Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Christoph S, Clemen"'
Autor:
Carolin Berwanger, Dominic Terres, Dominik Pesta, Britta Eggers, Katrin Marcus, Ilka Wittig, Rudolf J. Wiesner, Rolf Schröder, Christoph S. Clemen
Publikováno v:
European Journal of Cell Biology, Vol 103, Iss 2, Pp 151399- (2024)
Desmin gene mutations cause myopathies and cardiomyopathies. Our previously characterised R349P desminopathy mice, which carry the ortholog of the common human desmin mutation R350P, showed marked alterations in mitochondrial morphology and function
Externí odkaz:
https://doaj.org/article/322edd1d0b5e42938e98a96645053b1d
Autor:
Rakesh Ganji, Joao A. Paulo, Yuecheng Xi, Ian Kline, Jiang Zhu, Christoph S. Clemen, Conrad C. Weihl, John G. Purdy, Steve P. Gygi, Malavika Raman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Inter-organellar contacts are hubs for several critical cellular processes, such as lipid synthesis. Here Ganji et al. show that the p97-UBXD8 complex modulates contacts by regulating membrane lipid composition and saturation.
Externí odkaz:
https://doaj.org/article/ec8b699c1b3c422ea6b756578b81cfd6
Autor:
Janet Mansour, Carolin Berwanger, Marcel Jung, Ludwig Eichinger, Ben Fabry, Christoph S. Clemen
Publikováno v:
European Journal of Cell Biology, Vol 102, Iss 2, Pp 151330- (2023)
To study processes related to weightlessness in ground-based cell biological research, a theoretically assumed microgravity environment is typically simulated using a clinostat – a small laboratory device that rotates cell culture vessels with the
Externí odkaz:
https://doaj.org/article/cda03b84f76c49e5aa384e12e483ccb0
Autor:
Jiang Zhu, Sara Pittman, Dhruva Dhavale, Rachel French, Jessica N. Patterson, Mohamed Salman Kaleelurrrahuman, Yuanzi Sun, Jaime Vaquer-Alicea, Gianna Maggiore, Christoph S. Clemen, William J. Buscher, Jan Bieschke, Paul Kotzbauer, Yuna Ayala, Marc I. Diamond, Albert A. Davis, Conrad Weihl
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-25 (2022)
Abstract Background Neuronal uptake and subsequent spread of proteopathic seeds, such as αS (alpha-synuclein), Tau, and TDP-43, contribute to neurodegeneration. The cellular machinery participating in this process is poorly understood. One proteinop
Externí odkaz:
https://doaj.org/article/47c9b932aac447af8c16f13a657d0a0e
Autor:
Qiuhong Xiong, Rong Feng, Sarah Fischer, Malte Karow, Maria Stumpf, Susanne Meßling, Leonie Nitz, Stefan Müller, Christoph S. Clemen, Ning Song, Ping Li, Changxin Wu, Ludwig Eichinger
Publikováno v:
Cells, Vol 12, Iss 11, p 1514 (2023)
Autophagy and the ubiquitin proteasome system are the two major processes for the clearance and recycling of proteins and organelles in eukaryotic cells. Evidence is accumulating that there is extensive crosstalk between the two pathways, but the und
Externí odkaz:
https://doaj.org/article/b91cdcd1cd9e420688ca1b8b2fca1838
Autor:
Julia Schuld, Zacharias Orfanos, Frédéric Chevessier, Britta Eggers, Lorena Heil, Julian Uszkoreit, Andreas Unger, Gregor Kirfel, Peter F. M. van der Ven, Katrin Marcus, Wolfgang A. Linke, Christoph S. Clemen, Rolf Schröder, Dieter O. Fürst
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-19 (2020)
Abstract Filamin C (FLNc) is mainly expressed in striated muscle cells where it localizes to Z-discs, myotendinous junctions and intercalated discs. Recent studies have revealed numerous mutations in the FLNC gene causing familial and sporadic myopat
Externí odkaz:
https://doaj.org/article/ba3e1050cbf146d9a4a94ff8ab249a1a
Autor:
Jana Riehl, Ramesh Rijal, Leonie Nitz, Christoph S. Clemen, Andreas Hofmann, Ludwig Eichinger
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The abundant homohexameric AAA + ATPase p97 (also known as valosin-containing protein, VCP) is highly conserved from Dictyostelium discoideum to human and a pivotal factor of cellular protein homeostasis as it catalyzes the unfolding of proteins. Owi
Externí odkaz:
https://doaj.org/article/001bb8bd10004d5ca23ec3f7bb2cbecf
Autor:
Nane Eiber, Franziska Fröb, Mirjam Schowalter, Christian Thiel, Christoph S. Clemen, Rolf Schröder, Said Hashemolhosseini
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Desmin, the major intermediate filament (IF) protein in muscle cells, interlinks neighboring myofibrils and connects the whole myofibrillar apparatus to myonuclei, mitochondria, and the sarcolemma. However, desmin is also known to be enriched at post
Externí odkaz:
https://doaj.org/article/6017cf1596f149c0a79ffefa7a188735
Autor:
Florian Stöckigt, Lars Eichhorn, Thomas Beiert, Vincent Knappe, Tobias Radecke, Martin Steinmetz, Georg Nickenig, Viktoriya Peeva, Alexei P Kudin, Wolfram S Kunz, Carolin Berwanger, Lisa Kamm, Dorothea Schultheis, Ursula Schlötzer-Schrehardt, Christoph S Clemen, Rolf Schröder, Jan W Schrickel
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0228913 (2020)
BACKGROUND:Mutations in the human desmin gene (DES) cause autosomal-dominant and -recessive cardiomyopathies, leading to heart failure, arrhythmias, and AV blocks. We analyzed the effects of vascular pressure overload in a patient-mimicking p.R349P d
Externí odkaz:
https://doaj.org/article/9b3c7dcd411b41b8b55eb9e9f2bd2763
Autor:
Stefanie Diermeier, Julian Iberl, Kristina Vetter, Michael Haug, Charlotte Pollmann, Barbara Reischl, Andreas Buttgereit, Sebastian Schürmann, Marina Spörrer, Wolfgang H. Goldmann, Ben Fabry, Fatiha Elhamine, Robert Stehle, Gabriele Pfitzer, Lilli Winter, Christoph S. Clemen, Harald Herrmann, Rolf Schröder, Oliver Friedrich
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract In striated muscle, desmin intermediate filaments interlink the contractile myofibrillar apparatus with mitochondria, nuclei, and the sarcolemma. The desmin network’s pivotal role in myocytes is evident since mutations in the human desmin
Externí odkaz:
https://doaj.org/article/34b6157e38954bd2be2d2f1991aef0fe