Výsledky vyhledávání - "Christophe Dussouy"

A dansyl-derivatized phytic acid analogue as a fluorescent substrate for phytases: experimental and computational approach

Autor: Claude Plassard, Herve Quiquampoix, Patrick Chemardin, Josiane Abadie, Jean-Bernard Behr, Christophe Dussouy, Eric Dubreucq, Véronique Perrier

Publikováno v: Bioorganic Chemistry
Bioorganic Chemistry, Elsevier, 2021, 110, ⟨10.1016/j.bioorg.2021.104810⟩
Bioorganic Chemistry, 2021, 110, ⟨10.1016/j.bioorg.2021.104810⟩

International audience; A new myo-inositol pentakisphosphate was synthesized, which featured a dansyl group at position C-5. The fluorescent tag was removed from the inositol by a 6-atom spacer to prevent detrimental steric interactions in the cataly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b43b88cba66828062ca38579d576cb
https://hal.inrae.fr/hal-03259389

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Hexavalent thiofucosides to probe the role of the Aspergillus fumigatus lectin FleA in fungal pathogenicity

Autor: Aurore Cabanettes, David Deniaud, Annabelle Varrot, Viviane Balloy, Sébastien G. Gouin, Victor Lehot, Emilie Gillon, Christophe Dussouy, Pierre-Alban Lalys

Publikováno v: Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2021, 19 (14), pp.3234-3240. ⟨10.1039/D1OB00152C⟩

International audience; A. fumigatus is a pathogenic fungus infecting the respiratory system and responsible for a variety of life-threatening lung diseases. A fucose-binding lectin named FleA which has a controversial role in A. fumigatus pathogenes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb92ae70430c576439435e95fa347970
https://pubmed.ncbi.nlm.nih.gov/33885578

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Access to Galectin-3 Inhibitors from Chemoenzymatic Synthons

Autor: Cathy Charlier, Christophe Dussouy, Cyrille Grandjean, Stéphane Téletchéa, Annie Lambert, Frédéric De Ceuninck, I. Botez

Publikováno v: Journal of Organic Chemistry
Journal of Organic Chemistry, American Chemical Society, 2020, ⟨10.1021/acs.joc.0c01927⟩

International audience; Chemo-enzymatic strategies are useful to provide both regio-and stereoselective access to bioactive oligosaccharides. We show herein that a glycosynthase mutant of a Thermus thermophilus -glycosidase can react with unnatura

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d412e7888f9041e17033c6239bc946b7
https://pubmed.ncbi.nlm.nih.gov/33200927

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Linear triazole-linked pseudo oligogalactosides as scaffolds for galectin inhibitor development

Autor: Annie Lambert, Clément Lamoureux, Cyrille Grandjean, Chandan Kishor, Helen Blanchard, Christophe Dussouy

Publikováno v: Chemical Biology and Drug Design
Chemical Biology and Drug Design, Wiley, 2020, ⟨10.1111/cbdd.13683⟩

Galectins play key roles in numerous biological processes. Their mode of action depends on their localization which can be extracellular, cytoplasmic, or nuclear and is partly mediated through interactions with β-galactose containing glycans. Galect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91a1744ff0456c4996a9d371ed4be685
https://hal.archives-ouvertes.fr/hal-02990603/file/CBDD-RA-08-19-4810.R1_Proof_fl.pdf

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An In Situ Hyaluronic Acid-Fibrin Hydrogel Containing Drug-Loaded Nanocapsules for Intra-Articular Treatment of Inflammatory Joint Diseases

Autor: Christophe Dussouy, José Crecente-Campo, Madalena Monteiro, María J. Alonso, Sandra Simões, David Cabaleiro, Luis Lugo, Cyrille Grandjean, Nataliya Storozhylova

Publikováno v: Regenerative Engineering and Translational Medicine
Regenerative Engineering and Translational Medicine, Springer, 2020, 6 (2), pp.201-216. ⟨10.1007/s40883-020-00154-2⟩

International audience; Intra-articular (IA) administration of drugs is an appealing route for the effective treatment of large-joint diseases. However, a key limitation of this route is the premature elimination of the injected drugs from the synovi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::214e25109fbbeda78e8d2031d0cc561a
https://hal.archives-ouvertes.fr/hal-02990612/document

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Multivalent Fucosides with Nanomolar Affinity for the Aspergillus fumigatus Lectin FleA Prevent Spore Adhesion to Pneumocytes

Autor: David Deniaud, Sébastien G. Gouin, Emilie Gillon, Patrice Le Pape, Aurore Cabanettes, Annabelle Varrot, Victor Lehot, Yoan Brissonnet, Christophe Dussouy, Sami Brument

Publikováno v: Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, 2018, 24 (72), pp.19243-19249. ⟨10.1002/chem.201803602⟩

FleA (or AFL), a fucose lectin, was recently identified in the opportunistic mold Aspergillus fumigatus, which causes fatal lung infections in immunocompromised patients. We designed di-, hexa- and octavalent fucosides with various spacer arm lengths

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24ddd031ce38a089a75a8b00aed23ee1
https://doi.org/10.1002/chem.201803602

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Development of a Sensitive Microarray Platform for the Ranking of Galectin Inhibitors: Identification of a Selective Galectin-3 Inhibitor

Autor: Mireille Viguier, Charles Tellier, Cyrille Grandjean, Samir Dahbi, Hiroaki Tateno, Frédérique Deshayes, Christophe Dussouy, Tamara Advedissian, Stéphane Téletchéa, Annie Lambert, Jun Hirabayashi, Nataliya Storozhylova, Johann Dion, Françoise Poirier

Publikováno v: ChemBioChem
ChemBioChem, 2017, 18 (24), pp.2428-2440. ⟨10.1002/cbic.201700544⟩
ChemBioChem, Wiley-VCH Verlag, 2017, 18 (24), pp.2428-2440. ⟨10.1002/cbic.201700544⟩

Glycan microarrays are useful tools for lectin glycan profiling. The use of a glycan microarray based on evanescent-field fluorescence detection was herein further extended to the screening of lectin inhibitors in competitive experiments. The efficac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e412277a6a739eccf79c4a0703fc54ba
https://hal.science/hal-02197011

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Lactosamine-Based Derivatives as Tools to Delineate the Biological Functions of Galectins: Application to Skin Tissue Repair

Autor: Annie Lambert, Johann Dion, Cyrille Grandjean, Françoise Poirier, Charles Tellier, Nataliya Storozhylova, Mireille Viguier, Christophe Dussouy, Tamara Advedissian, Frédérique Deshayes

Publikováno v: ChemBioChem
ChemBioChem, Wiley-VCH Verlag, 2017, 18 (8), pp.782-789. ⟨10.1002/cbic.201600673⟩

Galectins have been recognized as potential novel therapeutic targets for the numerous fundamental biological processes in which they are involved. Galectins are key players in homeostasis, and as such their expression and function are finely tuned i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69eb6596e52141302d69a91c96892a3f
https://hal.archives-ouvertes.fr/hal-02197006

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An anionic synthetic sugar containing 6-SO3-NAcGlc mimics the sulfated cruzipain epitope that plays a central role in immune recognition

Autor: Christophe Dussouy, Maximilien Barbier, Laurent Bultel, Maximiliano Ruben Ferrero, Diana Maria Acosta, Juliana Elena Parente, José Kovensky, Malena Landoni, Alicia S. Couto, Luciana Lía Soprano, Marilyne Pourcelot, Mónica Inés Esteva, Vilma G. Duschak

Publikováno v: The FEBS Journal. 279:3665-3679

Cruzipain (Cz), the major cysteine proteinase of Trypanosoma cruzi, is a glycoprotein that contains sulfated high-mannose-type oligosaccharides. We have previously determined that these sulfate groups are targets of specific immune responses. In orde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c2c952337848b7d8da95f2466157547c
https://doi.org/10.1111/j.1742-4658.2012.08728.x

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