Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Christoph von Ballmoos"'
Autor:
Lea Gigon, Philipp Müller, Beat Haenni, Ioan Iacovache, Maruša Barbo, Gordana Gosheva, Shida Yousefi, Alice Soragni, Christoph von Ballmoos, Benoît Zuber, Hans-Uwe Simon
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114084- (2024)
Summary: Eosinophils play a crucial role in host defense while also contributing to immunopathology through the release of inflammatory mediators. Characterized by distinctive cytoplasmic granules, eosinophils securely store and rapidly release vario
Externí odkaz:
https://doaj.org/article/d182e05a08354491ada376f038ee4c1c
Autor:
Iven Winkelmann, Povilas Uzdavinys, Ian M. Kenney, Joseph Brock, Pascal F. Meier, Lina-Marie Wagner, Florian Gabriel, Sukkyeong Jung, Rei Matsuoka, Christoph von Ballmoos, Oliver Beckstein, David Drew
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
By determining the crystal structure of the Na + /H + antiporter NhaA at active pH, the authors show how substrate accessibility to the ion-binding site can be controlled by pH sensitive switch located on the cytoplasmic surface.
Externí odkaz:
https://doaj.org/article/d75c94092f084db7b84a655abf5cc842
Autor:
Tin Manh Ho, Stephan Berger, Philipp Müller, Céline Simonin, Jean-Louis Reymond, Christoph von Ballmoos, Daniel G. Fuster
Publikováno v:
CHIMIA, Vol 76, Iss 12 (2022)
NHA2, also known as SLC9B2, is an orphan intracellular Na+/H+ exchanger (NHE) that has been associated with arterial hypertension and diabetes mellitus in humans. The objective of this NCCR TransCure project was to define the physiological and molecu
Externí odkaz:
https://doaj.org/article/fd6fcc47e6ba4df08457732160774ec5
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Membrane bound nicotinamide nucleotide transhydrogenase (TH) catalyses the hydride transfer from NADH to NADP+. Under physiological conditions, this reaction is endergonic and must be energized by the pmf, coupled to transmembrane proton tra
Externí odkaz:
https://doaj.org/article/1c84d62ee717445297ab913316242a58
Autor:
Franziska Nuber, Johannes Schimpf, Jean-Paul di Rago, Déborah Tribouillard-Tanvier, Vincent Procaccio, Marie-Laure Martin-Negrier, Aurélien Trimouille, Olivier Biner, Christoph von Ballmoos, Thorsten Friedrich
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract NADH:ubiquinone oxidoreductase (respiratory complex I) plays a major role in energy metabolism by coupling electron transfer from NADH to quinone with proton translocation across the membrane. Complex I deficiencies were found to be the most
Externí odkaz:
https://doaj.org/article/26652c8a0a244e3ead826a846ee6b58d
Autor:
Johannes Sjöholm, Jan Bergstrand, Tobias Nilsson, Radek Šachl, Christoph von Ballmoos, Jerker Widengren, Peter Brzezinski
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract We have investigated the effect of lipid composition on interactions between cytochrome bo 3 and ATP-synthase, and the ATP-synthesis activity driven by proton pumping. The two proteins were labeled by fluorescent probes and co-reconstituted
Externí odkaz:
https://doaj.org/article/854e6b1f99234dfd8912dff107157590
Publikováno v:
CHIMIA, Vol 72, Iss 5 (2018)
Our group at the University of Bern uses biochemical and biophysical techniques to unravel details of the molecular mechanism of membrane proteins. Of special interest are the large multi-subunit complexes of the universally conserved respiratory cha
Externí odkaz:
https://doaj.org/article/2dec2f71cc74426f8dd9cdb7197e32f5
Autor:
Olivier Biner, Christian Trachsel, Aline Moser, Lukas Kopp, Nicolas Langenegger, Urs Kämpfer, Christoph von Ballmoos, Wolfgang Nentwig, Stefan Schürch, Johann Schaller, Lucia Kuhn-Nentwig
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0143963 (2015)
Hyaluronidases are important venom components acting as spreading factor of toxic compounds. In several studies this spreading effect was tested on vertebrate tissue. However, data about the spreading activity on invertebrates, the main prey organism
Externí odkaz:
https://doaj.org/article/c066687fe40c40b78f45fe856624e9e9
Autor:
Abbas Abou-Hamdan, Roman Mahler, Philipp Grossenbacher, Olivier Biner, Dan Sjöstrand, Martin Lochner, Martin Högbom, Christoph von Ballmoos
Publikováno v:
Abou Hamdan, Abbas; Mahler, Roman; Grossenbacher, Philipp; Biner, Olivier; Sjöstrand, Dan; Lochner, Martin; Högbom, Martin; von Ballmoos, Christoph (2022). Functional design of bacterial superoxide:quinone oxidoreductase. Biochimica et biophysica acta. Bioenergetics, 1863(7), p. 148583. Elsevier 10.1016/j.bbabio.2022.148583
The superoxide anion - molecular oxygen reduced by a single electron - is produced in large amounts by enzymatic and adventitious reactions and can perform a range of cellular functions, including bacterial warfare and iron uptake, signalling and hos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f45e63f8c88e8af7797b3f817673776c
https://boris.unibe.ch/170499/9/1-s2.0-S0005272822000524-main.pdf
https://boris.unibe.ch/170499/9/1-s2.0-S0005272822000524-main.pdf
Publikováno v:
Amati, Andrea Marco; Graf, Simone; Deutschmann, Sabina; Dolder, Nicolas; von Ballmoos, Christoph (2020). Current problems and future avenues in proteoliposome research. Biochemical Society transactions, 48(4), pp. 1473-1492. Portland Press 10.1042/BST20190966
Membrane proteins (MPs) are the gatekeepers between different biological compartments separated by lipid bilayers. Being receptors, channels, transporters, or primary pumps, they fulfill a wide variety of cellular functions and their importance is re