Supercritical fluid chromatographic chiral separation of potential P2RX7 antagonists containing one, two and three chiral centers

Autor: Naomi KNAVS, Andreea ZUBAŞ, Georgiana APOSTOL, Christophe FURMAN, Adrian Sorin NICA, Bezhan CHANKVETADZE, Alina GHINET, Emmanuelle LIPKA

Publikováno v: Journal of Chromatography Open, Vol 5, Iss , Pp 100129- (2024)

Eleven polysaccharide-based chiral stationary phases were screened to separate stereoisomers of six lactam derivatives by supercritical fluid chromatography (SFC). Those molecules are antagonists of the P2×7 receptor with potential anti-inflammatory

Externí odkaz: https://doaj.org/article/868d52519edd4a5aa8bb00a9fd5ac45f

Sustainability in drug discovery

Autor: Evelien Wynendaele, Christophe Furman, Bartosz Wielgomas, Per Larsson, Eelko Hak, Thomas Block, Serge Van Calenbergh, Nicolas Willand, Michal Markuszewski, Luke R. Odell, Gerrit J. Poelarends, Bart De Spiegeleer

Publikováno v: Medicine in Drug Discovery, Vol 12, Iss , Pp 100107- (2021)

Due to the expanding and ageing world population, the importance and use of medicines is expected to increase. However, this will lead to a greater impact on the ecosystem and our health in the long term.The concept of sustainability is rather slowly

Externí odkaz: https://doaj.org/article/5a33ad31471a408795ab5e204a5d6c7d

Separation of planar chiral ferrocenes by capillary electrokinetic chromatography and liquid chromatography

Autor: Antoine Morvan, Camille Garnier, Christophe Furman, David Speybrouck, Eric Boulanger, Alina Ghinet, Emmanuelle Lipka

Publikováno v: Journal of chromatography. A. 1677

Capillary electrokinetic chromatography (CEKC) and liquid chromatography (LC) methods were explored for the enantiomeric separation of six unsymmetrically disubstituted ferrocene derivatives. In normal-phase mode liquid chromatography, the use of n-h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e9b35ab13396c0a6554ab845fd5cc5
https://pubmed.ncbi.nlm.nih.gov/35810641

A small-molecule P2RX7 activator promotes anti-tumor immune responses and sensitizes lung tumor to immunotherapy

Autor: Jonathan Benzaquen, Jean Kanellopoulos, Nicolas Renault, Christophe Duranton, Cécile Delarasse, Sahil Adriouch, Alina Ghinet, Bernhard Ryffel, Christophe Furman, Régis Millet, Laetitia Seguin, Serena Janho Dit Hreich, Chloé C. Féral, Thierry Juhel, Julien Cherfils-Vicini, Paul Hofman, Germain Homerin, Xavier Dezitter, Valérie Vouret-Craviari, Laetitia Douguet

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.653. ⟨10.1038/s41467-021-20912-2⟩
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications, 2021, 12 (1), pp.653. ⟨10.1038/s41467-021-20912-2⟩

Only a subpopulation of non-small cell lung cancer (NSCLC) patients responds to immunotherapies, highlighting the urgent need to develop therapeutic strategies to improve patient outcome. We develop a chemical positive modulator (HEI3090) of the puri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca73021f6590531e19ceaff84cd00c1a
https://hal.sorbonne-universite.fr/hal-03126997/document

Electrophoretic separation of multiple chiral center analyte with a three cyclodextrins mixture

Autor: Cécile Danel, Christophe Furman, Julie Charton, Zuo La, Emmanuelle Lipka, Gaëlle Grolaux

Publikováno v: Electrophoresis5 References. 42(17-18)

A capillary electrokinetic chromatography method (CEKC) was developed for complete stereoisomeric separation of a neutral, hydrophobic, multiple chiral center dihydropyridone analogue, a drug candidate proposed in type 2 diabetes treatment. A backgro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a3bade215266fca49f0efe1195f8375
https://pubmed.ncbi.nlm.nih.gov/33644914