Výsledky vyhledávání - "Christophe Boixel"

PCSK9 inhibition with alirocumab reduces lipoprotein(a) levels in nonhuman primates by lowering apolipoprotein(a) production rate

Autor: Ilya Khantalin, Stéphane Ramin-Mangata, Brice Nativel, Stéphanie Billon-Crossouard, Mikaël Croyal, Rose Hélène Blanchard, Etienne Guillot, Kévin Chemello, Michel Krempf, Valentin Blanchard, Gilles Lambert, Audrey Aguesse, Bruno Poirier, Philip Janiak, Elise F. Villard, Christophe Boixel, Jean-Christophe Le Bail, Aurélie Thedrez, Thi-Thu-Trang Tran

Publikováno v: Clinical Science
Clinical Science, Portland Press, 2018, 132 (10), pp.1075-1083. ⟨10.1042/CS20180040⟩

Therapeutic antibodies targeting proprotein convertase subtilisin kexin type 9 (PCSK9) (e.g. alirocumab) lower low-density lipoprotein cholesterol (LDL-C) and lipoprotein (a) [Lp(a)] levels in clinical trials. We recently showed that PCSK9 enhances a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::458694c8ac4928c889b310c06efa5781
https://doi.org/10.1042/cs20180040

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Alirocumab efficiently reduces LP(A) levels by lowering Apolipoprotein (A) [APO(A)] production rate in Non-Human primates (NHP)

Autor: Bruno Poirier, Rose-Hélène Blanchard, Thi-Thu-Trang Tran, Etienne Guillot, Jean-Chistophe Le Bail, Mikaël Croyal, Michel Krempf, Christophe Boixel, Gilles Lambert, Aurélie Thedrez, Elise F. Villard

Publikováno v: Atherosclerosis
85th Congress of the European-Atherosclerosis-Society (EAS)
85th Congress of the European-Atherosclerosis-Society (EAS), European Atherosclerosis Society. SWE., Apr 2017, Prague, Czech Republic. pp.1

International audience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::006af85719aef9f836bb623838cc5f44
https://hal.inrae.fr/hal-02737438

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Chronic angiotensin II stimulation in the heart produces an acquired long QT syndrome associated with IK1 potassium current downregulation

Autor: Christophe Boixel, Andrea A. Domenighetti, Hugues Abriel, Daniel Cefai, Thierry Pedrazzini

Publikováno v: Journal of Molecular and Cellular Cardiology. 42:63-70

Cardiac hypertrophy is an independent predictor of cardiovascular morbidity and mortality. It predisposes patients to heart failure, QT interval prolongation and ventricular arrhythmias. Angiotensin II (Ang II) exerts direct actions on cardiac tissue

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::586afb1e73e74aacd0748fccbc82c473
https://doi.org/10.1016/j.yjmcc.2006.09.019

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Cardiac Sodium Channel Na v 1.5 Is Regulated by a Multiprotein Complex Composed of Syntrophins and Dystrophin

Autor: Andrea A. Domenighetti, Patrick Ruchat, Hugues Abriel, Bruno Gavillet, Thierry Pedrazzini, Romina Behar, Jean-Sébastien Rougier, Hans A. Lehr, Christophe Boixel

Publikováno v: Circulation Research. 99:407-414

The cardiac sodium channel Na v 1.5 plays a key role in cardiac excitability and conduction. The purpose of this study was to elucidate the role of the PDZ domain-binding motif formed by the last three residues (Ser-Ile-Val) of the Na v 1.5 C-terminu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cf1d49267821c3ecbe2d436da4a8eda
https://doi.org/10.1161/01.res.0000237466.13252.5e

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Long-term amiodarone administration remodels expression of ion channel transcripts in the mouse heart

Autor: Chloé Bellocq, Arnaud Chambellan, Jean-Christophe Chevalier, Hugues Abriel, Céline Marionneau, Christophe Boixel, Sophie Demolombe, Khai Le Quang, Aziza El Harchi, Gilles Lande, Sabrina Le Bouter, Denis Escande, Toon A.B. van Veen, Jean J. Leger, Flavien Charpentier, Bruno Gavillet

Publikováno v: Circulation, 110(19), 3028-3035. LIPPINCOTT WILLIAMS & WILKINS

Background— The basis for the unique effectiveness of long-term amiodarone treatment on cardiac arrhythmias is incompletely understood. The present study investigated the pharmacogenomic profile of amiodarone on genes encoding ion-channel subunits.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e63fc48f5b3ef6aee13a98590bbb991a
https://research.rug.nl/en/publications/d259caa4-c454-460b-9fb7-9249a2eea13a

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Endothelium-independent conversion of angiotensin I by vascular smooth muscle cells

Autor: Maria E. Pueyo, Jean-Baptiste Michel, Christophe Boixel, Olivier Meilhac, Florence Coulet, Walter Gonzalez

Publikováno v: Cell and Tissue Research. 303:227-234

The conversion of angiotensin I (AT-I) to angiotensin II (AT-II) by angiotensin I-converting enzyme (ACE) is a key step in the action of angiotensins. ACE is constitutively expressed in endothelial cells, but can also be detected at low levels in smo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::158d0b6678cb8ecfd5c220193a22ed63
https://doi.org/10.1007/s004410000309

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