Homologue replacement in the import motor of the mitochondrial inner membrane of trypanosomes

Autor: Corinne von Känel, Sergio A Muñoz-Gómez, Silke Oeljeklaus, Christoph Wenger, Bettina Warscheid, Jeremy G Wideman, Anke Harsman, Andre Schneider

Publikováno v: eLife, Vol 9 (2020)

Many mitochondrial proteins contain N-terminal presequences that direct them to the organelle. The main driving force for their translocation across the inner membrane is provided by the presequence translocase-associated motor (PAM) which contains t

Externí odkaz: https://doaj.org/article/9c4bc4289c1c4c3c85fd4f7b63d6d87a

The non-canonical mitochondrial inner membrane presequence translocase of trypanosomatids contains two essential rhomboid-like proteins

Autor: Anke Harsman, Silke Oeljeklaus, Christoph Wenger, Jonathan L. Huot, Bettina Warscheid, André Schneider

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)

The mitochondrial protein import machinery is crucial for eukaryotes but little is known about its evolutionary origin. Here, the authors characterize the translocase of the inner membrane (TIM) in trypanosomes, showing that it contains two rhomboid-

Externí odkaz: https://doaj.org/article/71e9d79a4a73445c930fdcca41bf6ec0

Correction: Corrigendum: The non-canonical mitochondrial inner membrane presequence translocase of trypanosomatids contains two essential rhomboid-like proteins

Autor: Anke Harsman, Silke Oeljeklaus, Christoph Wenger, Jonathan L. Huot, Bettina Warscheid, André Schneider

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017)

Nature Communications 7: Article number:13707 (2016); Published: 19 December 2016; Updated: 30 June 2017 The original version of this Article contained an error in the gene ID for TimRhom I, cited in the Methods, which specified an unrelated gene. Th

Externí odkaz: https://doaj.org/article/69edd1feb5384e1fb09d28c9a19f7823

The Mba1 homologue ofTrypanosoma bruceiis involved in the biogenesis of oxidative phosphorylation complexes

Autor: Christoph Wenger, Anke Harsman, Moritz Niemann, Silke Oeljeklaus, Corinne von Känel, Salvatore Calderaro, Bettina Warscheid, André Schneider

Consistent with other eukaryotes, theTrypanosoma bruceimitochondrial genome encodes mainly hydrophobic core subunits of the oxidative phosphorylation system. These proteins must be co-translationally inserted into the inner mitochondrial membrane and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd5584b4e3c11e2936ce8ea9d9f052af
https://doi.org/10.1101/2022.12.21.521360

Minimal peptide length required to span the mitochondrial protein translocases in Trypanosoma brucei

Autor: André Schneider, Christoph Wenger

Publikováno v: Wenger, Christoph; Schneider, André (2021). Minimal peptide length required to span the mitochondrial protein translocases in Trypanosoma brucei. Molecular and biochemical parasitology, 244, p. 111393. Elsevier 10.1016/j.molbiopara.2021.111393

Mitochondrial protein import depends on heterooligomeric translocases in the outer and inner membranes. Using import substrates consisting of various lengths of the N-terminal part of mitochondrial dihydrolipoamide dehydrogenase (LDH) fused to dihydr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0cce272f3da5620c0b24c1e809e2b43
https://pubmed.ncbi.nlm.nih.gov/34197864