Cytoplasmic poly-GA aggregates impair nuclear import of TDP-43 in C9orf72 ALS/FTLD

Autor: Dieter Edbauer, Bahram Khosravi, Dorothee Dormann, Helena Ederle, Christoph Möhl, Martin H. Schludi, Meike Michaelsen, Hannelore Hartmann, Stephanie May

Publikováno v: Human Molecular Genetics
Human molecular genetics 26(4), ddw432 (2016). doi:10.1093/hmg/ddw432

A repeat expansion in the non-coding region of C9orf72 gene is the most common mutation causing frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). Sense and antisense transcripts are translated into aggregating dipeptid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e42f8f3c60e67b5398c850f2e78d39a
http://europepmc.org/articles/PMC5409121

Analyzing Synaptic Modulation of Drosophila melanogaster Photoreceptors after Exposure to Prolonged Light

Autor: Atsushi Sugie, Takashi Suzuki, Gaia Tavosanis, Christoph Möhl, Satoko Hakeda-Suzuki, Hideaki Matsui

Publikováno v: Journal of Visualized Experiments.

The nervous system has the remarkable ability to adapt and respond to various stimuli. This neural adjustment is largely achieved through plasticity at the synaptic level. The Active Zone (AZ) is the region at the presynaptic membrane that mediates n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::219b0a4a86c4bf9b247b1e6d985b6b57
https://doi.org/10.3791/55176

tFRAP: A FRAP-Based Technique to Monitor Protein Translation in Living Cells

Autor: Ireen König, Stephanie Weber, Christoph Möhl, Sybille Krau, Verena Pesch, Rohit Nalavade, Manuel Schölling, Nadine Griesche

Publikováno v: Journal of Analytical & Bioanalytical Techniques.

Traditionally, studies on protein translation rely on systems, in which cells have been lysed prior determination of levels of the protein of interest. However, these assays do not reflect the protein synthesis in living cells in real time, but analy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d317a381121cd853c0db9e5f443f7df6
https://doi.org/10.4172/2155-9872.1000390

Quantitative mapping of averaged focal adhesion dynamics in migrating cells by shape normalization

Autor: Christoph Möhl, Norbert Kirchgessner, Rudolf Merkel, Bernd Hoffmann, Claudia Schäfer

Publikováno v: Journal of cell science 125, 155-165 (2012). doi:10.1242/jcs.090746
Journal of cell science 125(1), 155-165 (2012). doi:10.1242/jcs.090746

The spatially ordered formation and disassembly of focal adhesions is a basic requirement for effective cell locomotion. Because focal adhesions couple the contractile actin–myosin network to the substrate, their distribution determines the pattern

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f59ef04083b0029fa426f6b202aade70
https://doi.org/10.1242/jcs.090746

Regulation of NK cell trafficking by CD81

Autor: Jacob Nattermann, Claudia Zwank, Benjamin Krämer, Tilman Sauerbruch, Agathe Hartmann, Hans-Dieter Nischalke, D. Schulte, Annabelle Vogt, Christian Körner, J Söhne, Martin Coenen, Martin Hennenberg, Bettina Langhans, M. Michalk, Christoph Möhl, Ulrich Spengler

Publikováno v: European Journal of Immunology. 39:3447-3458

NK cells, a heterogeneous sub-population of lymphocytes, are critically involved in the regulation of both innate and adaptive immune responses in humans. Besides their participation in the control of tumors and viral infections, they also regulate i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::379d6e2932ad7dc7ab64d63824616984
https://doi.org/10.1002/eji.200939234