Zobrazeno 1 - 10
of 259
pro vyhledávání: '"Christoph W, Turck"'
Autor:
Xiaosong Liu, Bozidar Novak, Christian Namendorf, Barbara Steigenberger, Yaoyang Zhang, Christoph W. Turck
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109642- (2024)
Summary: Protein turnover is an important mechanism to maintain proteostasis. Long-lived proteins (LLPs) are vulnerable to lose their function due to time-accumulated damages. In this study we employed in vivo stable isotope labeling in mice from bir
Externí odkaz:
https://doaj.org/article/56f22a709b5f4854ad3a4f405ed9b170
Autor:
Jianglei Xu, Hao Li, Yingzhou Hu, Shihao Wu, Liping Wu, Xiaoguang Lei, Longbao Lv, Yi Lu, Jing Wu, Juanjuan Li, Bingyin Shi, Jiali Li, Christoph W. Turck, Wenchao Wang, Xintian Hu
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109436- (2024)
Summary: Cerebrospinal fluid (CSF) samples are commonly collected via lumbar puncture (LP) in both clinical and research settings for measurement of biomarkers of Alzheimer’s disease (AD). To determine the effects of LP on CSF AD biomarkers, we col
Externí odkaz:
https://doaj.org/article/fa9e59c45ecd4c93a7458dd633878e0f
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Integrative analysis of the high-resolution baboon diurnal transcriptome, provides insights into the effect of circadian rhythm on the whole-body primate gene network.
Externí odkaz:
https://doaj.org/article/43203f45f5cf4e2097175e00c316a535
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/a8df20d567694d598f3db62002f941b1
Autor:
Lauren E. Chaby, Heather C. Lasseter, Kévin Contrepois, Reza M. Salek, Christoph W. Turck, Andrew Thompson, Timothy Vaughan, Magali Haas, Andreas Jeromin
Publikováno v:
Metabolites, Vol 13, Iss 8, p 933 (2023)
In the original publication [...]
Externí odkaz:
https://doaj.org/article/7ad78cb621a04d90adceaff87ccd110f
Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion
Autor:
Silvia Martinelli, Elmira A. Anderzhanova, Thomas Bajaj, Svenja Wiechmann, Frederik Dethloff, Katja Weckmann, Daniel E. Heinz, Tim Ebert, Jakob Hartmann, Thomas M. Geiger, Michael Döngi, Kathrin Hafner, Max L. Pöhlmann, Lee Jollans, Alexandra Philipsen, Susanne V. Schmidt, Ulrike Schmidt, Giuseppina Maccarrone, Valentin Stein, Felix Hausch, Christoph W. Turck, Mathias V. Schmidt, Anne-Kathrin Gellner, Bernhard Kuster, Nils C. Gassen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Glucocorticoids are associated with stress. Here, the authors show that high levels of glucocorticoid stress promote secretory autophagy of matrix metalloproteinase 9 via a stress responsive chaperone, increasing brain-derived neurotrophic factor pro
Externí odkaz:
https://doaj.org/article/4b82f8ddb5c141baac1137b7deee6057
Autor:
Cristina Contini, Simone Serrao, Barbara Manconi, Alessandra Olianas, Federica Iavarone, Giulia Guadalupi, Irene Messana, Massimo Castagnola, Carlo Masullo, Alessandra Bizzarro, Christoph W. Turck, Giuseppina Maccarrone, Tiziana Cabras
Publikováno v:
Life, Vol 13, Iss 3, p 748 (2023)
Cystatin B is a small, multifunctional protein involved in the regulation of inflammation, innate immune response, and neuronal protection and found highly abundant in the brains of patients with Alzheimer’s disease (AD). Recently, our study demons
Externí odkaz:
https://doaj.org/article/5039240eb1db4415a408f3c1a8dea72b
Publikováno v:
BMC Molecular and Cell Biology, Vol 22, Iss 1, Pp 1-10 (2021)
Abstract Background Most of the cells of the mammalian retina are terminally differentiated, and do not regenerate once fully developed. This implies that these cells have strict controls over their metabolic processes, including protein turnover. We
Externí odkaz:
https://doaj.org/article/cd433313723a4106a323491c1f4cf8d8
Publikováno v:
Molecular Brain, Vol 13, Iss 1, Pp 1-4 (2020)
Abstract Synaptic proteins play an important role for the regulation of synaptic plasticity. Numerous studies have identified and revealed individual synaptic protein functions using protein overexpression or deletion. In neuropathic pain nociceptive
Externí odkaz:
https://doaj.org/article/761f8e41f7354c25a381da33eb28635d
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 1914-1924 (2020)
Circadian rhythms are 24-hour oscillations affecting an organism at multiple levels from gene expression all the way to tissues and organs. They have been observed in organisms across the kingdom of life, spanning from cyanobacteria to humans. In mam
Externí odkaz:
https://doaj.org/article/391f9a8eaba6486f93931e8e5913a9f8