Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Christophe G Lambert"'
Autor:
Samuel B. Anyona, Qiuying Cheng, Sharley A. Wasena, Shamim W. Osata, Yan Guo, Evans Raballah, Ivy Hurwitz, Clinton O. Onyango, Collins Ouma, Philip D. Seidenberg, Benjamin H. McMahon, Christophe G. Lambert, Kristan A. Schneider, Douglas J. Perkins
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract This study on severe malarial anemia (SMA: Hb < 6.0 g/dL), a leading global cause of childhood morbidity and mortality, compares the entire expressed whole blood host transcriptome between Kenyan children (3-48 mos.) with non-SMA (Hb ≥ 6.0
Externí odkaz:
https://doaj.org/article/2622e5cda8f8454d886f8c9629fbe735
Autor:
Vincent T. Metzger, Daniel C. Cannon, Jeremy J. Yang, Stephen L. Mathias, Cristian G. Bologa, Anna Waller, Stephan C. Schürer, Dušica Vidović, Keith J. Kelleher, Timothy K. Sheils, Lars Juhl Jensen, Christophe G. Lambert, Tudor I. Oprea, Jeremy S. Edwards
Publikováno v:
PeerJ, Vol 12, p e17470 (2024)
TIN-X (Target Importance and Novelty eXplorer) is an interactive visualization tool for illuminating associations between diseases and potential drug targets and is publicly available at newdrugtargets.org. TIN-X uses natural language processing to i
Externí odkaz:
https://doaj.org/article/960d5f8e591045c1b0baec822e03ab67
Autor:
Nori Matsunami, Dexter Hadley, Charles H Hensel, G Bryce Christensen, Cecilia Kim, Edward Frackelton, Kelly Thomas, Renata Pellegrino da Silva, Jeff Stevens, Lisa Baird, Brith Otterud, Karen Ho, Tena Varvil, Tami Leppert, Christophe G Lambert, Mark Leppert, Hakon Hakonarson
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e52239 (2013)
Structural variation is thought to play a major etiological role in the development of autism spectrum disorders (ASDs), and numerous studies documenting the relevance of copy number variants (CNVs) in ASD have been published since 2006. To determine
Externí odkaz:
https://doaj.org/article/8f019b4696504a81b6489786168f61ab
Autor:
Huixiao Hong, Lei Xu, Jie Liu, Wendell D Jones, Zhenqiang Su, Baitang Ning, Roger Perkins, Weigong Ge, Kelci Miclaus, Li Zhang, Kyunghee Park, Bridgett Green, Tao Han, Hong Fang, Christophe G Lambert, Silvia C Vega, Simon M Lin, Nadereh Jafari, Wendy Czika, Russell D Wolfinger, Federico Goodsaid, Weida Tong, Leming Shi
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44483 (2012)
During the last several years, high-density genotyping SNP arrays have facilitated genome-wide association studies (GWAS) that successfully identified common genetic variants associated with a variety of phenotypes. However, each of the identified ge
Externí odkaz:
https://doaj.org/article/f7b0abb5339e435fa63dd591f9847118
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28477 (2011)
Bipolar disorder is a severe psychiatric disorder with high heritability. Co-morbid conditions are common and might define latent subgroups of patients that are more homogeneous with respect to genetic risk factors.In the Caucasian GAIN bipolar disor
Externí odkaz:
https://doaj.org/article/aa603f41e34744ac907c345e7810b7ec
Autor:
Clinton O. Onyango, Qiuying Cheng, Elly O. Munde, Evans Raballah, Samuel B. Anyona, Benjamin H. McMahon, Christophe G. Lambert, Patrick O. Onyango, Kristan A. Schneider, Douglas J. Perkins, Collins Ouma
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-11 (2023)
Abstract Background Plasmodium falciparum malaria is a leading cause of pediatric morbidity and mortality in holoendemic transmission areas. Severe malarial anemia [SMA, hemoglobin (Hb) G and rs11575837:C > T) and their haplotypes. The prospective ob
Externí odkaz:
https://doaj.org/article/50746c71127340239df9137a3ea899c9
Autor:
John Erol Evangelista, Daniel J. B. Clarke, Zhuorui Xie, Giacomo B. Marino, Vivian Utti, Sherry L. Jenkins, Taha Mohseni Ahooyi, Cristian G. Bologa, Jeremy J. Yang, Jessica L. Binder, Praveen Kumar, Christophe G. Lambert, Jeffrey S. Grethe, Eric Wenger, Deanne Taylor, Tudor I. Oprea, Bernard de Bono, Avi Ma’ayan
Publikováno v:
Communications Medicine, Vol 3, Iss 1, Pp 1-14 (2023)
Abstract Background Birth defects are functional and structural abnormalities that impact about 1 in 33 births in the United States. They have been attributed to genetic and other factors such as drugs, cosmetics, food, and environmental pollutants d
Externí odkaz:
https://doaj.org/article/3b529ae9cc3f41ad82da2371efbd1a29
Autor:
Lily E. Kisia, Qiuying Cheng, Evans Raballah, Elly O. Munde, Benjamin H. McMahon, Nick W. Hengartner, John M. Ong’echa, Kiprotich Chelimo, Christophe G. Lambert, Collins Ouma, Prakasha Kempaiah, Douglas J. Perkins, Kristan A. Schneider, Samuel B. Anyona
Publikováno v:
Tropical Medicine and Health, Vol 50, Iss 1, Pp 1-15 (2022)
Abstract Plasmodium falciparum infections remain among the leading causes of morbidity and mortality in holoendemic transmission areas. Located within region 5q31.1, the colony-stimulating factor 2 gene (CSF2) encodes granulocyte–macrophage colony-
Externí odkaz:
https://doaj.org/article/9181a3a765424ab5950663800c7efad4
Autor:
Nicolas R. Lauve, Stuart J. Nelson, S. Stanley Young, Robert L. Obenchain, Christophe G. Lambert
Publikováno v:
Journal of Statistical Software, Vol 96, Iss 1, Pp 1-32 (2020)
The LocalControl R package implements novel approaches to address biases and confounding when comparing treatments or exposures in observational studies of outcomes. While designed and appropriate for use in comparative safety and effectiveness resea
Externí odkaz:
https://doaj.org/article/3ca3d74232e34e5699cf1b023518b22c
Autor:
Lily E. Kisia, Prakasha Kempaiah, Samuel B. Anyona, Elly O. Munde, Angela O. Achieng, John M. Ong’echa, Christophe G. Lambert, Kiprotich Chelimo, Collins Ouma, Douglas J. Perkins, Evans Raballah
Publikováno v:
BMC Medical Genetics, Vol 20, Iss 1, Pp 1-10 (2019)
Abstract Background Severe malarial anemia (SMA) is a leading cause of malaria-related morbidity and mortality in children. The genetic factors that influence development of SMA and inefficient erythropoiesis, a central pathogenic feature of SMA, are
Externí odkaz:
https://doaj.org/article/d64936deb1244e07876c59d122a1102c