Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Christoph Rosenbohm"'
Autor:
Nidhi Gupta, Niels Fisker, Marie-Claude Asselin, Marie Lindholm, Christoph Rosenbohm, Henrik Ørum, Joacim Elmén, Nabil G Seidah, Ellen Marie Straarup
Publikováno v:
PLoS ONE, Vol 5, Iss 5, p e10682 (2010)
The proprotein convertase subtilisin/kexin type 9 (PCSK9) is an important factor in the etiology of familial hypercholesterolemia (FH) and is also an attractive therapeutic target to reduce low density lipoprotein (LDL) cholesterol. PCSK9 accelerates
Externí odkaz:
https://doaj.org/article/19e6140d8bba4fac8a55f564acd212c1
Autor:
Niels Fisker, Ellen Marie Straarup, Henrik Ørum, Henrik Frydenlund Hansen, Christoph Rosenbohm, Jens Bo Hansen, Vibeke Aarup, Troels Koch, Marie Lindholm, Maj Hedtjärn
Publikováno v:
Nucleic Acids Research
The potency and specificity of locked nucleic acid (LNA) antisense oligonucleotides was investigated as a function of length and affinity. The oligonucleotides were designed to target apolipoprotein B (apoB) and were investigated both in vitro and in
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 27:37-42
The synthesis of LNA phosphoramidates is presented. The LNA phosphoramidates were evaluated for their ability to inhibit cell proliferation of the human prostate cancer cell line 15PC3. A number of the LNA phosphoramidates showed cell proliferation i
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:5440-5447
We have prepared a series of adenosine analogs based on the bicyclo[2.2.1]heptane scaffold of locked nucleic acid (LNA) and tested them for both agonist and antagonist activity at the adenosine A(3) receptor. The design of these derivatives was based
Publikováno v:
Carbohydrate Research. 338:637-649
The gelling properties of pectins are known to be closely related to the degree of methylation (DM) and the distribution of the ester groups. In order to investigate this dependency, a natural citrus pectin (DM 64%) has been methylated to pectins wit
Autor:
Mads D. Sørensen, Troels Koch, Lotte-Emilie Larsen, Daniel Sejer Pedersen, Jesper Wengel, Signe M. Christensen, Christoph Rosenbohm
Publikováno v:
Organic & Biomolecular Chemistry. 1:655-663
In this paper we present revised and significantly improved synthetic routes to 2′-amino-LNA (locked nucleic acid). The optimal route is convergent with the synthesis of LNA monomers (“2′-oxy-LNA”) via a common intermediate obtained by a mild
Publikováno v:
Scopus-Elsevier
A highly efficient method for the preparation of LNA (Locked Nucleic Acid) phosphoramidite monomers with 2-cyanoethyl-N,N,N',N'-tetraisopropylphosphorodiamidite and 4,5-dicyanoimidazole has been devised. The quality of the phosphoramidites prepared i
Autor:
Martin Hendrix, and Christoph Rosenbohm, David D. Manning, Chi-Huey Wong, William A. Greenberg
Publikováno v:
Journal of the American Chemical Society. 120:8319-8327
A library of compounds based upon an aminoglucopyranoside core has been developed and screened for binding to RNA and specifically to 16S ribosomal RNA. The title molecules simplify the complexity of naturally occurring aminoglycoside antibiotics by
Autor:
Henrik Frydenlund Hansen, Ellen Marie Straarup, Marie Lindholm, Troels Koch, Henrik Ørum, Christoph Rosenbohm, Joacim Elmén, Marianne R. Møller, Niels Fisker, Robert Persson
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 20(2)
Proprotein convertase subtilisin/kexin type 9 (PCSK9) has emerged as a therapeutic target for the reduction of low-density lipoprotein cholesterol (LDL-C). PCSK9 increases the degradation of the LDL receptor, resulting in high LDL-C in individuals wi
Autor:
Niels Fisker, Ellen Marie Straarup, Michael Meldgaard, Jens Bo Hansen, Christoph Rosenbohm, Joachim Elmén, Maj Hedtjärn, Marie W. Lindblom, Henrik Hansen, Jacob Ravn
Publikováno v:
Collection Symposium Series.