Výsledky vyhledávání - "Christoph Wenger"

Akademický článek

Homologue replacement in the import motor of the mitochondrial inner membrane of trypanosomes

Autor: Corinne von Känel, Sergio A Muñoz-Gómez, Silke Oeljeklaus, Christoph Wenger, Bettina Warscheid, Jeremy G Wideman, Anke Harsman, Andre Schneider

Publikováno v: eLife, Vol 9 (2020)

Many mitochondrial proteins contain N-terminal presequences that direct them to the organelle. The main driving force for their translocation across the inner membrane is provided by the presequence translocase-associated motor (PAM) which contains t

Externí odkaz: https://doaj.org/article/9c4bc4289c1c4c3c85fd4f7b63d6d87a

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Akademický článek

Charting organellar importomes by quantitative mass spectrometry

Autor: Christian D. Peikert, Jan Mani, Marcel Morgenstern, Sandro Käser, Bettina Knapp, Christoph Wenger, Anke Harsman, Silke Oeljeklaus, André Schneider, Bettina Warscheid

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)

Knowing the specific protein content of individual organelles is necessary for an integrated understanding of cellular physiology. Here the authors describe a mass spectrometry-based approach to identify the substrates of distinct protein import path

Externí odkaz: https://doaj.org/article/bf7073abf7dd409ea6d6cecc74034615

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Akademický článek

The non-canonical mitochondrial inner membrane presequence translocase of trypanosomatids contains two essential rhomboid-like proteins

Autor: Anke Harsman, Silke Oeljeklaus, Christoph Wenger, Jonathan L. Huot, Bettina Warscheid, André Schneider

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)

The mitochondrial protein import machinery is crucial for eukaryotes but little is known about its evolutionary origin. Here, the authors characterize the translocase of the inner membrane (TIM) in trypanosomes, showing that it contains two rhomboid-

Externí odkaz: https://doaj.org/article/71e9d79a4a73445c930fdcca41bf6ec0

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The Mba1 homologue ofTrypanosoma bruceiis involved in the biogenesis of oxidative phosphorylation complexes

Autor: Christoph Wenger, Anke Harsman, Moritz Niemann, Silke Oeljeklaus, Corinne von Känel, Salvatore Calderaro, Bettina Warscheid, André Schneider

Consistent with other eukaryotes, theTrypanosoma bruceimitochondrial genome encodes mainly hydrophobic core subunits of the oxidative phosphorylation system. These proteins must be co-translationally inserted into the inner mitochondrial membrane and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd5584b4e3c11e2936ce8ea9d9f052af
https://doi.org/10.1101/2022.12.21.521360

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Akademický článek

A trypanosomal orthologue of an intermembrane space chaperone has a non-canonical function in biogenesis of the single mitochondrial inner membrane protein translocase.

Autor: Christoph Wenger, Silke Oeljeklaus, Bettina Warscheid, André Schneider, Anke Harsman

Publikováno v: PLoS Pathogens, Vol 13, Iss 8, p e1006550 (2017)

Mitochondrial protein import is essential for Trypanosoma brucei across its life cycle and mediated by membrane-embedded heterooligomeric protein complexes, which mainly consist of trypanosomatid-specific subunits. However, trypanosomes contain ortho

Externí odkaz: https://doaj.org/article/467563981f704ad3a7a11b3439f25d59

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Characterization of a highly diverged mitochondrial ATP synthase F

Autor: Caroline E, Dewar, Silke, Oeljeklaus, Christoph, Wenger, Bettina, Warscheid, André, Schneider

Publikováno v: The Journal of biological chemistry. 298(4)

The mitochondrial F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f3561cf436c2e0d7535c39b1a89c82aa
https://pubmed.ncbi.nlm.nih.gov/35293314

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Akademický článek

Correction: Corrigendum: The non-canonical mitochondrial inner membrane presequence translocase of trypanosomatids contains two essential rhomboid-like proteins

Autor: Anke Harsman, Silke Oeljeklaus, Christoph Wenger, Jonathan L. Huot, Bettina Warscheid, André Schneider

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017)

Nature Communications 7: Article number:13707 (2016); Published: 19 December 2016; Updated: 30 June 2017 The original version of this Article contained an error in the gene ID for TimRhom I, cited in the Methods, which specified an unrelated gene. Th

Externí odkaz: https://doaj.org/article/69edd1feb5384e1fb09d28c9a19f7823

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Minimal peptide length required to span the mitochondrial protein translocases in Trypanosoma brucei

Autor: André Schneider, Christoph Wenger

Publikováno v: Wenger, Christoph; Schneider, André (2021). Minimal peptide length required to span the mitochondrial protein translocases in Trypanosoma brucei. Molecular and biochemical parasitology, 244, p. 111393. Elsevier 10.1016/j.molbiopara.2021.111393

Mitochondrial protein import depends on heterooligomeric translocases in the outer and inner membranes. Using import substrates consisting of various lengths of the N-terminal part of mitochondrial dihydrolipoamide dehydrogenase (LDH) fused to dihydr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0cce272f3da5620c0b24c1e809e2b43
https://pubmed.ncbi.nlm.nih.gov/34197864

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