Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Christoph Korpus"'
Publikováno v:
Journal of Chromatography B. 1179:122848
The purification of monoclonal antibodies and Fc fusion proteins consist of several unit operations operated commonly as a platform approach, starting with Protein A chromatography. The first capture step, the following low pH virus inactivation, and
Autor:
Christoph Korpus, Wolfgang Friess
Publikováno v:
Journal of Pharmaceutical Sciences. 106:2077-2087
Freeze-drying process design is a challenging task that necessitates a profound understanding of the complex interrelation among critical process parameters (e.g., shelf temperature and chamber pressure), heat transfer characteristics of the involved
Autor:
Christoph Korpus, Wolfgang Friess
Publikováno v:
Journal of Pharmaceutical Sciences. 106:1092-1101
For freeze-drying in dual-chamber cartridges, a holder device to enable handling and safe positioning in the freeze-dryer is necessary. The aim of this study was to analyze 4 different types of holder devices and to define the best system based on en
Publikováno v:
Journal of Pharmaceutical Sciences. 105:3304-3313
The aim of this study was to determine the heat transfer characteristics of an optimized flexible holder device, using Tunable Diode Laser Absorption Spectroscopy, the Pressure Rise Test, and the gravimetric procedure. Two different controlled nuclea
Publikováno v:
Journal of Pharmaceutical Sciences. 104:1750-1758
Freeze-drying essentially requires knowledge about the heat and mass transfer characteristics to assure product quality. Whereas this understanding has been created for freeze-drying in vials, only limited information is available for state-of-the-ar