) of Helicobacter pylori which code for toxins with different cell specificities. Here we describe the construction of five chimeric strains in which regions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c162e39ca5c8ddc3f3df2512bb0d5fc4
https://doi.org/10.1128/iai.74.1.49-55.2006

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Endosome-mitochondria juxtaposition during apoptosis induced by H. pylori VacA

Autor: M. Rossato, Luca Scorrano, Alessandro Casellato, F. Calore, Mauro Degli Esposti, M. De Bernard, Gaia Codolo, Christophe Genisset

Publikováno v: Cell Death and Differentiation, Vol. 17, No 11 (2010) pp. 1707-1716

The vacuolating cytotoxin (VacA) is an important virulence factor of Helicobacter pylori with pleiotropic effects on mammalian cells, including the ability to trigger mitochondria-dependent apoptosis. However, the mechanism by which VacA exerts its a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a403d95f7c1d68872a8466bc32794053
http://hdl.handle.net/11577/2446808

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The concerted action of the Helicobacter pylori cytotoxin VacA and of the v-ATPase proton pump induces swelling of isolated endosomes

Autor: Andrea Puhar, Federica Calore, Marina de Bernard, Cesare Montecucco, Christophe Genisset, Paolo Dell'Antone

Publikováno v: Cellular microbiology. 9(6)

The vacuolating cytotoxin (VacA) is a major virulence factor of Helicobacter pylori, the bacterium associated to gastroduodenal ulcers and stomach cancers. VacA induces formation of cellular vacuoles that originate from late endosomal compartments. V

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::547afb4781500495cca5ab173e1528ae
https://pubmed.ncbi.nlm.nih.gov/17253977

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A Helicobacter pylori vacuolating toxin mutant that fails to oligomerize has a dominant negative phenotype

Autor: Roberto Battistutta, John L. Telford, David Mercati, Cesira Galeotti, Pietro Lupetti, David A. G. Skibinski, Marina de Bernard, Christophe Genisset, Silvia Barone

Most Helicobacter pylori strains secrete a toxin (VacA) that causes massive vacuolization of target cells and which is a major virulence factor of H. pylori . The VacA amino-terminal region is required for the induction of vacuolization. The aim of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b923e5abf53dcedf8c7b88e8cf7a3bb7
http://hdl.handle.net/11365/1063994

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