Zobrazeno 1 - 10
of 358
pro vyhledávání: '"Christoph Peters"'
Autor:
Julia C. Kuehn, Patrick Metzger, Nicolas Neidert, Uta Matysiak, Linda Gräßel, Ulrike Philipp, Sabine Bleul, Thomas Pauli, Julia Falkenstein, Henriette Bertemes, Stepan Cysar, Maria Elena Hess, Anna Verena Frey, Jesús Duque-Afonso, Elisabeth Schorb, Marcia Machein, Jürgen Beck, Oliver Schnell, Nikolas von Bubnoff, Anna L. Illert, Christoph Peters, Tilman Brummer, Marco Prinz, Cornelius Miething, Heiko Becker, Silke Lassmann, Martin Werner, Melanie Börries, Justus Duyster, Dieter H. Heiland, Roman Sankowski, Florian Scherer
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-11 (2024)
Abstract Despite major advances in molecular profiling and classification of primary brain tumors, personalized treatment remains limited for most patients. Here, we explored the feasibility of individual molecular profiling and the efficacy of bioma
Externí odkaz:
https://doaj.org/article/1dc07143d8964d58a48d87e8eab4e848
Autor:
Stephanie Ketterer, Julia Mitschke, Anett Ketscher, Manuel Schlimpert, Wilfried Reichardt, Natascha Baeuerle, Maria Elena Hess, Patrick Metzger, Melanie Boerries, Christoph Peters, Bernd Kammerer, Tilman Brummer, Florian Steinberg, Thomas Reinheckel
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
The lysosomal aspartic protease Cathepsin D (CTSD) is associated with breast cancer progression. Here the authors show that selective inactivation of CTSD in mammary epithelium delays tumor onset due to impaired mTORC1 signaling, but resumes malignan
Externí odkaz:
https://doaj.org/article/081372ca21394e578d2d46c800e56a5a
Autor:
Stefan Joos, Dirk M. Nettelbeck, Anette Reil‐Held, Katja Engelmann, Alexandra Moosmann, Angelika Eggert, Wolfgang Hiddemann, Mechthild Krause, Christoph Peters, Martin Schuler, Klaus Schulze‐Osthoff, Hubert Serve, Wolfgang Wick, Josef Puchta, Michael Baumann
Publikováno v:
Molecular Oncology, Vol 13, Iss 3, Pp 535-542 (2019)
The German Cancer Consortium (‘Deutsches Konsortium für Translationale Krebsforschung’, DKTK) is a long‐term cancer consortium, bringing together the German Cancer Research Center (DKFZ), Germany's largest life science research center, and the
Externí odkaz:
https://doaj.org/article/52ff11e087e14d8197c990619a3e66d0
Autor:
Kazuichi Maruyama, Kazuhito Yoneda, Sunao Sugita, Yoshimi Yamamoto, Masato Koike, Christoph Peters, Yasuo Uchiyama, Kohji Nishida
Publikováno v:
Antioxidants, Vol 10, Iss 3, p 456 (2021)
Cytotoxic T lymphocyte antigen-2 (CTLA-2) alpha has been reported to suppress the activities of cathepsin L (Cath L), which is deeply involved in angiogenesis. Therefore, we assessed whether CTLA-2 alpha plays a role in angiogenesis in ocular tissue.
Externí odkaz:
https://doaj.org/article/239b3d1a65d84440ab979d239f097d64
Autor:
Susumu Ohkouchi, Masahiro Shibata, Mitsuho Sasaki, Masato Koike, Paul Safig, Christoph Peters, Shigekazu Nagata, Yasuo Uchiyama
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59148 (2013)
Deoxyribonuclease II (DNase II) is a key enzyme in the phagocytic digestion of DNA from apoptotic nuclei. To understand the molecular properties of DNase II, particularly the processing, we prepared a polyclonal antibody against carboxyl-terminal seq
Externí odkaz:
https://doaj.org/article/2b635b76b46a458cba798c9271b52792
Autor:
Frank Bühling, Martin Kouadio, Caroline E Chwieralski, Ursula Kern, Jens M Hohlfeld, Nicole Klemm, Nicole Friedrichs, Wera Roth, Jan M Deussing, Christoph Peters, Thomas Reinheckel
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26247 (2011)
BackgroundThe 11 human cysteine cathepsins are proteases mainly located in the endolysosomal compartment of all cells and within the exocytosis pathways of some secretory cell types. Cathepsin H (Ctsh) has amino- and endopeptidase activities. In vitr
Externí odkaz:
https://doaj.org/article/d5488f2d2d71445f9c6cd12707cc41c7
Autor:
Ludwig Czibere, Laura A Baur, Anke Wittmann, Katja Gemmeke, Andrea Steiner, Peter Weber, Benno Pütz, Nafees Ahmad, Mirjam Bunck, Cornelia Graf, Regina Widner, Claudia Kühne, Markus Panhuysen, Boris Hambsch, Gabriele Rieder, Thomas Reinheckel, Christoph Peters, Florian Holsboer, Rainer Landgraf, Jan M Deussing
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23604 (2011)
Behavioral endophenotypes are determined by a multitude of counteracting but precisely balanced molecular and physiological mechanisms. In this study, we aim to identify potential novel molecular targets that contribute to the multigenic trait "anxie
Externí odkaz:
https://doaj.org/article/5a2ad2e33cd54f34a13d737be0d182ea
Publikováno v:
Raumforschung und Raumordnung (2021)
Im Freistaat Bayern wird derzeit intensiv diskutiert, wie die nach wie vor hohe Freiflächeninanspruchnahme für Siedlungs- und Verkehrszwecke nachhaltig reduziert werden kann. Wissenschaftliche Grundlage für Steuerungsansätze in der Stadt- und Reg
Externí odkaz:
https://doaj.org/article/f405e04f86d149d1b92daadd6434a297
Publikováno v:
Raumforschung und Raumordnung, Vol 78, Iss 5 (2020)
The aim of this paper is to analyse the accessibility of outpatient care services in Lower Franconia, Germany, taking into account the spatially differentiated population structure for the year 2017 as well as the expected demographic development unt
Externí odkaz:
https://doaj.org/article/8cd79fabbab746e78f58040f0972c221
Autor:
Volker Arndt, Daniela Doege, Stefan Fröhling, Hana Algül, Ralf Bargou, Carsten Bokemeyer, Martin Bornhäuser, Christian H. Brandts, Peter Brossart, Sara Yvonne Brucker, Tim H. Brümmendorf, Norbert Gattermann, Michael Hallek, Volker Heinemann, Ulrich Keilholz, Thomas Kindler, Florian Lordick, Christoph Peters, Dirk Schadendorf, Stephan Stilgenbauer, Delia Braun, Thomas Seufferlein, Gerd Nettekoven, Michael Baumann
Publikováno v:
Forum. 37:372-376
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77275ae5aaf372e9e07fbcd1ac282edf
https://doi.org/10.1007/s12312-022-01121-4
https://doi.org/10.1007/s12312-022-01121-4