Zobrazeno 1 - 10
of 175
pro vyhledávání: '"Christophe, Hirtz"'
Autor:
Sylvain Lehmann, Susanna Schraen-Maschke, Luc Buée, Jean-Sébastien Vidal, Constance Delaby, Christophe Hirtz, Frédéric Blanc, Claire Paquet, Bernadette Allinquant, Stéphanie Bombois, Audrey Gabelle, Olivier Hanon, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-14 (2024)
Abstract Background Current AT(N) stratification for Alzheimer’s disease (AD) accounts for complex combinations of amyloid (A), tau proteinopathy (T) and neurodegeneration (N) signatures. Understanding the transition between these different stages
Externí odkaz:
https://doaj.org/article/c860af25033746cb82e1ae7cdbcb2d80
Autor:
Léna Meneux, Nadège Feret, Sarah Pernot, Mélissa Girard, Solange Sarkis, Alicia Caballero Megido, Melanie Quiles, Agnès Müller, Laura Fichter, Jerome Vialaret, Christophe Hirtz, Cecile Delettre, Frederic Michon
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Mitochondrial dysfunctions are detrimental to organ metabolism. The cornea, transparent outmost layer of the eye, is prone to environmental aggressions, such as UV light, and therefore dependent on adequate mitochondrial function. While seve
Externí odkaz:
https://doaj.org/article/57bc91c090104b20816d79cafe156427
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-4 (2023)
Abstract The glymphatic system is a crucial component in preserving brain homeostasis by facilitating waste clearance from the central nervous system (CNS). Aquaporin-4 (AQP4) water channels facilitate the continuous interchange between cerebrospinal
Externí odkaz:
https://doaj.org/article/be23024977454dd6abf5ba2f1325f4fd
Autor:
Thomas S. Owens, Christopher J. Marley, Thomas A. Calverley, Benjamin S. Stacey, Lewis Fall, Hayato Tsukamoto, Angelo Iannetelli, Teresa Filipponi, Bruce Davies, Gareth L. Jones, Christophe Hirtz, Sylvain Lehmann, Edouard Tuaillon, Nicola Marchi, Damian M. Bailey
Publikováno v:
Experimental Physiology, Vol 108, Iss 8, Pp 1029-1046 (2023)
Abstract Following retirement from sport, the chronic consequences of prior‐recurrent contact are evident and retired rugby union players may be especially prone to accelerated cognitive decline. The present study sought to integrate molecular, cer
Externí odkaz:
https://doaj.org/article/288736faaa72449ab5c3d59491b21926
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 10, Iss 1, Pp n/a-n/a (2024)
Abstract Introduction The exclusion of affected populations from Alzheimer's disease (AD) clinical research limits our understanding of disease heterogeneity and its impact on clinical care. While micro sampling with dried plasma spots (DPS) can prom
Externí odkaz:
https://doaj.org/article/8193eef4756e436ab0a34186fd9fab24
Autor:
Christophe Hirtz, Germain U. Busto, Karim Bennys, Jana Kindermans, Sophie Navucet, Laurent Tiers, Simone Lista, Jérôme Vialaret, Laure-Anne Gutierrez, Yves Dauvilliers, Claudine Berr, Sylvain Lehmann, Audrey Gabelle
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-12 (2023)
Abstract Background Alzheimer’s disease (AD) is a complex neurodegenerative disorder with β-amyloid pathology as a key underlying process. The relevance of cerebrospinal fluid (CSF) and brain imaging biomarkers is validated in clinical practice fo
Externí odkaz:
https://doaj.org/article/6fc3f7aac5d146e7b75806a0e6a82b48
Autor:
Pablo Mohaupt, Marie-Laure Pons, Jérôme Vialaret, Constance Delaby, Christophe Hirtz, Sylvain Lehmann
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-4 (2022)
Abstract Synaptic degeneration is an early event closely associated with the course of Alzheimer’s disease (AD). The identification of synaptic blood biomarkers is, therefore, of great interest and clinical relevance. The levels of most synaptic pr
Externí odkaz:
https://doaj.org/article/fa4002ff7cac4b50b7dfddaf9d9b06b7
Autor:
Christophe Hirtz, Atef Mahmoud Mannaa, Estelle Moulis, Olivier Pible, Robin O’Flynn, Jean Armengaud, Virginie Jouffret, Camille Lemaistre, Gabriel Dominici, Alex Yahiaoui Martinez, Catherine Dunyach-Remy, Laurent Tiers, Jean-Philippe Lavigne, Paul Tramini, Marie-christine Goldsmith, Sylvain Lehmann, Dominique Deville de Périère, Jerome Vialaret
Publikováno v:
ACS Omega, Vol 7, Iss 10, Pp 8258-8267 (2022)
Externí odkaz:
https://doaj.org/article/ddeb21a6eecb4ba09fd856de7d256f26
Autor:
Pablo Mohaupt, Xavier Roucou, Constance Delaby, Jérôme Vialaret, Sylvain Lehmann, Christophe Hirtz
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Translation involves the biosynthesis of a protein sequence following the decoding of the genetic information embedded in a messenger RNA (mRNA). Typically, the eukaryotic mRNA was considered to be inherently monocistronic, but this paradigm is not i
Externí odkaz:
https://doaj.org/article/9cc3e8bbf7294c709577a5da0febfed6
Autor:
Sébastien Relier, Julie Ripoll, Hélène Guillorit, Amandine Amalric, Cyrinne Achour, Florence Boissière, Jérôme Vialaret, Aurore Attina, Françoise Debart, Armelle Choquet, Françoise Macari, Virginie Marchand, Yuri Motorin, Emmanuelle Samalin, Jean-Jacques Vasseur, Julie Pannequin, Francesca Aguilo, Evelyne Lopez-Crapez, Christophe Hirtz, Eric Rivals, Amandine Bastide, Alexandre David
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The demethylase FTO was shown to remove on N6-methyladenosine (m6A) and N6, 2’-O-dimethyladenosine (m6Am) modifications on RNAs. Here the authors show that FTO impedes cancer stem cell-like abilities in colorectal cancer cells through its m6Am deme
Externí odkaz:
https://doaj.org/article/9446244d632a4b05a389d98461a70dd7