Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Christoph Q Schmidt"'
Autor:
Josef Biber, Yassin Jabri, Sarah Glänzer, Aaron Dort, Patricia Hoffelner, Christoph Q. Schmidt, Oliver Bludau, Diana Pauly, Antje Grosche
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-21 (2024)
Abstract Inherited, age-related, and acute retinal diseases are often exacerbated by an aberrant or excessive activity of the complement system. Consequently, cells not directly affected by an acute event or genetic variants may degenerate, resulting
Externí odkaz:
https://doaj.org/article/15a4bf0ad16e42119a105ca984e49f66
Autor:
Tanja Lucas, Karim Benihoud, Frédéric Vigant, Christoph Q Schmidt, Andreas Wortmann, Max G Bachem, Thomas Simmet, Stefan Kochanek
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117254 (2015)
Primary pancreatic carcinoma has an unfavourable prognosis and standard treatment strategies mostly fail in advanced cases. Virotherapy might overcome this resistance to current treatment modalities. However, data from clinical studies with oncolytic
Externí odkaz:
https://doaj.org/article/39e263ab526245c381a503ad613e2e16
Autor:
Patience B Tetteh-Quarcoo, Christoph Q Schmidt, Wai-Hong Tham, Richard Hauhart, Haydyn D T Mertens, Arthur Rowe, John P Atkinson, Alan F Cowman, J Alexandra Rowe, Paul N Barlow
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34820 (2012)
Complement receptor-type 1 (CR1, CD35) is the immune-adherence receptor, a complement regulator, and an erythroid receptor for Plasmodium falciparum during merozoite invasion and subsequent rosette formation involving parasitized and non-infected ery
Externí odkaz:
https://doaj.org/article/1bd17d28c12044c59c9376624a417214
Autor:
Hugh P Morgan, Haydyn D T Mertens, Mara Guariento, Christoph Q Schmidt, Dinesh C Soares, Dmitri I Svergun, Andrew P Herbert, Paul N Barlow, Jonathan P Hannan
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32187 (2012)
Factor H (FH) is a soluble regulator of the human complement system affording protection to host tissues. It selectively inhibits amplification of C3b, the activation-specific fragment of the abundant complement component C3, in fluid phase and on se
Externí odkaz:
https://doaj.org/article/867b87b33f8e47b6b339f77f3225b596
Autor:
Marco Mannes, Rebecca Halbgebauer, Lisa Wohlgemuth, David Alexander Christian Messerer, Susa Savukoski, Anke Schultze, Bettina Berger, Christiane Leonie Knapp, Christoph Q. Schmidt, Daniel Fürst, Morten Hillmer, Reiner Siebert, Oskar Eriksson, Barbro Persson, Bo Nilsson, Kristina Nilsson Ekdahl, Markus Huber-Lang
Publikováno v:
Journal of Innate Immunity, Vol 15, Iss 1, Pp 412-427 (2023)
The complement system plays a crucial role in host defense, homeostasis, and tissue regeneration and bridges the innate and the adaptive immune systems. Although the genetic variants in complement C2 (c.839_849+17del; p.(Met280Asnfs*5)) and C8B (c.16
Externí odkaz:
https://doaj.org/article/62eadcbb7b1441f18d52e79ef47787c9
Autor:
Murielle Golomingi, Jessie Kohler, Christina Lamers, Richard B. Pouw, Daniel Ricklin, József Dobó, Péter Gál, Gábor Pál, Bence Kiss, Arthur Dopler, Christoph Q. Schmidt, Elaissa Trybus Hardy, Wilbur Lam, Verena Schroeder
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundHaemostasis is a crucial process by which the body stops bleeding. It is achieved by the formation of a platelet plug, which is strengthened by formation of a fibrin mesh mediated by the coagulation cascade. In proinflammatory and prothromb
Externí odkaz:
https://doaj.org/article/6f75ad8a067c46fa8645d29059b9d3be
Autor:
Robin Nilson, Olivia Lübbers, Christoph Q. Schmidt, Markus Rojewski, Philip Helge Zeplin, Wolfgang Funk, Hubert Schrezenmeier, Astrid Kritzinger, Stefan Kochanek, Lea Krutzke
Publikováno v:
Molecular Therapy - Methods & Clinical Development. 25:96-110
In adenovirus type 5 (HAdV-5)-derived viral vectors, the fiber protein has been the preferred locale for modifications to alter the natural viral tropism. Hexon, the most abundant capsid protein, has rarely been used for retargeting purposes, likely
Autor:
Markus Anliker, Daniela Drees, Lorin Loacker, Susanne Hafner, Andrea Griesmacher, Gregor Hoermann, Vilmos Fux, Harald Schennach, Paul Hörtnagl, Arthur Dopler, Stefan Schmidt, Rosa Bellmann-Weiler, Günter Weiss, Astrid Marx-Hofmann, Sixten Körper, Britta Höchsmann, Hubert Schrezenmeier, Christoph Q. Schmidt
Publikováno v:
The Journal of Immunology. 208:1248-1258
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hemolytic disease driven by impaired complement regulation. Mutations in genes encoding the enzymes that build the GPI anchors are causative, with somatic mutations in the PIG-A gene occurring most
Autor:
Lorin Loacker, Janine Kimpel, Zoltán Bánki, Christoph Q. Schmidt, Andrea Griesmacher, Markus Anliker
Publikováno v:
Clinical chemistry and laboratory medicineReferences. 61(1)
Autor:
Clément Bechtler, Sophia Koutsogiannaki, Ekaterina Umnyakova, Amal Hamid, Avneesh Gautam, Yiannis Sarigiannis, Richard B. Pouw, Christina Lamers, Said Rabbani, Christoph Q. Schmidt, John D. Lambris, Daniel Ricklin
Publikováno v:
Acta biomaterialia. 155
The use of biomaterials in modern medicine has enabled advanced drug delivery strategies and led to reduced morbidity and mortality in a variety of interventions such as transplantation or hemodialysis. However, immune-mediated reactions still presen