BNT162b vaccines protect rhesus macaques from SARS-CoV-2

Autor: Bernadette Jesionek, Charles Tan, Christoph Kröner, Jennifer Obregon, Stephanie Hein, Kathleen M. Brasky, Andreas Kuhn, Leyla Fischer, Guy Singh, Diana Schneider, Kathrin U. Jansen, Jane Fontenot, Seungil Han, Michal Gazi, Corinna Rosenbaum, Ingrid L. Scully, Pei Yong Shi, Parag Sahasrabudhe, Stefanie A. Krumm, Hanna Junginger, Camila R. Fontes-Garfias, Julia Schlereth, Bonny Gaby Lui, Mathias Vormehr, Andre P. Heinen, Alptekin Güler, Stephanie Fesser, Sarah C. Dany, Ellene H. Mashalidis, Danka Pavliakova, Shambhunath Choudhary, Mohan S. Maddur, Petra Adams-Quack, Yvonne Feuchter, Matthew C. Griffor, Ferdia Bates, Ramón de la Caridad Güimil Garcia, Tara Ciolino, Özlem Türeci, Stefan Schille, Kena A. Swanson, Kerstin C. Walzer, Alexander Muik, Jakob Loschko, Ayuko Ota-Setlik, Nicole L. Nedoma, Lena M. Kranz, Tompkins Kristin Rachael, Thorsten Klamp, Ugur Sahin, Ann Kathrin Wallisch, Warren Kalina, Olga Gonzalez, Fulvia Vascotto, Philip R. Dormitzer, Ye Che, Kendra J. Alfson, Ricardo Carrion, Thomas Ziegenhals, Shannan Hall-Ursone, Rani S. Sellers, Thomas Hiller, Isis Kanevsky, Matthew R. Gutman, Michael W. Pride, Stephanie Erbar, Bianca Sänger, Deepak Kaushal, Journey Cole, David Eisel, Andreas A.H. Su, Joshua A. Lees, Annette B. Vogel, Arianne Plaschke

Publikováno v: Nature

A safe and effective vaccine against COVID-19 is urgently needed in quantities that are sufficient to immunize large populations. Here we report the preclinical development of two vaccine candidates (BNT162b1 and BNT162b2) that contain nucleoside-mod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3903ab0fb32c26fb7ed5bc8fa70296ed
https://doi.org/10.1038/s41586-021-03275-y

Binding Cofactors with Triplex-Based DNA Motifs

Autor: Christoph Kröner, Wenjing Liu, Clemens Richert, Anja Göckel

Publikováno v: Chemistry - A European Journal. 19:15879-15887

Cofactors are pivotal compounds for the cell and many biotechnological processes. It is therefore interesting to ask how well cofactors can be bound by oligonucleotides designed not to convert but to store and release these biomolecules. Here we show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07e6f93ea98e66efb170a11bfab8a61e
https://doi.org/10.1002/chem.201303098

Nucleotide storage and incorporation via chemical primer extension

Autor: Manuel Röthlingshöfer, Andreas Kaiser, Eric Kervio, Christoph Kröner, Tanja Lommel, Clemens Richert, Sebastian Spies

Publikováno v: Collection Symposium Series.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d3cf611098f93d8c572a1d58e669e08b
https://doi.org/10.1135/css201112236