Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Christoph N. Schlaffner"'
Autor:
Kathrin Wenger, Arthur Viode, Christoph N. Schlaffner, Patrick van Zalm, Long Cheng, Tammy Dellovade, Xavier Langlois, Anthony Bannon, Rui Chang, Theresa R. Connors, Derek Oakley, Bernhard Renard, Juri Rappsilber, Bradley Hyman, Hanno Steen, Judith A. Steen
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-15 (2023)
Abstract Background Mouse models that overexpress human mutant Tau (P301S and P301L) are commonly used in preclinical studies of Alzheimer’s Disease (AD) and while several drugs showed therapeutic effects in these mice, they were ineffective in hum
Externí odkaz:
https://doaj.org/article/0d7d9b70fb6e432d8c9dc6d0e97c6577
Autor:
Kimino Fujimura, Amanda J. Guise, Tojo Nakayama, Christoph N. Schlaffner, Anais Meziani, Mukesh Kumar, Long Cheng, Dylan J. Vaughan, Andrew Kodani, Simon Van Haren, Kenneth Parker, Ofer Levy, Ann F. Durbin, Irene Bosch, Lee Gehrke, Hanno Steen, Ganeshwaran H. Mochida, Judith A. Steen
Publikováno v:
iScience, Vol 26, Iss 7, Pp 106909- (2023)
Summary: Characterizing perturbation of molecular pathways in congenital Zika virus (ZIKV) infection is critical for improved therapeutic approaches. Leveraging integrative systems biology, proteomics, and RNA-seq, we analyzed embryonic brain tissues
Externí odkaz:
https://doaj.org/article/51cd38694972434695fcef207fb0e48f
Autor:
Christoph N Schlaffner, Konstantin Kahnert, Jan Muntel, Ruchi Chauhan, Bernhard Y Renard, Judith A Steen, Hanno Steen
Publikováno v:
eLife, Vol 9 (2020)
Improvements in LC-MS/MS methods and technology have enabled the identification of thousands of modified peptides in a single experiment. However, protein regulation by post-translational modifications (PTMs) is not binary, making methods to quantify
Externí odkaz:
https://doaj.org/article/342bbf4e9d90490a8302c3cd7ce97b8f
Autor:
Patrick van Zalm, Arthur Viodé, Kinga Smolen, Benoit Fatou, Arash Nemati Hayati, Christoph N. Schlaffner, Ofer Levy, Judith Steen, Hanno Steen
Publikováno v:
Journal of Proteome Research, 21(11), 2810-2814. American Chemical Society
Combining robust proteomics instrumentation with high-throughput enabling liquid chromatography (LC) systems (e.g., timsTOF Pro and the Evosep One system, respectively) enabled mapping the proteomes of 1000s of samples. Fragpipe is one of the few com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::818f66bb4e0f192359cbb6aac35b8ec6
https://pubmed.ncbi.nlm.nih.gov/36201825
https://pubmed.ncbi.nlm.nih.gov/36201825
Autor:
Kathrin Wenger, Arthur Viode, Christoph N. Schlaffner, Patrick van Zalm, Long Cheng, Tammy Dellovade, Xavier Langlois, Anthony Bannon, Theresa R. Connors, Derek Oakley, Bernhard Renard, Juri Rappsilber, Bradley Hyman, Hanno Steen, Judith Steen
Background: Mouse models that overexpress human mutant Tau (P301S and P301L) are commonly used in preclinical studies of Alzheimer’s Disease (AD) and while several drugs showed therapeutic effects in these mice, they were ineffective in humans. Thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d04f2e6a95d01dc81b248d4187f4f39
https://doi.org/10.21203/rs.3.rs-2056948/v1
https://doi.org/10.21203/rs.3.rs-2056948/v1
Autor:
Tue Bjerg Bennike, Kate Templeton, Kimino Fujimura, Melena D. Bellin, Saima Ahmed, Christoph N. Schlaffner, Rohit Arora, Zobeida Cruz-Monserrate, Ramy Arnaout, Gregory J. Beilman, Amit S. Grover, Darwin L. Conwell, Hanno Steen
Publikováno v:
Bennike, T B, Templeton, K, Fujimura, K, Bellin, M D, Ahmed, S, Schlaffner, C N, Arora, R, Cruz-Monserrate, Z, Arnaout, R, Beilman, G J, Groverc, A S, Conwell, D L & Steen, H 2022, ' Urine Proteomics Reveals Sex-Specific Response to Total Pancreatectomy with Islet Autotransplantation ', Pancreas, vol. 51, no. 5, pp. 435-444 . https://doi.org/10.1097/MPA.0000000000002063
Objectives: Total pancreatectomy with islet autotransplantation (TPIAT) is a surgical option for refractory chronic pancreatitis-related pain. Despite the known clinical implications of TPIAT, the molecular effects remain poorly investigated. We perf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73eece583777bca60674deb44931a9ee
https://vbn.aau.dk/da/publications/a125b3c6-38f9-4690-bb32-64ffecd2bdf1
https://vbn.aau.dk/da/publications/a125b3c6-38f9-4690-bb32-64ffecd2bdf1
Autor:
Kenneth S. Kosik, Shuko Takeda, Simon Dujardin, Bruce L. Miller, William W. Seeley, Hanno Steen, Pieter Beerepoot, Lea T. Grinberg, Sabina Berretta, Waltraud Mair, Long Cheng, Peter Davies, Bradley T. Hyman, Melissa S. Rotunno, Christoph N. Schlaffner, Hendrik Wesseling, Judith A. Steen, Shaojun Tang, Jan Muntel, Benoit Fatou, Mukesh Kumar, Amanda J. Guise, John C. Hedreen
Publikováno v:
Cell, vol 183, iss 6
Cell
Cell
To elucidate the role of Tau isoforms and post-translational modification (PTM) stoichiometry in Alzheimer's disease (AD), we generated a high-resolution quantitative proteomics map of 95 PTMs on multiple isoforms of Tau isolated from postmortem huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::832d36eeb5bf7b69718acb852e7afa3b
https://escholarship.org/uc/item/3qm9841c
https://escholarship.org/uc/item/3qm9841c
Autor:
Ruchi Chauhan, Jan Muntel, Christoph N Schlaffner, Konstantin Kahnert, Bernhard Y. Renard, Hanno Steen, Judith A. Steen
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Improvements in LC-MS/MS methods and technology have enabled the identification of thousands of modified peptides in a single experiment. However, protein regulation by post-translational modifications (PTMs) is not binary, making methods to quantify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7780ecdfe202d4d7ad6f15e0ecec2913
http://europepmc.org/articles/PMC7721442
http://europepmc.org/articles/PMC7721442
Author response: FLEXIQuant-LF to quantify protein modification extent in label-free proteomics data
Autor:
Bernhard Y. Renard, Judith A. Steen, Jan Muntel, Christoph N Schlaffner, Konstantin Kahnert, Ruchi Chauhan, Hanno Steen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1827332eeb8de9c35fb3df602ea97d9c
https://doi.org/10.7554/elife.58783.sa2
https://doi.org/10.7554/elife.58783.sa2
Autor:
Ruchi Chauhan, Hanno Steen, Jan Muntel, Bernhard Y. Renard, Christoph N Schlaffner, Konstantin Kahnert, Judith A. Steen
Improvements in LC-MS/MS methods and technology have enabled the identification of thousands of modified peptides in a single experiment. However, protein regulation by post-translational modifications (PTMs) is not binary, making methods to quantify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d88d8346b4d1ac41c4b08471e19b790a