Výsledky vyhledávání - "Christoph Metzendorf"

Akademický článek

The S-palmitoylome and DHHC-PAT interactome of Drosophila melanogaster S2R+ cells indicate a high degree of conservation to mammalian palmitoylomes.

Autor: Elena Porcellato, Juan Carlos González-Sánchez, Constantin Ahlmann-Eltze, Mahmoud Ali Elsakka, Itamar Shapira, Jürgen Fritsch, Juan Antonio Navarro, Simon Anders, Robert B Russell, Felix T Wieland, Christoph Metzendorf

Publikováno v: PLoS ONE, Vol 17, Iss 8, p e0261543 (2022)

Protein S-palmitoylation, the addition of a long-chain fatty acid to target proteins, is among the most frequent reversible protein modifications in Metazoa, affecting subcellular protein localization, trafficking and protein-protein interactions. S-

Externí odkaz: https://doaj.org/article/7c78ced4ce3245f1a07ff8f1e3ea7f8a

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Akademický článek

Cell-specific expression of Hfe determines the outcome of Salmonella enterica serovar Typhimurium infection in mice

Autor: Manfred Nairz, Christoph Metzendorf, Maja Vujic-Spasic, Anna-Maria Mitterstiller, Andrea Schroll, David Haschka, Alexander Hoffmann, Laura von Raffay, Richard Sparla, Christian W. Huck, Heribert Talasz, Patrizia L. Moser, Martina U. Muckenthaler, Günter Weiss

Publikováno v: Haematologica, Vol 106, Iss 12 (2020)

Mutations in HFE cause hereditary hemochromatosis type I hallmarked by increased iron absorption, iron accumulation in hepatocytes and iron deficiency in myeloid cells. HFE encodes an MHC-I like molecule, but its function in immune responses to infec

Externí odkaz: https://doaj.org/article/df5015198e9842daac67016118062967

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Akademický článek

Hormonally Induced Hepatocellular Carcinoma in Diabetic Wild Type and Carbohydrate Responsive Element Binding Protein Knockout Mice

Autor: Vincent Nuernberger, Sharif Mortoga, Christoph Metzendorf, Christian Burkert, Katrina Ehricke, Elisa Knuth, Jenny Zimmer, Stephan Singer, Neetika Nath, Majedul Karim, Mohd Yasser, Diego F. Calvisi, Frank Dombrowski, Silvia Ribback

Publikováno v: Cells, Vol 10, Iss 10, p 2787 (2021)

Objective: In the rat, the pancreatic islet transplantation model is an established method to induce hepatocellular carcinomas (HCC), due to insulin-mediated metabolic and molecular alterations like increased glycolysis and de novo lipogenesis and th

Externí odkaz: https://doaj.org/article/9a3570447dce481f80290783ce224139

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Akademický článek

Acute loss of the hepatic endo-lysosomal system in vivo causes compensatory changes in iron homeostasis

Autor: Christoph Metzendorf, Anja Zeigerer, Sarah Seifert, Richard Sparla, Bahar Najafi, François Canonne-Hergaux, Marino Zerial, Martina U. Muckenthaler

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)

Abstract Liver cells communicate with the extracellular environment to take up nutrients via endocytosis. Iron uptake is essential for metabolic activities and cell homeostasis. Here, we investigated the role of the endocytic system for maintaining i

Externí odkaz: https://doaj.org/article/02702bebeda441eca74b0906443eaff0

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Akademický článek

Transcriptomic and Proteomic Analysis of Clear Cell Foci (CCF) in the Human Non-Cirrhotic Liver Identifies Several Differentially Expressed Genes and Proteins with Functions in Cancer Cell Biology and Glycogen Metabolism

Autor: Christoph Metzendorf, Katharina Wineberger, Jenny Rausch, Antonio Cigliano, Kristin Peters, Baodong Sun, Daniela Mennerich, Thomas Kietzmann, Diego F. Calvisi, Frank Dombrowski, Silvia Ribback

Publikováno v: Molecules, Vol 25, Iss 18, p 4141 (2020)

Clear cell foci (CCF) of the liver are considered to be pre-neoplastic lesions of hepatocellular adenomas and carcinomas. They are hallmarked by glycogen overload and activation of AKT (v-akt murine thymoma viral oncogene homolog)/mTOR (mammalian tar

Externí odkaz: https://doaj.org/article/644c18e3ec37466483a22f2954f856a0

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Akademický článek

Modelling Systemic Iron Regulation during Dietary Iron Overload and Acute Inflammation: Role of Hepcidin-Independent Mechanisms.

Autor: Mihaela Enculescu, Christoph Metzendorf, Richard Sparla, Maximilian Hahnel, Johannes Bode, Martina U Muckenthaler, Stefan Legewie

Publikováno v: PLoS Computational Biology, Vol 13, Iss 1, p e1005322 (2017)

Systemic iron levels must be maintained in physiological concentrations to prevent diseases associated with iron deficiency or iron overload. A key role in this process plays ferroportin, the only known mammalian transmembrane iron exporter, which re

Externí odkaz: https://doaj.org/article/9cbcb652b269424cad432e7491897bbd

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