Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Christoph S N Klose"'
Eomes cannot replace its paralog T-bet during expansion and differentiation of CD8 effector T cells.
Autor:
Jonas Fixemer, Jonas F Hummel, Frederic Arnold, Christoph S N Klose, Alexis Hofherr, Kristoffer Weissert, Tamara Kögl, Michael Köttgen, Sebastian J Arnold, Peter Aichele, Yakup Tanriver
Publikováno v:
PLoS Pathogens, Vol 16, Iss 9, p e1008870 (2020)
The two T-box transcription factors T-bet and Eomesodermin (Eomes) are important regulators of cytotoxic lymphocytes (CTLs), such as activated CD8 T cells, which are essential in the fight against intracellular pathogens and tumors. Both transcriptio
Externí odkaz:
https://doaj.org/article/59bf0be84e5b40e89dd6faa33ec58339
Autor:
Karoline F. Troch, Manuel O. Jakob, Patrycja M. Forster, Katja J. Jarick, Jonathan Schreiber, Alexandra Preusser, Gabriela M. Guerra, Pawel Durek, Caroline Tizian, Nele Sterczyk, Sofia Helfrich, Claudia U. Duerr, David Voehringer, Mario Witkowski, David Artis, Tim Rollenske, Andrey A. Kruglov, Mir-Farzin Mashreghi, Christoph S. N. Klose
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Tissue-resident immune cells, such as innate lymphoid cells, mediate protective or detrimental immune responses at barrier surfaces. Upon activation by stromal or epithelial cell-derived alarmins, group 2 innate lymphoid cells (ILC2s) are a
Externí odkaz:
https://doaj.org/article/dd935caff54143fd88f4d75ee1b90bea
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Recent advancements in mucosal immunology have unveiled a complex network of intercellular connections within diverse tissues, shedding light on the unique properties of different cell types. Central to this intricate network is the cytokine IL-33, w
Externí odkaz:
https://doaj.org/article/b6fd3d5062d640278809b587b344a3a2
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/7ba6a339ef7148978d15636752b00522
Autor:
Patrycja M. Topczewska, Zoe A. Rompe, Manuel O. Jakob, Anton Stamm, Pierre S. Leclère, Alexandra Preußer, Claudia U. Duerr, Linda Marie Laura Thole, Katja Kotsch, David Artis, Christoph S. N. Klose
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The initiation of type 2 immune responses at mucosal barriers is regulated by rapidly secreted cytokines called alarmins. The alarmins IL-33, IL-25 and TSLP are mainly secreted by stromal and epithelial cells in tissues and were linked to chronic inf
Externí odkaz:
https://doaj.org/article/f67c4a577baa4cffac9aef09c0ae5cf0
Autor:
Benedikt Thelen, Vincent Schipperges, Paulina Knörlein, Jonas F. Hummel, Frederic Arnold, Laurence Kupferschmid, Christoph S. N. Klose, Sebastian J. Arnold, Melanie Boerries, Yakup Tanriver
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The T-box transcription factors T-bet and Eomesodermin regulate type 1 immune responses in innate and adaptive lymphocytes. T-bet is widely expressed in the immune system but was initially identified as the lineage-specifying transcription factor of
Externí odkaz:
https://doaj.org/article/4c5f1626cfc8418480d9a58bd7d61b97
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/2a6f3a3e2bb747e6923a4d1c6c8f1e49
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/098c7e550d344a51978f13bbd50df21f
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
After being described in the 1970s as cytotoxic cells that do not require MHC-dependent pre-activation, natural killer (NK) cells remained the sole member of innate lymphocytes for decades until lymphoid tissue-inducer cells in the 1990s and helper-l
Externí odkaz:
https://doaj.org/article/9b60b8885b834bb5818e47c15607b429
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The dense innervation of the gastro-intestinal tract with neuronal networks, which are in close proximity to immune cells, implies a pivotal role of neurons in modulating immune functions. Neurons have the ability to directly sense danger signals, ad
Externí odkaz:
https://doaj.org/article/1bd8bab3593f4e6fa68a1662a6ed7551