Neonatal brain injury unravels transcriptional and signaling changes underlying the reactivation of cortical progenitors

Autor: Louis Foucault, Timothy Capeliez, Diane Angonin, Celia Lentini, Laurent Bezin, Christophe Heinrich, Carlos Parras, Vanessa Donega, Guillaume Marcy, Olivier Raineteau

Publikováno v: Cell Reports, Vol 43, Iss 2, Pp 113734- (2024)

Summary: Germinal activity persists throughout life within the ventricular-subventricular zone (V-SVZ) of the postnatal forebrain due to the presence of neural stem cells (NSCs). Accumulating evidence points to a recruitment for these cells following

Externí odkaz: https://doaj.org/article/94e2692e92984ecd8480dd4def4a48f9

Evidence of Progenitor Cell Lineage Rerouting in the Adult Mouse Hippocampus After Status Epilepticus

Autor: Daniela M. S. Moura, Juliana Alves Brandão, Celia Lentini, Christophe Heinrich, Claudio M. Queiroz, Marcos R. Costa

Publikováno v: Frontiers in Neuroscience, Vol 14 (2020)

Cell lineage in the adult hippocampus comprises multipotent and neuron-committed progenitors. In the present work, we fate-mapped neuronal progenitors using Dcx-CreERT2 and CAG-CAT-EGFP double-transgenic mice (cDCX/EGFP). We show that 3 days after ta

Externí odkaz: https://doaj.org/article/5309f1837fad4367b405a9d76e36dcb4

Single-cell analysis of the postnatal dorsal V-SVZ reveals a role for Bmpr1a signaling in silencing pallial germinal activity

Autor: Guillaume Marcy, Louis Foucault, Elodie Babina, Timothy Capeliez, Emeric Texeraud, Stefan Zweifel, Christophe Heinrich, Hector Hernandez-Vargas, Carlos Parras, Denis Jabaudon, Olivier Raineteau

Publikováno v: Science Advances. 9

The ventricular-subventricular zone (V-SVZ) is the largest neurogenic region of the postnatal forebrain, containing neural stem cells (NSCs) that emerge from both the embryonic pallium and subpallium. Despite of this dual origin, glutamatergic neurog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2bc6a8197d6cc206f95dede63cf33aea
https://doi.org/10.1126/sciadv.abq7553

Single cell analysis of the dorsal V-SVZ reveals differential quiescence of postnatal pallial and subpallial neural stem cells driven by TGFbeta/BMP-signalling

Autor: Guillaume Marcy, Louis Foucault, Elodie Babina, Emeric Texeraud, Stefan Zweifel, Christophe Heinrich, Hector Hernandez-Vargas, Carlos Parras, Denis Jabaudon, Olivier Raineteau

The ventricular-subventricular zone (V-SVZ) is the largest neurogenic region of the postnatal forebrain, containing neural stem cells (NSCs) that emerge from both the embryonic pallium and subpallium. Despite of this dual origin, glutamatergic neurog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fecacf59f87a4cae1a09ae81635a2213
https://doi.org/10.1101/2022.05.20.492790

Reprogramming reactive glia into interneurons reduces chronic seizure activity in a mouse model of mesial temporal lobe epilepsy

Autor: Karl-Klaus Conzelmann, Nicolás Marichal, Charlotte Verrier, Olivier Raineteau, Rory Vignoles, Sylvie Rival-Gervier, Antoine Depaulis, Louis Foucault, Christophe Heinrich, Marie-Madeleine Trottmann, Marie d’Orange, Célia Lentini, Benedikt Berninger, Céline Massera

Publikováno v: Cell Stem Cell
Cell Stem Cell, Cambridge, MA : Cell Press, 2021, ⟨10.1016/j.stem.2021.09.002⟩
Cell Stem Cell, 2021, 28 (12), pp.2104-2121.e10. ⟨10.1016/j.stem.2021.09.002⟩

Summary Reprogramming brain-resident glial cells into clinically relevant induced neurons (iNs) is an emerging strategy toward replacing lost neurons and restoring lost brain functions. A fundamental question is now whether iNs can promote functional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::374632c498c935e8a94ca22d13776442
https://hal.inrae.fr/hal-03361443