Epigenetic rewriting at centromeric DNA repeats leads to increased chromatin accessibility and chromosomal instability

Autor: Sheldon Decombe, François Loll, Laura Caccianini, Kévin Affannoukoué, Ignacio Izeddin, Julien Mozziconacci, Christophe Escudé, Judith Lopes

Publikováno v: Epigenetics & Chromatin, Vol 14, Iss 1, Pp 1-17 (2021)

Abstract Background Centromeric regions of human chromosomes contain large numbers of tandemly repeated α-satellite sequences. These sequences are covered with constitutive heterochromatin which is enriched in trimethylation of histone H3 on lysine

Externí odkaz: https://doaj.org/article/9eba68552651479a8571190058331ef0

Interaction of fluorescently labeled pyrrole-imidazole polyamide probes with fixed and living murine and human cells

Autor: François Loll, Karine Nozeret, Christophe Escudé, Gildas Mouta Cardoso, Alexandre S. Boutorine

Publikováno v: Biochimie
Biochimie, Elsevier, 2018, ⟨10.1016/j.biochi.2018.03.008⟩

International audience; Pericentromeric heterochromatin plays important roles in controlling gene expression and cellular differentiation. Fluorescent pyrrole-imidazole polyamides targeting murine pericentromeric DNA (major satellites) can be used fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af871a6e6e37016fb70b5a886f5a25a2
https://doi.org/10.1016/j.biochi.2018.03.008

Diversity and distribution of alpha satellite DNA in the genome of an Old World monkey: Cercopithecus solatus

Autor: Loïc Ponger, Michèle Gerbault-Seureau, Florence Richard, Christophe Escudé, Lauriane Cacheux

Publikováno v: BMC Genomics
BMC Genomics, BioMed Central, 2016, 17, pp.916. ⟨10.1186/s12864-016-3246-5⟩
BMC Genomics, 2016, 17, pp.916. ⟨10.1186/s12864-016-3246-5⟩

Background Alpha satellite is the major repeated DNA element of primate centromeres. Evolution of these tandemly repeated sequences has led to the existence of numerous families of monomers exhibiting specific organizational patterns. The limited amo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77f1a381e0fa33ea49f9f30fd347a1ee
https://hal.sorbonne-universite.fr/hal-01417886

Multiple topological labeling for imaging single plasmids

Autor: Thibaut Roulon, Christophe Escudé, Eric Le Cam, Sébastien Lyonnais

Publikováno v: Analytical Biochemistry
Analytical Biochemistry, 2007, 362 (1), pp.55-62. ⟨10.1016/j.ab.2006.12.028⟩
Analytical Biochemistry, Elsevier Masson, 2007, 362 (1), pp.55-62. ⟨10.1016/j.ab.2006.12.028⟩

Sequence-specific labeling methods for double-stranded DNA are required for mapping protein binding sites or specific DNA structures on circular DNA molecules by high-resolution imaging techniques such as electron and atomic force microscopies. Site-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d95ae91e7d751002cd4ad280d0032d
https://doi.org/10.1016/j.ab.2006.12.028

Ligand-Mediated Transcription Elongation Control Using Triplex-Based Padlock Oligonucleotides

Autor: Thibaut Roulon, Christophe Escudé, Mahajoub Bello-Roufaï

Publikováno v: Chemistry & Biology. 11(4):509-516

Triplex-forming oligonucleotides (TFOs) provide useful tools for the artificial regulation of gene expression at the transcriptional level. They can become topologically linked to their DNA target upon circularization, thereby forming very stable tri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::388e44450ada0e06503d3e9a7faf6f16