Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Christoph Patsch"'
Autor:
Panagiotis Douvaras, Diego F. Buenaventura, Bruce Sun, Ashley Lepack, Elizabeth Baker, Elizabeth Simpson, Mark Ebel, Gregory Lallos, Deven LoSchiavo, Nicholas Stitt, Nathaniel Adams, Conor McAuliffe, Ana Forton-Juarez, Brian Kosmyna, Elizabeth Pereira, Benjamin Burnett, David Dilworth, Stephanie Fisher, Jing Wang, Peter Tonge, Mark Tomishima, Carlos Paladini, Dan Wilkinson, Chew-Li Soh, Maya Srinivas, Christoph Patsch, Stefan Irion
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Mucopolysaccharidoses are inherited metabolic disorders caused by the deficiency in lysosomal enzymes required to break down glycosaminoglycans. Accumulation of glycosaminoglycans leads to progressive, systemic degenerative disease. The cent
Externí odkaz:
https://doaj.org/article/95c91876536349f0849eaac799da3482
Autor:
Florian Wanke, Simon Gutbier, Anna Rümmelin, Malte Steinberg, Lindsey D. Hughes, Mascha Koenen, Juliana Komuczki, Daniel Regan-Komito, Sagie Wagage, Julia Hesselmann, Ralf Thoma, Doris Brugger, Tony Christopeit, Hayian Wang, Floriane Point, Remy Hallet, Sourav Ghosh, Carla V. Rothlin, Christoph Patsch, Barbara Geering
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-13 (2021)
Abstract Removal of apoptotic cells by phagocytes (also called efferocytosis) is a crucial process for tissue homeostasis. Professional phagocytes express a plethora of surface receptors enabling them to sense and engulf apoptotic cells, thus avoidin
Externí odkaz:
https://doaj.org/article/01cf059ac626494a908897f862c90ad3
Autor:
Marvin Reich, Iñaki Paris, Martin Ebeling, Nadine Dahm, Christophe Schweitzer, Dieter Reinhardt, Roland Schmucki, Megana Prasad, Fabian Köchl, Marcel Leist, Sally A. Cowley, Jitao David Zhang, Christoph Patsch, Simon Gutbier, Markus Britschgi
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Microglia are key in the homeostatic well-being of the brain and microglial dysfunction has been implicated in neurodegenerative disorders such as Alzheimer’s disease (AD). Due to the many limitations to study microglia in situ or isolated for larg
Externí odkaz:
https://doaj.org/article/3bb1d84e6b0e42ef9025bb346883a564
Autor:
Viola Volpato, James Smith, Cynthia Sandor, Janina S. Ried, Anna Baud, Adam Handel, Sarah E. Newey, Frank Wessely, Moustafa Attar, Emma Whiteley, Satyan Chintawar, An Verheyen, Thomas Barta, Majlinda Lako, Lyle Armstrong, Caroline Muschet, Anna Artati, Carlo Cusulin, Klaus Christensen, Christoph Patsch, Eshita Sharma, Jerome Nicod, Philip Brownjohn, Victoria Stubbs, Wendy E. Heywood, Paul Gissen, Roberta De Filippis, Katharina Janssen, Peter Reinhardt, Jerzy Adamski, Ines Royaux, Pieter J. Peeters, Georg C. Terstappen, Martin Graf, Frederick J. Livesey, Colin J. Akerman, Kevin Mills, Rory Bowden, George Nicholson, Caleb Webber, M. Zameel Cader, Viktor Lakics
Publikováno v:
Stem Cell Reports, Vol 11, Iss 4, Pp 897-911 (2018)
Summary: Reproducibility in molecular and cellular studies is fundamental to scientific discovery. To establish the reproducibility of a well-defined long-term neuronal differentiation protocol, we repeated the cellular and molecular comparison of th
Externí odkaz:
https://doaj.org/article/de4461b1cd604cd1b890c370ecec071c
Autor:
Nadine Ruderisch, Daniel Schlatter, Andreas Kuglstatter, Wolfgang Guba, Sylwia Huber, Carlo Cusulin, Jörg Benz, Arne Christian Rufer, Joerg Hoernschemeyer, Christophe Schweitzer, Tina Bülau, Achim Gärtner, Eike Hoffmann, Jens Niewoehner, Christoph Patsch, Karlheinz Baumann, Hansruedi Loetscher, Eric Kitas, Per-Ola Freskgård
Publikováno v:
EBioMedicine, Vol 24, Iss C, Pp 76-92 (2017)
Therapeutic approaches to fight Alzheimer's disease include anti-Amyloidβ (Aβ) antibodies and secretase inhibitors. However, the blood-brain barrier (BBB) limits the brain exposure of biologics and the chemical space for small molecules to be BBB p
Externí odkaz:
https://doaj.org/article/316ddf067d1746b19366ae2a8f354fcb
Autor:
Anna Lisa Gündner, Claas Aiko Meyer, Stefan Aigner, Klaus Christensen, Christoph Patsch, Ravi Jagasia, Karlheinz Baumann, Mark Burcin
Publikováno v:
Stem Cell Research, Vol 23, Iss C, Pp 122-126 (2017)
We describe the generation of a biallelic GBA deletion human embryonic stem cell line using zinc finger nuclease-mediated gene targeting. The homozygous targeting of exon 4 of the GBA locus leads to a complete loss of glucocerebrosidase (GCase) prote
Externí odkaz:
https://doaj.org/article/5838bcb1393b448da8655a1d02142769
Autor:
Osele Ciampi, Roberto Iacone, Lorena Longaretti, Valentina Benedetti, Martin Graf, Maria Chiara Magnone, Christoph Patsch, Christodoulos Xinaris, Giuseppe Remuzzi, Ariela Benigni, Susanna Tomasoni
Publikováno v:
Stem Cell Research, Vol 17, Iss 1, Pp 130-139 (2016)
Generating human podocytes in vitro could offer a unique opportunity to study human diseases. Here, we describe a simple and efficient protocol for obtaining functional podocytes in vitro from human induced pluripotent stem cells. Cells were exposed
Externí odkaz:
https://doaj.org/article/167c2c0e6090410e8c10f32e85ce8309
Autor:
Veronica Costa, Stefan Aigner, Mirko Vukcevic, Evelyn Sauter, Katharina Behr, Martin Ebeling, Tom Dunkley, Arno Friedlein, Sannah Zoffmann, Claas A. Meyer, Frédéric Knoflach, Sebastian Lugert, Christoph Patsch, Fatiha Fjeldskaar, Laurie Chicha-Gaudimier, Anna Kiialainen, Paolo Piraino, Marc Bedoucha, Martin Graf, Sebastian Jessberger, Anirvan Ghosh, Josef Bischofberger, Ravi Jagasia
Publikováno v:
Cell Reports, Vol 15, Iss 1, Pp 86-95 (2016)
Hyperfunction of the mTORC1 pathway has been associated with idiopathic and syndromic forms of autism spectrum disorder (ASD), including tuberous sclerosis, caused by loss of either TSC1 or TSC2. It remains largely unknown how developmental processes
Externí odkaz:
https://doaj.org/article/c453283d07954edc80795548e6cfa550
Autor:
Maria Keramari, Janet Razavi, Karen A Ingman, Christoph Patsch, Frank Edenhofer, Christopher M Ward, Susan J Kimber
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e13952 (2010)
In preimplantation mammalian development the transcription factor Sox2 (SRY-related HMG-box gene 2) forms a complex with Oct4 and functions in maintenance of self-renewal of the pluripotent inner cell mass (ICM). Previously it was shown that Sox2-/-
Externí odkaz:
https://doaj.org/article/ba393582a3b8418ab6ff01fb5722071a
Autor:
Leonard D. Goldstein, Filip Roudnicky, Bo Kyoung Kim, Claas A. Meyer, Lisa Sach-Peltason, Nikhil J. Pandya, Klaus Christensen, Christoph Patsch, Héloïse Ragelle, Oliv Eidam, Chad A. Cowan, Martin Graf, Pamela Strassburger, Zora Modrusan, Mark Burcin, Balazs Banfai, Verena Kueppers, Manuel Tzouros, Mirjana Lazendic, Sabine Uhles, Gregor Sturm, Peter D. Westenskow, Franco Revelant, Yanjun Lan, Jitao David Zhang, Sabine Gruener
Publikováno v:
Proc Natl Acad Sci U S A
The blood–retina barrier and blood–brain barrier (BRB/BBB) are selective and semipermeable and are critical for supporting and protecting central nervous system (CNS)-resident cells. Endothelial cells (ECs) within the BRB/BBB are tightly coupled,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2681eba3f4ec57913642788bbe14e23c
https://doi.org/10.1073/pnas.1911532117
https://doi.org/10.1073/pnas.1911532117