Zobrazeno 1 - 10
of 429
pro vyhledávání: '"Christophe Morisseau"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-20 (2024)
Abstract Oxylipins are a group of bioactive fatty acid metabolites generated via enzymatic oxygenation. They are notably involved in inflammation, pain, vascular tone, hemostasis, thrombosis, immunity, and coagulation. Oxylipins have become the focus
Externí odkaz:
https://doaj.org/article/c5206c6a1782433c8a8dc0ac63a80288
Autor:
Jeannes Angelia, Leah Duong, Faye Yun, Anesa Mesic, Cassandra Yuan, Daniel Carr, Siena Gunari, Paula K. Hudson, Christophe Morisseau, Bruce D. Hammock, Ram Kandasamy, Stevan Pecic
Publikováno v:
Heliyon, Vol 10, Iss 11, Pp e32262- (2024)
Simultaneous inhibition of soluble epoxide hydrolase (sEH) and fatty acid amide hydrolase (FAAH) with a single small molecule represents a novel therapeutic approach in treating inflammatory pain, since both targets are involved in pain and inflammat
Externí odkaz:
https://doaj.org/article/a9debe63a822457898455455adf78d0e
Autor:
Denis Babkov, Natalya Eliseeva, Kristina Adzhienko, Viktoria Bagmetova, Dmitry Danilov, Cynthia B. McReynolds, Christophe Morisseau, Bruce D. Hammock, Vladimir Burmistrov
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8841 (2024)
Inhibition of soluble epoxide hydrolase (sEH) is a promising therapeutic strategy for treating neuropathic pain. These inhibitors effectively reduce diabetic neuropathic pain and inflammation induced by Freund’s adjuvant which makes them a suitable
Externí odkaz:
https://doaj.org/article/063cf443125142fdb1fad3ed14a37aeb
Autor:
Daniel Carr, Christopher Chin, Tiffany Chacon, Monijeh Khoja Herawi, Michael Gonzalez, Ryan West, Christophe Morisseau, Bruce D. Hammock, Stevan Pecic, Ram Kandasamy
Publikováno v:
BBA Advances, Vol 6, Iss , Pp 100119- (2024)
Pain arising from trigeminal systems such as headache is common, debilitating, and current treatments (e.g., sumatriptan) are limited. New treatments that target novel mechanisms of action may be required to innovate both short- and long-term pain th
Externí odkaz:
https://doaj.org/article/40c250400278494e80f2caeb253914f4
Autor:
Vladimir V. Burmistrov, Christophe Morisseau, Dmitry V. Danilov, Boris P. Gladkikh, Vladimir S. D’yachenko, Nikolay A. Zefirov, Olga N. Zefirova, Gennady M. Butov, Bruce D. Hammock
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Series of 1,3-disubstituted ureas and diadamantyl disubstituted diureas with fluorinated and chlorinated adamantane residues were shown to inhibit human soluble epoxide hydrolase (sEH) with inhibition potency ranging from 40 pM to 9.2 nM. The measure
Externí odkaz:
https://doaj.org/article/a8df2f9e00794074bf2bbc27e9abe427
Autor:
Mona Peyman, Emma Barroso, Andreea L. Turcu, Francesc Estrany, Jr., Dáire Smith, Javier Jurado-Aguilar, Patricia Rada, Christophe Morisseau, Bruce D. Hammock, Ángela M. Valverde, Xavier Palomer, Carles Galdeano, Santiago Vázquez, Manuel Vázquez-Carrera
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115667- (2023)
Soluble epoxide hydrolase (sEH) is a drug target with the potential for therapeutic utility in the areas of inflammation, neurodegenerative disease, chronic pain, and diabetes, among others. Proteolysis-targeting chimeras (PROTACs) molecules offer ne
Externí odkaz:
https://doaj.org/article/5a58d1a50ea04ea4b20efc84ec133208
Autor:
Matthieu Leuillier, Thomas Duflot, Séverine Ménoret, Hind Messaoudi, Zoubir Djerada, Déborah Groussard, Raphaël G.P. Denis, Laurence Chevalier, Ahmed Karoui, Baptiste Panthu, Pierre-Alain Thiébaut, Isabelle Schmitz-Afonso, Séverine Nobis, Cynthia Campart, Tiphaine Henry, Camille Sautreuil, Serge H. Luquet, Olivia Beseme, Catherine Féliu, Hélène Peyret, Lionel Nicol, Jean-Paul Henry, Sylvanie Renet, Paul Mulder, Debin Wan, Laurent Tesson, Jean-Marie Heslan, Angéline Duché, Sébastien Jacques, Frédéric Ziegler, Valéry Brunel, Gilles J.P. Rautureau, Christelle Monteil, Jean-Luc do Rego, Jean-Claude do Rego, Carlos Afonso, Bruce Hammock, Anne-Marie Madec, Florence Pinet, Vincent Richard, Ignacio Anegon, Christophe Guignabert, Christophe Morisseau, Jérémy Bellien
Publikováno v:
Journal of Advanced Research, Vol 43, Iss , Pp 163-174 (2023)
Introduction: Although the physiological role of the C-terminal hydrolase domain of the soluble epoxide hydrolase (sEH-H) is well investigated, the function of its N-terminal phosphatase activity (sEH-P) remains unknown. Objectives: This study aimed
Externí odkaz:
https://doaj.org/article/ae3d2c7efa674a65a28617072bd9a0df
Autor:
Janney Z. Wang, Paus Paulus, Yihe Niu, Ling Zhu, Christophe Morisseau, Tristan Rawling, Michael Murray, Bruce D. Hammock, Fanfan Zhou
Publikováno v:
Biomedicines, Vol 12, Iss 2, p 462 (2024)
Autophagy is a form of programmed cell degradation that enables the maintenance of homeostasis in response to extracellular stress stimuli. Autophagy is primarily activated by starvation and mediates the degradation, removal, or recycling of cell cyt
Externí odkaz:
https://doaj.org/article/c5e30f1beed44243ba0bb71a661541f2
Autor:
Weicang Wang, Yuxin Wang, Jun Yang, Karen M. Wagner, Sung Hee Hwang, Jeff Cheng, Nalin Singh, Patricia Edwards, Christophe Morisseau, Guodong Zhang, Dipak Panigrahy, Bruce D. Hammock
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 249, Iss , Pp 114417- (2023)
Aflatoxin B1 (AFB1) contamination in food and feed leads to severe global health problems. Acting as the frontier immunological barrier, the intestinal mucosa is constantly challenged by exposure to foodborne toxins such as AFB1 via contaminated diet
Externí odkaz:
https://doaj.org/article/b86630bc862b4620bcd224329a2856c0
Autor:
Qiyi He, Mark R. McCoy, Meng Qi, Christophe Morisseau, Huiyi Yang, Chengpeng Xu, Rachel Shey, Michael C. Goodman, Suqing Zhao, Bruce D. Hammock
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 19, p 14698 (2023)
A microsomal epoxide hydrolase (mEH) metabolizes in vivo in both xenobiotic and endogenous epoxides associated with signaling function. Findings in patients suggest that mEH might be a biomarker for several diseases, including metastatic cancer and v
Externí odkaz:
https://doaj.org/article/176413cef79d4c5586cf704d4e4311bc