Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Christoph Wigge"'
Publikováno v:
Drug discovery today. Technologies. 38
Since the early 2010s, cryo-electron microscopy (cryo-EM) has evolved to a mainstream structural biology method in what has been dubbed the “resolution revolution”. Pharma companies also began to use cryo-EM in drug discovery, evidenced by a grow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37a18430cb7ae041c58e242ef46956c3
https://pubmed.ncbi.nlm.nih.gov/34895645
https://pubmed.ncbi.nlm.nih.gov/34895645
Autor:
Stephen D. Carter, Wen Li, Sandra A. Murray, Deborah Fass, Jenny I. Aguilar, José María Carazo, Meir Aridor, Michael J. Calderon, Sruti Shiva, Leanna Eisenman, Zachary J. Farino, Elana S. Levy, Stephanie E. Siegmund, William J. Rice, Allen Volchuk, Jyotsna Pilli, Edward Yi, Robin Freyberg, Robert A. Grassucci, Christoph Wigge, Tamas Balla, Grant J. Jensen, Zachary Freyberg, Nili L. Greenberg, Roberto Melero, Kenneth N. Fish, Travis J Morgenstern, Cheri M. Hampton, Estela Area-Gomez, Maïté Courel, Joshua G. Pemberton, Sharon G. Wolf, Callen T. Wallace, William G. Mitchell, Joachim Frank, Emily W. George, Simon C. Watkins, Ngoc-Han Tran, Zachary P. Wills, Robert Langlois, Despoina Aslanoglou, Francesca Bartolini, Peter Walter, Jonathan A. Javitch
Publikováno v:
Science advances, vol 6, iss 14
Science Advances
Digital.CSIC. Repositorio Institucional del CSIC
instname
Science Advances
Digital.CSIC. Repositorio Institucional del CSIC
instname
The endoplasmic reticulum (ER) is a highly dynamic network of membranes. Here, we combine live-cell microscopy with in situ cryo-electron tomography to directly visualize ER dynamics in several secretory cell types including pancreatic β-cells and n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad6c12563619c7bb859ab52fcc61cc9e
https://escholarship.org/uc/item/54c9n3tb
https://escholarship.org/uc/item/54c9n3tb
Autor:
William J. Rice, Clinton S. Potter, Hui Wei, Christoph Wigge, Bridget Carragher, David Melnekoff, Ivan Razinkov, Zhening Zhang, Venkata P. Dandey
Publikováno v:
Journal of Structural Biology. 195:190-198
Almost every aspect of cryo electron microscopy (cryoEM) has been automated over the last few decades. One of the challenges that remains to be addressed is the robust and reliable preparation of vitrified specimens of suitable ice thickness. We pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea8419991d0263a1f0a9c4705b1dcd0
https://doi.org/10.1016/j.jsb.2016.06.001
https://doi.org/10.1016/j.jsb.2016.06.001
Autor:
Masato Akutsu, Anja Habermann, Krishnaraj Rajalingam, Kieran McGourty, Dirk Bumann, David G. McEwan, Anja Kirchof, Fraser P. Coxon, Miep H. Helfrich, Benjamin Richter, Mirita Franz-Wachtel, Christoph Wigge, David W. Holden, Ivan Dikic, Paul R. Odgren, Bram Perdu, Philipp Wild, Boris Macek, Achilleas S. Frangakis, Beatrice Claudi, Wim Van Hul, Hesso Farhan
Publikováno v:
Cell Host & Microbe
Cell host & microbe
Cell host & microbe
The host endolysosomal compartment is often manipulated by intracellular bacterial pathogens. Salmonella (Salmonella enterica serovar Typhimurium) secrete numerous effector proteins, including SifA, through a specialized type III secretion system to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a6aa90b911a52fae6a6bf60a66b498
Autor:
Bridget Carragher, Qingbo Liu, William J. Rice, Clinton S. Potter, Christina Guzzo, Michael A. Dolan, Peter D. Kwong, Huiyi Miao, Priyamvada Acharya, Deepali Gururani, Tongqing Zhou, Tatsiana Bylund, Paolo Lusso, Jacky Lu, Peng Zhang, Aliaksandr Druz, Christoph Wigge, Gwo-Yu Chuang, Alice Kwon
Cryo-EM analyses of the initial contact of the HIV-1 Env trimer with the CD4 receptor reveal that CD4 interacts with two gp120 protomers; these quaternary contacts are important for viral infectivity. Binding of the gp120 envelope (Env) glycoprotein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86519905dfdfa3ead50bf9241da8d123
https://europepmc.org/articles/PMC5798227/
https://europepmc.org/articles/PMC5798227/
Autor:
Christoph Wigge, Victor-Valentin Hodirnau, Ulrike Endesfelder, Anja Seybert, Sebastian Malkusch, Margot P. Scheffer, Erin M. Schuman, Mike Heilemann, Michael Kunz, Mario Perkovic, Zhou Yu, Achilleas S. Frangakis, Stefanie Bunse
Publikováno v:
J. Struct. Biol.
Correlative microscopy incorporates the specificity of fluorescent protein labeling into high-resolution electron micrographs. Several approaches exist for correlative microscopy, most of which have used the green fluorescent protein (GFP) as the lab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4da2d801908674ef90f4880392fd699
Autor:
Alexander W. Mühleip, Christoph Wigge, Achilleas S. Frangakis, Karen M. Davies, Friederike Joos, Werner Kühlbrandt
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 113, iss 30
Mühleip, AW; Joos, F; Wigge, C; Frangakis, AS; Kühlbrandt, W; & Davies, KM. (2016). Helical arrays of U-shaped ATP synthase dimers form tubular cristae in ciliate mitochondria. Proceedings of the National Academy of Sciences of the United States of America, 113(30), 8442-8447. doi: 10.1073/pnas.1525430113. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/6d68574p
Mühleip, AW; Joos, F; Wigge, C; Frangakis, AS; Kühlbrandt, W; & Davies, KM. (2016). Helical arrays of U-shaped ATP synthase dimers form tubular cristae in ciliate mitochondria. Proceedings of the National Academy of Sciences of the United States of America, 113(30), 8442-8447. doi: 10.1073/pnas.1525430113. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/6d68574p
F1Fo-ATP synthases are universal energy-converting membrane protein complexes that synthesize ATP from ADP and inorganic phosphate. In mitochondria of yeast and mammals, the ATP synthase forms V-shaped dimers, which assemble into rows along the highl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8646cc1ca1aa1d536e7f3d7a1317023e
https://escholarship.org/uc/item/6d68574p
https://escholarship.org/uc/item/6d68574p
Autor:
Achilleas S. Frangakis, Melanie Boerries, Thomas Benzing, Alessia Fornoni, Anja Habermann, Florian Grahammer, Martin Klose, Jaakko Patrakka, Christoph Wigge, Andreas Bregenzer, Simon Schneider, Christoph Schell, Markus M. Rinschen, Dennis Rubbenstroth, Oliver Kretz, Linus A. Völker, Dontscho Kerjaschki, Sebastian J. Arnold, Tobias B. Huber, Ricarda Bräuniger, Julia Kind, Jeffrey H. Miner, Gerd Walz
Publikováno v:
Grahammer, F, Wigge, C, Schell, C, Kretz, O, Patrakka, J, Schneider, S, Klose, M, Kind, J, Arnold, S J, Habermann, A, Bräuniger, R, Rinschen, M M, Völker, L, Bregenzer, A, Rubbenstroth, D, Boerries, M, Kerjaschki, D, Miner, J H, Walz, G, Benzing, T, Fornoni, A, Frangakis, A S & Huber, T B 2016, ' A flexible, multilayered protein scaffold maintains the slit in between glomerular podocytes ', JCI Insight, vol. 1, no. 9, e86177 . https://doi.org/10.1172/jci.insight.86177
Vertebrate life critically depends on renal filtration and excretion of low molecular weight waste products. This process is controlled by a specialized cell-cell contact between podocyte foot processes: the slit diaphragm (SD). Using a comprehensive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f39de504623189a21439f9bfbb813e53
https://pure.au.dk/portal/da/publications/a-flexible-multilayered-protein-scaffold-maintains-the-slit-in-between-glomerular-podocytes(bb687542-92f3-4782-b8a6-dbfafe0eff45).html
https://pure.au.dk/portal/da/publications/a-flexible-multilayered-protein-scaffold-maintains-the-slit-in-between-glomerular-podocytes(bb687542-92f3-4782-b8a6-dbfafe0eff45).html
Autor:
Walther Mothes, Priyamvada Acharya, Aliaksandr Druz, Christoph Wigge, Tongqing Zhou, Qingbo Liu, Maolin Lu, Jason Gorman, Tatsiana Bylund, Paolo Lusso, Xiaochu Ma, William J. Rice, Clinton S. Potter, Peter D. Kwong, Bridget Carragher, Gwo-Yu Chuang, Edward T. Eng, Venkat Dandey, Hui Geng
Publikováno v:
Microscopy and Microanalysis. 23:1190-1191
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afc50852a67bc38ee3031459145872dd
https://doi.org/10.1017/s1431927617006614
https://doi.org/10.1017/s1431927617006614
Autor:
Manoranjan Sahu, Otmar Schmid, Alexander Wenk, Pratim Biswas, Izabela Cydzik, Neil Gibson, Christoph Wigge, Knut Deppert, Marianne Geiser, Manuela Semmler-Behnke, Wolfgang G. Kreyling, Maria E. Messing
Publikováno v:
J Nanoparticle Research
Journal of Nanoparticle Research
Kreyling, Wolfgang G.; Biswas, Pratim; Messing, Maria E.; Gibson, Neil; Geiser, Marianne; Wenk, Alexander; Sahu, Manoranjan; Deppert, Knut; Cydzik, Izabela; Wigge, Christoph; Schmid, Otmar; Semmler-Behnke, Manuela (2011). Generation and characterization of stable, highly concentrated titanium dioxide nanoparticle aerosols for rodent inhalation studies. Journal of Nanoparticle Research, 13(2), pp. 511-524. Dordrecht: Springer 10.1007/s11051-010-0081-5
Journal of Nanoparticle Research
Kreyling, Wolfgang G.; Biswas, Pratim; Messing, Maria E.; Gibson, Neil; Geiser, Marianne; Wenk, Alexander; Sahu, Manoranjan; Deppert, Knut; Cydzik, Izabela; Wigge, Christoph; Schmid, Otmar; Semmler-Behnke, Manuela (2011). Generation and characterization of stable, highly concentrated titanium dioxide nanoparticle aerosols for rodent inhalation studies. Journal of Nanoparticle Research, 13(2), pp. 511-524. Dordrecht: Springer 10.1007/s11051-010-0081-5
The intensive use of nano sized titanium dioxide (TiO2) particles in many different applications necessitates studies on their risk assessment as there are still open questions on their safe handling and utilization. For reliable risk assessment the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8af6ed59613e280b07f327900344186f