Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Christoph Schächtele"'
Autor:
Tim Fischer, Abdulkarim Najjar, Frank Totzke, Christoph Schächtele, Wolfgang Sippl, Christoph Ritter, Andreas Hilgeroth
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 1-8 (2018)
With ongoing resistance problems against the marketed EGFR inhibitors having a quinazoline core scaffold there is a need for the development of novel inhibitors having a modified scaffold and, thus, expected lower EGFR resistance problems. An additio
Externí odkaz:
https://doaj.org/article/6d896e3d34084d9bbe581c47b4ece265
Autor:
Cornelius Hempel, Frank Totzke, Christoph Schächtele, Abdulkarim Najjar, Wolfgang Sippl, Christoph Ritter, Andreas Hilgeroth
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 271-276 (2017)
Novel 4-benzylamino benzo-anellated pyrrolo[2,3-b]pyridines have been synthesized with varied substitution patterns both at the molecular scaffold of the benzo-anellated ring and at the 4-benzylamino residue. With a structural similarity to substitut
Externí odkaz:
https://doaj.org/article/2c52daa961da4a4d94af15b519b31366
Autor:
Max Holzer, Nico Schade, Ansgar Opitz, Isabel Hilbrich, Jens Stieler, Tim Vogel, Valentina Neukel, Moritz Oberstadt, Frank Totzke, Christoph Schächtele, Wolfgang Sippl, Andreas Hilgeroth
Publikováno v:
Molecules, Vol 23, Iss 9, p 2335 (2018)
The current number of drugs available for the treatment of Alzheimer’s disease (AD) is strongly limited and their benefit for therapy is given only in the early state of the disease. An effective therapy should affect those processes which mainly c
Externí odkaz:
https://doaj.org/article/540d8ad9361745d1b4fc2ae7d1220821
Autor:
Laurent Meijer, Vicente Notario, Jane A. Endicott, Aude Echalier, Benoît Joseph, Bernard Marquet, François Liger, Michael H.G. Kubbutat, Christoph Schächtele, Peter Drueckes, Silvia Mateo-Lozano, Jonathan C. Morris, Olivier Lozach, Yoan Ferandin, Séverine Marionneau-Lambot, Oscar M. Tirado, Karima Bettayeb
Protein kinases represent promising anticancer drug targets. We describe here the meriolins, a new family of inhibitors of cyclin-dependent kinases (CDK). Meriolins represent a chemical structural hybrid between meridianins and variolins, two familie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::862a2f4d144630c783bf14488d81f62d
https://doi.org/10.1158/0008-5472.c.6495774.v1
https://doi.org/10.1158/0008-5472.c.6495774.v1
Autor:
Laurent Meijer, Vicente Notario, Jane A. Endicott, Aude Echalier, Benoît Joseph, Bernard Marquet, François Liger, Michael H.G. Kubbutat, Christoph Schächtele, Peter Drueckes, Silvia Mateo-Lozano, Jonathan C. Morris, Olivier Lozach, Yoan Ferandin, Séverine Marionneau-Lambot, Oscar M. Tirado, Karima Bettayeb
Supplementary Figure 4 from Meriolins, a New Class of Cell Death–Inducing Kinase Inhibitors with Enhanced Selectivity for Cyclin-Dependent Kinases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be3970f1381a1112fc3eac3f8d94c493
https://doi.org/10.1158/0008-5472.22368006
https://doi.org/10.1158/0008-5472.22368006
Autor:
Laurent Meijer, Vicente Notario, Jane A. Endicott, Aude Echalier, Benoît Joseph, Bernard Marquet, François Liger, Michael H.G. Kubbutat, Christoph Schächtele, Peter Drueckes, Silvia Mateo-Lozano, Jonathan C. Morris, Olivier Lozach, Yoan Ferandin, Séverine Marionneau-Lambot, Oscar M. Tirado, Karima Bettayeb
Methods and Materials, Figure 4 Legend from Meriolins, a New Class of Cell Death–Inducing Kinase Inhibitors with Enhanced Selectivity for Cyclin-Dependent Kinases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::518409c14552a25e83b2c37283b71aa5
https://doi.org/10.1158/0008-5472.22368009
https://doi.org/10.1158/0008-5472.22368009
Autor:
Christoph Schächtele, Jan E. Ehlert, Ruben Gerardus George Leenders, Daniel Müller, Daniel Feger, Danny C. Lenstra, Jasmin Mecinović, Federica Trivarelli, Remco Zijlmans, Gerhard Müller, Bart van Bree, Anita Wegert, Marc van de Sande, Eddy Damen, Carolin Heidemann-Dinger, Michael H.G. Kubbutat
Publikováno v:
Bioorganic & Medicinal Chemistry Letters, 29, 2516-2524
Bioorganic & Medicinal Chemistry Letters, 29, 17, pp. 2516-2524
Bioorganic & Medicinal Chemistry Letters, 29, 17, pp. 2516-2524
Detailed structure activity relationship of two series of quinazoline EHMT1/EHMT2 inhibitors (UNC0224 and UNC0638) have been elaborated. New and active alternatives are presented for the ubiquitous substitution patterns found in literature for the li
Scaffold hopping identifies 6,8-disubstituted purines as novel anaplastic lymphoma kinase inhibitors
Autor:
Michael H.G. Kubbutat, Markus Immer, Frank Totzke, Lutz Preu, Conrad Kunick, Christoph Schächtele, Laura Schlütke
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 126:89-94
Rearrangements of anaplastic lymphoma kinase (ALK) are associated with several cancer diseases. Due to resistance development against existing ALK-inhibitors, new, structurally unrelated inhibitors are required. By a scaffold hopping strategy, 6,8-di
Autor:
Max Holzer, Frank Totzke, Volkmar Tell, Wolfgang Sippl, Andreas Hilgeroth, Inna Slynko, Isabel Hilbrich, Christoph Schächtele
Publikováno v:
Current Alzheimer Research. 13:1330-1336
So far monotargeted therapies in Alzheimers disease (AD) led to insufficient results. Slight improvements in the AD symptomatics have been limited to patients in the early stage of the disease. So multitargeting approaches have been started addressin
Autor:
Janette Beshay, Peter Jantscheff, Holger Weber, Christoph Schächtele, Cynthia Obodozie, Thomas Lemarchand
Publikováno v:
Cancers
Volume 11
Issue 2
Cancers, Vol 11, Iss 2, p 242 (2019)
Volume 11
Issue 2
Cancers, Vol 11, Iss 2, p 242 (2019)
In this second study, we established syngeneic in vivo models named carcinogen-induced mouse-derived isografts (cMDIs). Carcinogen-induced tumors were obtained during short-term observation (3&ndash
9 months) of CBA/J mice treated with various a
9 months) of CBA/J mice treated with various a