Zobrazeno 1 - 10
of 271
pro vyhledávání: '"Christoph Otto"'
Autor:
Nodir Madrahimov, Vitalii Mutsenko, Ruslan Natanov, Dejan Radaković, André Klapproth, Mohamed Hassan, Mathias Rosenfeldt, Florian Kleefeldt, Ivan Aleksic, Süleyman Ergün, Christoph Otto, Rainer G. Leyh, Constanze Bening
Publikováno v:
Intensive Care Medicine Experimental, Vol 11, Iss 1, Pp 1-11 (2023)
Abstract Background Transplant candidates on the waiting list are increasingly challenged by the lack of organs. Most of the organs can only be kept viable within very limited timeframes (e.g., mere 4–6 h for heart and lungs exposed to refrigeratio
Externí odkaz:
https://doaj.org/article/11315af9a0834efeb5fb7a4243d1658c
Autor:
Catherine Kollmann, Hannah Buerkert, Michael Meir, Konstantin Richter, Kai Kretzschmar, Sven Flemming, Matthias Kelm, Christoph-Thomas Germer, Christoph Otto, Natalie Burkard, Nicolas Schlegel
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Loss of intestinal epithelial barrier function is a hallmark in digestive tract inflammation. The detailed mechanisms remain unclear due to the lack of suitable cell-based models in barrier research. Here we performed a detailed functional characteri
Externí odkaz:
https://doaj.org/article/d71f46b88e8f4861ad75c3186a252b27
Autor:
Olena Zaitseva, Annett Hoffmann, Margaretha Löst, Mohamed A. Anany, Tengyu Zhang, Kirstin Kucka, Armin Wiegering, Christoph Otto, Harald Wajant
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Fibroblast growth factor (FGF)-inducible 14 (Fn14) activates the classical and alternative NFκB (nuclear factor ‘kappa-light-chain-enhancer’ of activated B-cells) signaling pathway but also enhances tumor necrosis factor (TNF)-induced cell death
Externí odkaz:
https://doaj.org/article/86d88a2dc627496a9c30910e4ea2ab82
Autor:
Christoph Otto, Carolin Kastner, Stefanie Schmidt, Konstantin Uttinger, Apoorva Baluapuri, Sarah Denk, Mathias T. Rosenfeldt, Andreas Rosenwald, Florian Roehrig, Carsten P. Ade, Christina Schuelein‐Voelk, Markus E. Diefenbacher, Christoph‐Thomas Germer, Elmar Wolf, Martin Eilers, Armin Wiegering
Publikováno v:
Molecular Oncology, Vol 16, Iss 15, Pp 2788-2809 (2022)
Ribosomal biogenesis and protein synthesis are deregulated in most cancers, suggesting that interfering with translation machinery may hold significant therapeutic potential. Here, we show that loss of the tumor suppressor adenomatous polyposis coli
Externí odkaz:
https://doaj.org/article/86ca5923c6f34dcb85b7467dac7cbb83
Autor:
Florian Seyfried, Rebecca Springer, Annett Hoffmann, Maximilian Gruber, Christoph Otto, Nicolas Schlegel, Mohammed K. Hankir
Publikováno v:
Metabolism Open, Vol 17, Iss , Pp 100212- (2023)
Background: Roux-en-Y gastric bypass surgery (RYGB) improves glycemic control in individuals with severe obesity beyond the effects of weight loss alone. To identify potential underlying mechanisms, we asked how equivalent weight loss from RYGB and f
Externí odkaz:
https://doaj.org/article/652b33a937b54bfa962fac2a7ee4ecef
Autor:
Jessica Pauli, Tessa Reisenauer, Greg Winski, Nadja Sachs, Ekaterina Chernogubova, Hannah Freytag, Christoph Otto, Christian Reeps, Hans-Henning Eckstein, Claus-Jürgen Scholz, Lars Maegdefessel, Albert Busch
Publikováno v:
Biomolecules, Vol 13, Iss 7, p 1074 (2023)
Popliteal artery aneurysm (PAA) is the most frequent peripheral aneurysm, primarily seen in male smokers with a prevalence below 1%. This exploratory study aims to shed light on cellular mechanisms involved in PAA progression. Sixteen human PAA and e
Externí odkaz:
https://doaj.org/article/5a3b4a3811d74ba8b281dfc798a1ae6e
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Fibroblast growth factor-inducible 14 (Fn14) is a member of the tumor necrosis factor (TNF) receptor superfamily (TNFRSF) and is activated by its ligand TNF-like weak inducer of apoptosis (TWEAK). The latter occurs as a homotrimeric molecule in a sol
Externí odkaz:
https://doaj.org/article/5cb6a1d5af264062ae80896d64a16899
Autor:
Christoph Otto, Alexandra Friedrich, Ivana Vrhovac Madunić, Christian Baumeier, Robert W. Schwenk, Dean Karaica, Christoph-Thomas Germer, Annette Schürmann, Ivan Sabolić, Hermann Koepsell
Publikováno v:
ACS Omega, Vol 5, Iss 45, Pp 29127-29139 (2020)
Externí odkaz:
https://doaj.org/article/fc9265486a0d40f18c2b7d951c9e2cce
Desmoglein2 Regulates Claudin2 Expression by Sequestering PI-3-Kinase in Intestinal Epithelial Cells
Autor:
Natalie Burkard, Michael Meir, Felix Kannapin, Christoph Otto, Maximilian Petzke, Christoph-Thomas Germer, Jens Waschke, Nicolas Schlegel
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Inflammation-induced reduction of intestinal desmosomal cadherin Desmoglein 2 (Dsg2) is linked to changes of tight junctions (TJ) leading to impaired intestinal epithelial barrier (IEB) function by undefined mechanisms. We characterized the interplay
Externí odkaz:
https://doaj.org/article/1098f45c6ba440338f7f3a796c17e094
Autor:
Albert Busch, Jessica Pauli, Greg Winski, Sonja Bleichert, Ekaterina Chernogubova, Susanne Metschl, Hanna Winter, Matthias Trenner, Armin Wiegering, Christoph Otto, Johannes Fischer, Judith Reiser, Julia Werner, Joy Roy, Christine Brostjan, Christoph Knappich, Hans-Henning Eckstein, Valentina Paloschi, Lars Maegdefessel
Publikováno v:
JCI Insight, Vol 6, Iss 15 (2021)
Abdominal aortic aneurysm (AAA) is a disease with high morbidity and mortality, especially when ruptured. The rationale of this study was to evaluate the repurposing of lenvatinib, a multi–tyrosine kinase inhibitor, in limiting experimental AAA gro
Externí odkaz:
https://doaj.org/article/aac1ee9249d0448ab8daa9aa9135c5d1