ZAKα/P38 kinase signaling pathway regulates hematopoiesis by activating the NLRP1 inflammasome

Autor: Lola Rodríguez‐Ruiz, Juan M Lozano‐Gil, Elena Naranjo‐Sánchez, Elena Martínez‐Balsalobre, Alicia Martínez‐López, Christophe Lachaud, Miguel Blanquer, Toan K Phung, Diana García‐Moreno, María L Cayuela, Sylwia D Tyrkalska, Ana B Pérez‐Oliva, Victoriano Mulero

Publikováno v: EMBO Molecular Medicine, Vol 15, Iss 10, Pp n/a-n/a (2023)

Abstract Chronic inflammatory diseases are associated with hematopoietic lineage bias, including neutrophilia and anemia. We have recently identified that the canonical inflammasome mediates the cleavage of the master erythroid transcription factor G

Externí odkaz: https://doaj.org/article/b205befa4d104117853060fc54fa807b

Improved genome editing in human cell lines using the CRISPR method.

Autor: Ivan M Munoz, Piotr Szyniarowski, Rachel Toth, John Rouse, Christophe Lachaud

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e109752 (2014)

The Cas9/CRISPR system has become a popular choice for genome editing. In this system, binding of a single guide (sg) RNA to a cognate genomic sequence enables the Cas9 nuclease to induce a double-strand break at that locus. This break is next repair

Externí odkaz: https://doaj.org/article/2491b77152034ba5aaaedd6f6c00bc82

Single Cell Analyses Reveal a Non-Canonical EZH2 Activity As a Main Driver of Retinoic Acid Resistance in PLZF/Rara Leukemia

Autor: Motohiko Oshima, Lia N’guyen, Estelle Duprez, Nadine Carbuccia, Shuhei Koide, Mathilde Poplineau, Léonard Hérault, Christophe Lachaud, Adrien Mazuel, Julien Vernerey, Atsushi Iwama, Nadine Platet, Daniel Birnbaum, Wakako Kuribayashi

Publikováno v: Blood. 138:2205-2205

Resistance to treatment is due to the heterogeneity of the tumor which contains a subset of cancer cells that escape treatment and are responsible for the relapse. Acute Promyelocytic Leukemia (APL), the M3 subtype of AML, is a good model to illustra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bcefa8dc1437ba110c040ed66df24c50
https://doi.org/10.1182/blood-2021-146777

UFMylation of MRE11 is essential for maintenance of telomere length and hematopoietic stem cell survival

Autor: Luc Camoin, Gilles Audoly, Stéphane Audebert, Perez Oliva Ab, Azzoni, Lara Lee, Geli, Rahmouni D, Dmitri Churikov, Mulero, María L. Cayuela, Joshua Peter, Elena Martínez-Balsalobre, Yogesh Kulathu, Christophe Lachaud

Genetic studies using knockout mouse models provide strong evidence for the essential role of the ubiquitin-like protein UFM1 for hematopoiesis, especially erythroid development, yet its biological roles in this process are largely unknown. Here we h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba271d902bc1985d20b3d553c8566491

Inflammasome Regulates Hematopoiesis through Cleavage of the Master Erythroid Transcription Factor GATA1

Autor: Sylwia D. Tyrkalska, Irene Pardo-Sánchez, Francisco J. Martínez-Navarro, Nouraiz Ahmed, Ana B. Pérez-Oliva, Francisco J. Martínez-Morcillo, Avik Choudhuri, Victoriano Mulero, Francisca Alcaraz-Pérez, Christophe Lachaud, Leonard I. Zon, Lola Rodríguez-Ruiz, Marlies P. Rossmann, Azucena López-Muñoz, Timm Schroeder, María L. Cayuela, Sergio Candel, Diana García-Moreno

Publikováno v: Immunity
Immunity, 2019, Epub ahead of print. ⟨10.1016/j.immuni.2019.05.005⟩
Immunity, Elsevier, 2019, Epub ahead of print. ⟨10.1016/j.immuni.2019.05.005⟩

International audience; Chronic inflammatory diseases are associated with altered hematopoiesis that could result in neutrophilia and anemia. Here we report that genetic or chemical manipulation of different inflammasome components altered the differ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da6de17a07081881e80ebacb6d35c350
https://doi.org/10.1016/j.immuni.2019.05.005