Zobrazeno 1 - 10
of 253
pro vyhledávání: '"Christoph Thiele"'
Autor:
Suzan Elmaagacli, Christoph Thiele, Franziska Meister, Philipp Menne, Daniel Truhn, Steven W. M. Olde Damink, Johannes Bickenbach, Ulf Neumann, Sven Arke Lang, Florian Vondran, Iakovos Amygdalos
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Colorectal liver metastases (CRLM) are the predominant factor limiting survival in patients with colorectal cancer and liver resection with complete tumor removal is the best treatment option for these patients. This study examines the predi
Externí odkaz:
https://doaj.org/article/2a89fe375ca540c5893316f515fd248a
Autor:
Frederike J. Graelmann, Fabian Gondorf, Yasmin Majlesain, Birte Niemann, Katarina Klepac, Dominic Gosejacob, Marlene Gottschalk, Michelle Mayer, Irina Iriady, Philip Hatzfeld, Sophie K. Lindenberg, Klaus Wunderling, Christoph Thiele, Zeinab Abdullah, Wei He, Karsten Hiller, Kristian Händler, Marc D. Beyer, Thomas Ulas, Alexander Pfeifer, Charlotte Esser, Heike Weighardt, Irmgard Förster, Laia Reverte-Salisa
Publikováno v:
Molecular Metabolism, Vol 85, Iss , Pp 101963- (2024)
Objective: The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor regulating xenobiotic responses as well as physiological metabolism. Dietary AhR ligands activate the AhR signaling axis, whereas AhR activation is negatively r
Externí odkaz:
https://doaj.org/article/0c77233a1c3641c5b95ff046ca0f1936
Autor:
Kevin Baßler, Wataru Fujii, Theodore S. Kapellos, Erika Dudkin, Nico Reusch, Ari Horne, Benedikt Reiz, Malte D. Luecken, Collins Osei-Sarpong, Stefanie Warnat-Herresthal, Lorenzo Bonaguro, Jonas Schulte-Schrepping, Allon Wagner, Patrick Günther, Carmen Pizarro, Tina Schreiber, Rainer Knoll, Lisa Holsten, Charlotte Kröger, Elena De Domenico, Matthias Becker, Kristian Händler, Christian T. Wohnhaas, Florian Baumgartner, Meike Köhler, Heidi Theis, Michael Kraut, Marc H. Wadsworth, Travis K. Hughes, Humberto J. Ferreira, Emily Hinkley, Ines H. Kaltheuner, Matthias Geyer, Christoph Thiele, Alex K. Shalek, Andreas Feißt, Daniel Thomas, Henning Dickten, Marc Beyer, Patrick Baum, Nir Yosef, Anna C. Aschenbrenner, Thomas Ulas, Jan Hasenauer, Fabian J. Theis, Dirk Skowasch, Joachim L. Schultze
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Despite its high prevalence, the cellular and molecular mechanisms of chronic obstructive pulmonary disease (COPD) are far from being understood. Here, we determine disease-related changes in cellular and molecular compositions within the alveolar sp
Externí odkaz:
https://doaj.org/article/e0f1f3d9372546f1a11d2fa5f19b33eb
Autor:
Lars Kuerschner, Christoph Thiele
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Lipid tracing studies are a key method to gain a better understanding of the complex metabolic network lipids are involved in. In recent years, alkyne lipid tracers and mass spectrometry have been developed as powerful tools for such studies. This st
Externí odkaz:
https://doaj.org/article/281ddd7467d342dc864ba231c0737276
Autor:
Lars Kuerschner, Philipp Leyendecker, Kristina Klizaite, Maria Fiedler, Jennifer Saam, Christoph Thiele
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 4, Pp 100188- (2022)
Fatty acid beta-oxidation is a key process in mammalian lipid catabolism. Disturbance of this process results in severe clinical symptoms, including dysfunction of the liver, a major beta-oxidizing tissue. For a thorough understanding of this process
Externí odkaz:
https://doaj.org/article/5b605ae5d5d04288b3c8fc2dd325205c
Autor:
Lea Hänschke, Christoph Heier, Santiago José Maya Palacios, Huseyin Erdem Özek, Christoph Thiele, Reinhard Bauer, Ronald P. Kühnlein, Margret H. Bülow
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
The human LIPA gene encodes for the enzyme lysosomal acid lipase, which hydrolyzes cholesteryl ester and triacylglycerol. Lysosomal acid lipase deficiency results in Wolman disease and cholesteryl ester storage disease. The Drosophila genome encodes
Externí odkaz:
https://doaj.org/article/153473ccf6b24bffb4a99506d3235db3
Autor:
Wataru Fujii, Theodore S. Kapellos, Kevin Baßler, Kristian Händler, Lisa Holsten, Rainer Knoll, Stefanie Warnat-Herresthal, Marie Oestreich, Emily R. Hinkley, Jan Hasenauer, Carmen Pizarro, Christoph Thiele, Anna C. Aschenbrenner, Thomas Ulas, Dirk Skowasch, Joachim L. Schultze
Publikováno v:
ERJ Open Research, Vol 7, Iss 3 (2021)
Background Immune cells play a major role in the pathogenesis of COPD. Changes in the distribution and cellular functions of major immune cells, such as alveolar macrophages (AMs) and neutrophils are well known; however, their transcriptional reprogr
Externí odkaz:
https://doaj.org/article/ba9c72944c8e44c0884c83b5d5ae110e
Autor:
Klaus Wunderling, Christina Leopold, Isabell Jamitzky, Mohamed Yaghmour, Fabian Zink, Dagmar Kratky, Christoph Thiele
Publikováno v:
Molecular Metabolism, Vol 45, Iss , Pp 101150- (2021)
Objective: Medium-chain fatty acids (MCFAs) play an increasing role in human nutrition. In the liver, one fraction is used for synthesis of MCFA-containing triacylglycerol (MCFA-TG), and the rest is used for oxidative energy production or ketogenesis
Externí odkaz:
https://doaj.org/article/55757cdfc7b44855b84f02becf6f3fac
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100022- (2021)
Phospholipids with a choline head group are an abundant component of cellular membranes and are involved in many important biological functions. For studies on the cell biology and metabolism of these lipids, traceable analogues where propargylcholin
Externí odkaz:
https://doaj.org/article/469108989d4d4af68131b561ffedb8a4
Autor:
Katrin Rabold, Gosse J Adema, Anna Aschenbrenner, Christoph Thiele, Collins K Boahen, Alexander Schiltmans, Johannes W A Smit, Joachim L Schultze, Romana T Netea-Maier
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background Tumor-associated macrophages (TAMs) are key components of the tumor microenvironment (TME) in non-medullary thyroid carcinoma (TC) and neuroblastoma (NB), being associated with a poor prognosis for patients. However, little is known about
Externí odkaz:
https://doaj.org/article/3294f8726d5844c5ad59e3f4c36af538