Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Christoph Stelzer"'
Publikováno v:
Cell Reports, Vol 33, Iss 9, Pp 108437- (2020)
Summary: Multi-input logic gene circuits can enable sophisticated control of cell function, yet large-scale synthetic circuitry in mammalian cells has relied on post-transcriptional regulation or recombinase-triggered state transitions. Large-scale t
Externí odkaz:
https://doaj.org/article/1c1ecda421324a288cda07be3cebf015
Autor:
Dennis Rokitta, Max Taubert, Britta Kaminsky, Martin L. Sos, Reinhard Buettner, Carsten Kobe, Diana S.Y. Abdulla, Christian Mattonet, Lucia Nogova, Martina Eichstaedt, Dirk Behringer, Sabine Merkelbach-Bruse, Sebastian Michels, Dongsheng Ouyang, Lisa Junge, Meike Limburg, Sebastian Frechen, Masyar Gardizi, Jürgen Wolf, Jeremy Franklin, Matthias Scheffler, Uwe Fuhr, Heiko Backes, Rieke Fischer, Thorsten Persigehl, Yingying Tian, Roland Schnell, Christoph Stelzer, Martina Kinzig, Fritz Sörgel, Ahmed Abbas Suleiman
Publikováno v:
Cancer Medicine
Cancer Medicine, Vol 9, Iss 14, Pp 4991-5007 (2020)
Cancer Medicine, Vol 9, Iss 14, Pp 4991-5007 (2020)
Background Treatment of patients with solid tumors and KRAS mutations remains disappointing. One option is the combined inhibition of pathways involved in RAF‐MEK‐ERK and PI3K‐AKT‐mTOR. Methods Patients with relapsed solid tumors were treated
Autor:
Max Taubert, Lisa Junge, Tobias Goeser, Christoph Stelzer, Anabelle von Georg, Sebastian Frechen, Chris Starke, Uwe Fuhr, Ulrich Jaehde, Xia Li, Ulrich Töx, Fritz Sörgel, Martina Kinzig, Dominik Dahlinger
The extent of a drug-drug interaction (DDI) mediated by cytochrome P450 (CYP) 3A inhibitors is highly variable during a dosing interval, as it depends on the temporal course of victim and perpetrator drug concentrations at intestinal and hepatic CYP3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d20bd09d778bee9bdf4f4b7914eb3548
https://www.ncbi.nlm.nih.gov/pubmed/32427354
https://www.ncbi.nlm.nih.gov/pubmed/32427354
Autor:
Uwe Fuhr, Fritz Sörgel, Michael Schroeter, Martina Kinzig, Ali Sigaroudi, Ulrike Holzgrabe, Christoph Stelzer, Oliver Wahl
Publikováno v:
Pharmacology. 101:29-34
Background: Bisoprolol and metoprolol are moderately lipophilic, beta(1)-selective betablockers reported to cause adverse effects in the central nervous system (CNS), such as sleep disturbance, suggesting that both drugs may reach relevant concentrat
Autor:
B. Moritz, Meta H M Diekstra, Fritz Sörgel, Ulrich Jaehde, Henk-Jan Guchelaar, K. Mross, Danny Houtsma, Christoph Stelzer, Achim Fritsch, Thomas Gauler, Egbert Oosterwijk, Lambertus A. Kiemeney, D J A R Moes, L. Bergmann, F. Kanefendt, Max Roessler, Stephen L. Hauser, Jesse J. Swen, Martina Kinzig, D. Schindele
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology. 6:604-613
The tyrosine kinase inhibitor sunitinib is used as first-line therapy in patients with metastasized renal cell carcinoma (mRCC), given in fixed-dose regimens despite its high variability in pharmacokinetics (PKs). Interindividual variability of drug
Autor:
Martin Wilhelm, Fritz Sörgel, M Vormittag, Rainer Höhl, Martin Munz, Ulrike Holzgrabe, Jürgen B. Bulitta, Martina Kinzig, Christoph Stelzer, Cornelia B. Landersdorfer, R Glaser, A Junger, Michael Christ
Publikováno v:
Medizinische Klinik - Intensivmedizin und Notfallmedizin. 112:11-23
Die optimale Dosierung von Antibiotika ist seit ihrer Einfuhrung unklar geblieben. In den letzten 20 Jahren wurden 3 Pharmakokinetik(PK)-Pharmakodynamik(PD)-Indizes etabliert, die von Messungen der Konzentration des Antibiotikums im Plasma und der mi
Publikováno v:
Cell Reports, Vol 33, Iss 9, Pp 108437-(2020)
Cell Reports, 33 (9)
Cell Reports, 33 (9)
Multi-input logic gene circuits can enable sophisticated control of cell function, yet large-scale synthetic circuitry in mammalian cells has relied on post-transcriptional regulation or recombinase-triggered state transitions. Large-scale transcript
Autor:
Bärbel Reiser, Dirk von Mallek, Stefan Boeck, Stefan Rüdiger, Volker Kächele, Tanusree Paul, Julia C. Stingl, Christian Schumann, Volker Heinemann, Vivien Hichert, Michael Steffens, Catharina Scholl, Thomas Seufferlein, Christoph Stelzer, Fritz Sörgel
Publikováno v:
European Journal of Cancer. 55:131-139
Aim The aim of this study was to investigate if biomarkers of individual drug metabolism, respectively, the erlotinib/O-desmethyl-erlotinib metabolic ratio, may be a predictive factor for the severity of erlotinib-mediated skin rash in epidermal grow
Autor:
Fritz Sörgel, Oliver Wahl, Christoph Stelzer, Ulrike Holzgrabe, Ali Sigaroudi, Uwe Fuhr, Martina Kinzig, Michael Schroeter
Publikováno v:
Pharmacology. 102(3-4)
Background: A drug must reach the central nervous system (CNS) in order to directly cause CNS adverse effects (AEs). Our current study addressed the pharmacokinetic (PK) background of the assumption that CNS concentrations of hydrochlorothiazide (HCT
Autor:
S. Hüttner, Martina Kinzig, Fritz Sörgel, Michael Schröter, Tina Braun, Uwe Fuhr, Christoph Stelzer, Ali Sigaroudi, Ulrike Holzgrabe, Sebastian Frechen
Publikováno v:
Pharmacology. 98:70-72
Background: Pantoprazole is a proton pump inhibitor drug mainly used for treating peptic diseases. Adverse effects of pantoprazole in the occasional central nervous system (CNS) include headache, vertigo and sleep disturbances. Data in rats suggest t