Výsledky vyhledávání - "Christophe Côme"

Akademický článek

SNHG5 promotes colorectal cancer cell survival by counteracting STAU1-mediated mRNA destabilization

Autor: Nkerorema Djodji Damas, Michela Marcatti, Christophe Côme, Lise Lotte Christensen, Morten Muhlig Nielsen, Roland Baumgartner, Helene Maria Gylling, Giulia Maglieri, Carsten Friis Rundsten, Stefan E. Seemann, Nicolas Rapin, Simon Thézenas, Søren Vang, Torben Ørntoft, Claus Lindbjerg Andersen, Jakob Skou Pedersen, Anders H. Lund

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)

Several lncRNAs have been linked to cancer. Here, the authors identify SNHG5 as a long non-coding RNA promoting proliferation and survival of colorectal cancer cells by protecting specific mRNAs from STAU1-mediated degradation.

Externí odkaz: https://doaj.org/article/b798c3c5b5f543a9b6ab76d138075453

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Akademický článek

CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection.

Publikováno v: PLoS ONE, Vol 11, Iss 4, p e0152996 (2016)

The oncoprotein Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A) is overexpressed in most malignancies and is an obvious candidate target protein for future cancer therapies. However, the physiological importance of CIP2A-mediated PP2A inhibitio

Externí odkaz: https://doaj.org/article/3fc34fe0c87f451793b1973405cb17a2

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Akademický článek

Cox4i2, Ifit2, and Prdm11 Mutant Mice: Effective Selection of Genes Predisposing to an Altered Airway Inflammatory Response from a Large Compendium of Mutant Mouse Lines.

Autor: Marion Horsch, Juan Antonio Aguilar-Pimentel, Clemens Bönisch, Christophe Côme, Cathrine Kolster-Fog, Klaus T Jensen, Anders H Lund, Icksoo Lee, Lawrence I Grossman, Christopher Sinkler, Maik Hüttemann, Erwin Bohn, Helmut Fuchs, Markus Ollert, Valérie Gailus-Durner, Martin Hrabĕ de Angelis, Johannes Beckers

Publikováno v: PLoS ONE, Vol 10, Iss 8, p e0134503 (2015)

We established a selection strategy to identify new models for an altered airway inflammatory response from a large compendium of mutant mouse lines that were systemically phenotyped in the German Mouse Clinic (GMC). As selection criteria we included

Externí odkaz: https://doaj.org/article/eb5e849edd9e468185aae4a588743bdb

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Akademický článek

Slug controls stem/progenitor cell growth dynamics during mammary gland morphogenesis.

Autor: Mayssa Nassour, Ysia Idoux-Gillet, Abdelkader Selmi, Christophe Côme, Maria-Luisa M Faraldo, Marie-Ange Deugnier, Pierre Savagner

Publikováno v: PLoS ONE, Vol 7, Iss 12, p e53498 (2012)

Morphogenesis results from the coordination of distinct cell signaling pathways controlling migration, differentiation, apoptosis, and proliferation, along stem/progenitor cell dynamics. To decipher this puzzle, we focused on epithelial-mesenchymal t

Externí odkaz: https://doaj.org/article/3d589e8e4a0f47cb99e9606b902aa77f

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Akademický článek

CIP2A promotes proliferation of spermatogonial progenitor cells and spermatogenesis in mice.

Autor: Sami Ventelä, Christophe Côme, Juho-Antti Mäkelä, Robin M Hobbs, Leni Mannermaa, Markku Kallajoki, Edward K Chan, Pier Paolo Pandolfi, Jorma Toppari, Jukka Westermarck

Publikováno v: PLoS ONE, Vol 7, Iss 3, p e33209 (2012)

Protein phosphatase 2A (PP2A) is a critical regulator of protein serine/threonine phosphorylation. However, the physiological and developmental roles of different PP2A complexes are very poorly understood. Here, we show that a newly characterized PP2

Externí odkaz: https://doaj.org/article/a847f782e16f47129e4d8dd52c24a522

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Impact of U2AF1 mutations on circular RNA expression in myelodysplastic neoplasms

Autor: Eileen Wedge, Ulvi Ahmadov, Thomas B. Hansen, Zongliang Gao, Morten Tulstrup, Christophe Côme, Sridhar Nonavinkere Srivatsan, Tanzir Ahmed, Jakob S. Jespersen, Balthasar C. Schlotmann, Claudia Schöllkopf, Klas Raaschou-Jensen, Niels Ødum, Jørgen Kjems, Rasmus O. Bak, Matthew J. Walter, Kirsten Grønbæk, Lasse S. Kristensen

Publikováno v: Wedge, E, Ahmadov, U, Hansen, T B, Gao, Z, Tulstrup, M, Côme, C, Nonavinkere Srivatsan, S, Ahmed, T, Jespersen, J S, Schlotmann, B C, Schöllkopf, C, Raaschou-Jensen, K, Ødum, N, Kjems, J, Bak, R O, Walter, M J, Grønbæk, K & Kristensen, L S 2023, ' Impact of U2AF1 mutations on circular RNA expression in myelodysplastic neoplasms ', Leukemia, vol. 37, no. 5, pp. 1113-1125 . https://doi.org/10.1038/s41375-023-01866-4

Mutations in U2AF1 are relatively common in myelodysplastic neoplasms (MDS) and are associated with an inferior prognosis, but the molecular mechanisms underlying this are not fully elucidated. Circular RNAs (circRNAs) have been implicated in cancer,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d552d18cfb6225451b91d289182d9379
https://pure.au.dk/portal/da/publications/impact-of-u2af1-mutations-on-circular-rna-expression-in-myelodysplastic-neoplasms(3de8bf0a-a973-4385-b2c9-1ac1bb734ed6).html

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Data from Snail and Slug Play Distinct Roles during Breast Carcinoma Progression

Autor: Pierre Savagner, Charles Theillet, Karl Friedrich Becker, Pascal De Santa Barbara, Frédéric Bibeau, Fabrice Magnino, Christophe Côme

Purpose: Carcinoma progression is linked to a partially dedifferentiated epithelial cell phenotype. As previously suggested, this regulation could involve transcription factors, Snail and Slug, known to promote epithelial-mesenchymal transitions duri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::304825b01ea8cf40939d58b8207b55fe
https://doi.org/10.1158/1078-0432.c.6518287.v1

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