50 years on and still very much alive: ‘Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics’

Autor: Christoph Nössing, Kevin M. Ryan

Publikováno v: British Journal of Cancer. 128:426-431

Cell death is part of the lifecycle of every multicellular organism. Nineteenth-century pathologists already recognised that organised forms of cell death must exist to explain the demise and turnover of cells during metamorphosis (of insects), embry

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::96d6eab4e8532a2b29f9729ce2af5514
https://doi.org/10.1038/s41416-022-02020-0

Autophagy suppresses the formation of hepatocyte-derived cancer-initiating ductular progenitor cells in the liver

Autor: Barbara Zunino, Valentin J.A. Barthet, Martina Brucoli, Christos Kiourtis, James O'Prey, Stephanie May, Kevin M. Ryan, Jaclyn S. Long, Marcus J. G. W. Ladds, Christoph Nössing, Alice D. Baudot, Miryam Müller, Thomas G. Bird, Colin Nixon

Publikováno v: Barthet, V J A, Brucoli, M, Ladds, M J G W, Nossing, C, Kiourtis, C, Baudot, A, O'Prey, J, Zunino, B, Müller, M, May, S, Nixon, C, Long, J S, Bird, T G & Ryan, K M 2021, ' Autophagy suppresses the formation of hepatocyte-derived cancer-initiating ductular progenitor cells in the liver ', Science Advances . https://doi.org/10.1126/sciadv.abf9141
Science Advances

Autophagy represses YAP/TAZ-dependent hepatocyte dedifferentiation into liver progenitor cells to prevent tumorigenesis.
Hepatocellular carcinoma (HCC) is driven by repeated rounds of inflammation, leading to fibrosis, cirrhosis, and, ultimately

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::066e61e3989c4c8c82a7f7473d74f3bf
https://eprints.gla.ac.uk/238882/1/238882.pdf