Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Christophe Boldron"'
Autor:
L. Millet, S. Bonnet-Lignon, N. Delesque-Touchard, A.M. Pflieger, F. Bono, Christophe Boldron, Jean-Marc Herbert, Pierre Savi, V. Salel, Lassalle Gilbert
Publikováno v:
Thrombosis Research. 134:693-703
P2Y 12 antagonism is a key therapeutic strategy in the management and prevention of arterial thrombosis. The objective of this study was to characterize the pharmacodynamic (PD) and pharmacokinetic (PK) properties of SAR216471, a novel P2Y 12 recepto
Autor:
Christophe Boldron, Guillem Aromí, Huub Kooijman, Anthony L. Spek, Jan Reedijk, Patrick Gamez
Publikováno v:
European Journal of Inorganic Chemistry. 2006:1940-1944
A new ligand, H5L3, has been synthesized featuring seven linearly arranged oxygen donors in form of two 1,3-diketone and three phenol groups. The X-ray structure of H5L3 unveils a rare case where one of the diketones is in the enolic form and the oth
Autor:
Stefaan Wera, Marguerite Pitié, Heinz Gornitzka, Ingrid Van der Auwera, Fred Van Leuven, Bernard Meunier, Céline Deraeve, Christophe Boldron
Publikováno v:
ChemBioChem
ChemBioChem, Wiley-VCH Verlag, 2005, 6, pp.1976-1980
ChemBioChem, Wiley-VCH Verlag, 2005, 6, pp.1976-1980
International audience
Autor:
Jan Reedijk, Patrick Gamez, Helen Stoeckli-Evans, Huub Kooijman, Guillem Aromí, Christophe Boldron, Joan Ribas, Olivier Roubeau, Anthony L. Spek
Publikováno v:
Dalton Trans.. :3586-3592
The synthesis of the new polynucleating ligand 1,3-bis-(3-oxo-3-(2-hydroxyphenyl)-propionyl)-benzene (H4L) is reported along with the preparation, structure and properties of its dinuclear complexes [Cu(2)(H(2)L)(2)(py)(2)](1), [Ni(2)(H(2)L)(2)(py)(4
Autor:
Laurence Millet, Angelina Besse, Stéphanie Tissandié, Gernot Zech, Marie-Francoise Bordes, Alain Badorc, Lassalle Gilbert, Valerie Fossey, Jean-Pascal Herault, Frédérique Dol, Christophe Boldron, Benjamin Gau, Christophe Briot, Nathalie Delesque, Anne-Marie Pflieger, Françoise Bono, Xavier Yvon, Marc Nazaré, Guillaume Barre, Tristan Rousseaux, Jean-Marc Herbert, Sandrine Bonnet-Lignon, Jerome Meneyrol, Pierre Savi
Publikováno v:
Journal of medicinal chemistry. 57(17)
In the search of a potential backup for clopidogrel, we have initiated a HTS campaign designed to identify novel reversible P2Y12 antagonists. Starting from a hit with low micromolar binding activity, we report here the main steps of the optimization
Publikováno v:
Synlett. 2001:1629-1631
Publikováno v:
ChemInform. 33
Autor:
Laure Vendier, Heinz Gornitzka, Christophe Boldron, Marguerite Pitié, Alexandrine Maraval, Bernard Meunier, Honoré Mazarguil, Céline Deraeve
Publikováno v:
Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, 2008, pp.682-696
Chemistry-A European Journal, Wiley-VCH Verlag, 2008, pp.682-696
Fourteen different ligands have been synthesized with two covalently linked 8-hydroxyquinoline motifs that favor metal complexation. These bis-chelators include different bridges at the C2 positions and different substituents to modulate their physic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d82a9c1c02bb8e4a176c4da522d088ba
https://hal.archives-ouvertes.fr/hal-00371845
https://hal.archives-ouvertes.fr/hal-00371845
Autor:
Bernard Meunier, Isabelle Roland, Karen Sliedregt-Bol, Marguerite Pitié, Robert Kiss, Christophe Boldron, Jan Reedijk, Paul de Hoog, Patrick Gamez
Publikováno v:
Journal of medicinal chemistry. 50(13)
The design and synthesis of new heterodinuclear DNA-targeting agents are described. The abilities of cisplatin and Cu(3-Clip-Phen) [Cu(1-(1,10-phenanthrolin-3-yloxy)-3-(1,10-phenanthrolin-8-yloxy)propan-2-amine)Cl2], an artificial DNA-cleaving agent,
Publikováno v:
ChemInform. 37
Mechanistic investigations on the oxidative coupling of 2,6-dimethylphenol have led to the development of a selective and efficient procedure to prepare 3,5,3',5'-tetramethyl-biphenyl-4,4'-diol, via a C-C coupling, mediated by a hypervalent form of i