Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Christoph Sauvant"'
Publikováno v:
Cellular Physiology and Biochemistry, Vol 37, Iss 1, Pp 1-13 (2015)
Background: Recently, we gained evidence that impairment of rOat1 and rOat3 expression induced by ischemic acute kidney injury (AKI) is mediated by COX metabolites and this suppression might be critically involved in renal damage. Methods: (i) Basola
Externí odkaz:
https://doaj.org/article/0b22ea4a6a0d418db43e2b7502aa86d8
Autor:
Andreas Benesic, Gerald Schwerdt, Isabell Hennemeier, Christoph Sauvant, Sigrid Mildenberger, Michael Gekle
Publikováno v:
Cellular Physiology and Biochemistry, Vol 33, Iss 4, Pp 1106-1116 (2014)
Background/Aims: Chronic renal proximal tubule dysfunction after therapy with the antineoplastic agent ifosfamide (IFO) is often attributed to the metabolite chloroacetaldehyde (CAA). Chronic IFO-nephropathy is reported to result in tubulointerstitia
Externí odkaz:
https://doaj.org/article/55684ea6c0bd4cd0bcbef156d82431e8
Autor:
Boris Betz, Reinhard Schneider, Tobias Kress, Martin Alexander Schick, Christoph Wanner, Christoph Sauvant
Publikováno v:
PPAR Research, Vol 2012 (2012)
Background. Nitric oxide (NO)-signal transduction plays an important role in renal ischemia/reperfusion (I/R) injury. NO produced by endothelial NO-synthase (eNOS) has protective functions whereas NO from inducible NO-synthase (iNOS) induces impairme
Externí odkaz:
https://doaj.org/article/0922dbc7b3ef48198283f5542ae23aed
Autor:
Anne Riemann, Bettina Schneider, Angelika Ihling, Martin Nowak, Christoph Sauvant, Oliver Thews, Michael Gekle
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22445 (2011)
Tumor micromilieu often shows pronounced acidosis forcing cells to adapt their phenotype towards enhanced tumorigenesis induced by altered cellular signalling and transcriptional regulation. In the presents study mechanisms and potential consequences
Externí odkaz:
https://doaj.org/article/0d75850393cb4482843486f8a0ee811d
Autor:
Christoph Sauvant, Michael Gekle, Christopher Held, Marcus Meusel, Maike Büttner-Herold, Kerstin Möller-Ehrlich, Reinhard Schneider, Boris Betz, Christoph Wanner
Publikováno v:
American Journal of Physiology-Renal Physiology. 308:F198-F208
Expression of proximal tubular organic anion transporters Oat1 and Oat3 is reduced by PGE2after renal ischemia and reperfusion (I/R) injury. We hypothesized that impaired expression of Oat1/3 is decisively involved in the deterioration of renal funct
Autor:
Serge C. Thal, Christoph Sauvant, Maria Gerasimova, Ivan Sabolić, Anne Sebastiani, Ivana Vrhovac, Michael Rose, Hermann Koepsell, Volker Vallon, Davorka Breljak, Daniela Balen Eror, Marija Ljubojević, Hrvoje Brzica, Helmut Kipp
Publikováno v:
American Journal of Physiology-Cell Physiology. 302:C1174-C1188
With a novel antibody against the rat Na+-d-glucose cotransporter SGLT2 (rSGLT2-Ab), which does not cross-react with rSGLT1 or rSGLT3, the ∼75-kDa rSGLT2 protein was localized to the brush-border membrane (BBM) of the renal proximal tubule S1 and S
Autor:
M. Roeder, M. Meusel, S. Renker, Reinhard Schneider, C. Bauer, Hildegard Holzinger, Christoph Sauvant, Christoph Wanner, Michael Gekle
Publikováno v:
American Journal of Physiology-Renal Physiology. 297:F1614-F1621
We have previously shown that expression of renal organic anion transporters Oat1 and Oat3 is diminished by prostaglandin E2 (PGE2) and that both transporters are downregulated after renal ischemia. Because PGE2 is increased after renal ischemia and
Autor:
Christoph Wanner, Christoph Sauvant, Reinhard Schneider, Michael Gekle, Sylvia Renker, Hildegard Holzinger
Publikováno v:
Cellular Physiology and Biochemistry. 24:567-576
Ischemic acute kidney injury (iAKI) is a common event in organ transplantation and may occur during severe surgery. To gain mechanistic insights into ischemia-induced alterations at the level of proximal tubule cells we set up an in vitro model of is
Publikováno v:
Analytical Biochemistry. 381:81-85
The cytostatic drug daunorubicin exerts its toxic action by intercalating into the DNA. The efficacy of daunorubicin depends on the intracellular amount in the tumor cell. Here we have evaluated the use of a multiwell-multilabel reader for the direct
Publikováno v:
Cellular Physiology and Biochemistry, Vol 37, Iss 1, Pp 1-13 (2015)
Background: Recently, we gained evidence that impairment of rOat1 and rOat3 expression induced by ischemic acute kidney injury (AKI) is mediated by COX metabolites and this suppression might be critically involved in renal damage. Methods: (i) Basola
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f287530b8ca3fcd8cf35e32ec37620f
https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/14450
https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/14450