Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Christophe C. Marchal"'
Autor:
Karen E. Pollok, Harlan E. Shannon, Christine M. Eischen, Lindsey D. Mayo, George E. Sandusky, Paul R. Territo, Helmut Hanenberg, Ahmad R. Safa, Christopher N. Batuello, Christophe C. Marchal, Robert E. Minto, Eric C. Long, T. Zachary Gunter, Taxiarchis M. Georgiadis, Alyssa A. Sprouse, Jayne M. Silver, Tiaishia K. Spragins, Kacie M. Peterman, Anthony L. Sinn, Haiyan Wang, Jixin Ding, M. Reza Saadatzadeh, Barbara J. Bailey, Eva Tonsing-Carter
Evaluation of pharmacodynamic (PD) markers in vivo.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71a72cc9d6f37a7aa48c1cf0c3ff8000
https://doi.org/10.1158/1535-7163.22503883
https://doi.org/10.1158/1535-7163.22503883
Autor:
Karen E. Pollok, Harlan E. Shannon, Christine M. Eischen, Lindsey D. Mayo, George E. Sandusky, Paul R. Territo, Helmut Hanenberg, Ahmad R. Safa, Christopher N. Batuello, Christophe C. Marchal, Robert E. Minto, Eric C. Long, T. Zachary Gunter, Taxiarchis M. Georgiadis, Alyssa A. Sprouse, Jayne M. Silver, Tiaishia K. Spragins, Kacie M. Peterman, Anthony L. Sinn, Haiyan Wang, Jixin Ding, M. Reza Saadatzadeh, Barbara J. Bailey, Eva Tonsing-Carter
Supplemental Table S1. IC50 values for Nultin-3a, Carboplatin, and 1:1 Combination; Supplemental Material and Methods; Supplemental Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09343e5cb6a5cc54213c520115a729f6
https://doi.org/10.1158/1535-7163.22503880
https://doi.org/10.1158/1535-7163.22503880
Autor:
Neil A. O'Brien, Dennis J. Slamon, Colleen Mockbee, Tong Luo, Kevin Chau, Ondrej Kalous, Ann Mc Nulty, Josh Thomas, Dylan Conklin, Sara A. Hurvitz, Erika von Euw, Christophe C. Marchal, Richard P. Beckmann
Publikováno v:
Molecular Cancer Therapeutics. 17:897-907
The cyclinD:CDK4/6:Rb axis is dysregulated in a variety of human cancers. Targeting this pathway has proven to be a successful therapeutic approach in ER+ breast cancer. In this study, in vitro and in vivo preclinical breast cancer models were used t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e82ec8f3028d6baa5d1d01c99c856746
https://doi.org/10.1158/1535-7163.mct-17-0290
https://doi.org/10.1158/1535-7163.mct-17-0290
Autor:
Madhu Mahankali, Julian Gomez-Cambronero, Christophe C. Marchal, Paula A. Bubulya, Hong-Juan Peng, Karen M. Henkels, Mary C. Dinauer
Publikováno v:
Molecular and Cellular Biology. 31:2227-2240
We document a biphasic effect of Rac2 on the activation and inhibition of PLD2. Cells overexpressing Rac2 and PLD2 simultaneously show a robust initial (10 min) response toward a chemoattractant that is later (30 min) greatly diminished over PLD2-onl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a63b2f61941f95e17101907d7a617f2d
https://doi.org/10.1128/mcb.01348-10
https://doi.org/10.1128/mcb.01348-10
Autor:
Samy O. Meroueh, Christopher C. M. Waterhouse, Iwona Wrobel, Christophe C. Marchal, Mary C. Dinauer, Weiming Yu, Xing Jun Li, Juan D. Matute, Andrés Augusto Arias, Natalie D. Stull, MacGregor Steele, Nicola A.M. Wright, James D. Kellner, William M. Nauseef, David B. Lewis
Publikováno v:
Blood. 114:3309-3315
Chronic granulomatous disease (CGD), an immunodeficiency with recurrent pyogenic infections and granulomatous inflammation, results from loss of phagocyte superoxide production by recessive mutations in any 1 of 4 genes encoding subunits of the phago
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ea28c23eb454b59fd3f619c7b26ddb
https://doi.org/10.1182/blood-2009-07-231498
https://doi.org/10.1182/blood-2009-07-231498
Rac GTPase Isoform-specific Regulation of NADPH Oxidase and Chemotaxis in Murine Neutrophils in Vivo
Autor:
Simon J. Atkinson, Ulla G. Knaus, Jason Towe, Akira Yamauchi, Christophe C. Marchal, Jason K. Molitoris, Nancy Pech, Mary C. Dinauer
Publikováno v:
Journal of Biological Chemistry. 280:953-964
The Rho family GTPase Rac acts as a molecular switch for signal transduction to regulate various cellular functions. Mice deficient in the hematopoietic-specific Rac2 isoform exhibit agonist-specific defects in neutrophil chemotaxis and superoxide pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::213f4496c5671dac39c33191f1e45a95
https://doi.org/10.1074/jbc.m408820200
https://doi.org/10.1074/jbc.m408820200
Autor:
Christophe C. Marchal, Mary C. Dinauer, Akira Yamauchi, Jason Towe, Chaekyun Kim, Shijun Li, Simon J. Atkinson
Publikováno v:
The Journal of Immunology. 173:5971-5979
The Rho family GTPase Rac is a crucial participant in numerous cellular functions and acts as a molecular switch for signal transduction. Mice deficient in hemopoietic-specific Rac2 exhibited agonist-specific defects in neutrophil functions including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af25db48740671b001824067378b7395
https://doi.org/10.4049/jimmunol.173.10.5971
https://doi.org/10.4049/jimmunol.173.10.5971
Autor:
Fei Zhu, Gregory P. Downey, Mary C. Dinauer, Christophe C. Marchal, Björn E. Clausen, Aelaf Worku, Michael Glogauer, David J. Kwiatkowski, Irmgard Foerster, Peter W. Marks
Publikováno v:
Journal of immunology (Baltimore, Md., 170(11), 5652-5657. American Association of Immunologists
ResearcherID
Scopus-Elsevier
ResearcherID
Scopus-Elsevier
Defects in myeloid cell function in Rac2 knockout mice underline the importance of this isoform in activation of NADPH oxidase and cell motility. However, the specific role of Rac1 in neutrophil function has been difficult to assess since deletion of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82b64900d0e198267776d5c9bb0ceaa9
https://doi.org/10.4049/jimmunol.170.11.5652
https://doi.org/10.4049/jimmunol.170.11.5652
Autor:
Christophe C. Marchal, Irene Denning, Peter Edward Vaillancourt, Timothy R. Holzer, Jessica A. Roseberry Baker, Aaron M Gruver, Mark Wortinger, Jirong Lu, Julian Davies, Jeffrey C. Hanson, Sameera R. Wijayawardana, Ling Liu, Megan E Lacy, Andrew E. Schade, Hadrian P. Szpurka, Sau-Chi B. Yan, Joel D. Cook, Erin M Felke, Wei Zeng, Chi-Kin Chow, Emily Rhoads, Kelly M. Credille, Gregory Beuerlein
Publikováno v:
Histopathology. 65(6)
Development of novel targeted therapies directed against hepatocyte growth factor (HGF) or its receptor (MET) necessitates the availability of quality diagnostics to facilitate their safe and effective use. Limitations of some commercially available
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a49e23889656e2ea7274884c9a15c640
https://pubmed.ncbi.nlm.nih.gov/25039923
https://pubmed.ncbi.nlm.nih.gov/25039923
Autor:
Jacinta Bustamante, Andres A Arias, Guillaume Vogt, Capucine Picard, Lizbeth Blancas Galicia, Carolina Prando, Audrey V Grant, Christophe C Marchal, Marjorie Hubeau, Ariane Chapgier, Ludovic de Beaucoudrey, Anne Puel, Jacqueline Feinberg, Ethan Valinetz, Lucile Jannière, Céline Besse, Anne Boland, Jean-Marie Brisseau, Stéphane Blanche, Olivier Lortholary, Claire Fieschi, Jean-François Emile, Stéphanie Boisson-Dupuis, Saleh Al-Muhsen, Bruce Woda, Peter E Newburger, Antonio Condino-Neto, Mary C Dinauer, Laurent Abel, Jean-Laurent Casanova
Las mutaciones de la linea germinal en CYBB, el gen humano que codifica la subunidad gp91phox del fagocito NADPH oxidasa, perjudican el estallido respiratorio de todos los tipos de fagocitos y dan como resultado la enfermedad granulomatosa cronica li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cadff504a747c235f3dfa77102d574a5
https://europepmc.org/articles/PMC3097900/
https://europepmc.org/articles/PMC3097900/