Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Christoph Klenk"'
Autor:
Christoph Klenk, Maria Scrivens, Anina Niederer, Shuying Shi, Loretta Mueller, Elaine Gersz, Maurice Zauderer, Ernest S. Smith, Ralf Strohner, Andreas Plückthun
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
G protein-coupled receptors are a major class of drug targets. Here, the authors develop a method whereby their biophysical and functional properties can be altered through directed evolution in mammalian cells, leading to variants exhibiting feature
Externí odkaz:
https://doaj.org/article/b76be3cffcda479f9ff2db12a5dfd09a
Autor:
Mattia Deluigi, Lena Morstein, Matthias Schuster, Christoph Klenk, Lisa Merklinger, Riley R. Cridge, Lazarus A. de Zhang, Alexander Klipp, Santiago Vacca, Tasneem M. Vaid, Peer R. E. Mittl, Pascal Egloff, Stefanie A. Eberle, Oliver Zerbe, David K. Chalmers, Daniel J. Scott, Andreas Plückthun
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
This study reports the X-ray structure of the α1B-adrenergic G protein-coupled receptor bound to an inverse agonist, and unveils key determinants of subtype-selective ligand binding that may help the design of aminergic drugs with fewer side-effects
Externí odkaz:
https://doaj.org/article/9eae3c81d8e34aff9e67ac17ad3df5fe
Proteolytic Cleavage of the Extracellular Domain Affects Signaling of Parathyroid Hormone 1 Receptor
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Parathyroid hormone 1 receptor (PTH1R) is a member of the class B family of G protein-coupled receptors, which are characterized by a large extracellular domain required for ligand binding. We have previously shown that the extracellular domain of PT
Externí odkaz:
https://doaj.org/article/935fb72434e34706bb014467e30863b4
Autor:
Jendrik Schöppe, Janosch Ehrenmann, Christoph Klenk, Prakash Rucktooa, Marco Schütz, Andrew S. Doré, Andreas Plückthun
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Neurokinin receptors are G protein-coupled receptors. Here the authors present three crystal structures of the neurokinin 1 receptor (NK1R) in complex with small-molecule antagonists including aprepitant and netupitant and observe that these clinical
Externí odkaz:
https://doaj.org/article/6c1b5d05ad4143f2afd6b9134b37d802
Publikováno v:
Molecules, Vol 26, Iss 5, p 1465 (2021)
Membrane proteins such as G protein-coupled receptors (GPCRs) exert fundamental biological functions and are involved in a multitude of physiological responses, making these receptors ideal drug targets. Drug discovery programs targeting GPCRs have b
Externí odkaz:
https://doaj.org/article/32bcdb1efb6c4f54a379fb8c496ae1a0
Autor:
Christoph Klenk
Publikováno v:
Klimaneutralität in der Industrie ISBN: 9783662661246
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c19a8b1f9bb398b86c32948aa874721
https://doi.org/10.1007/978-3-662-66125-3_18
https://doi.org/10.1007/978-3-662-66125-3_18
Autor:
Christoph Klenk, Maria Scrivens, Anina Niederer, Shuying Shi, Loretta Mueller, Elaine Gersz, Maurice Zauderer, Ernest Smith, Ralf Strohner, Andreas Plückthun
Low stability and poor expression levels are inherent in many G protein-coupled receptors, hindering structural and biophysical analyses. Directed evolution in bacterial or yeast display systems has been successfully used to overcome both limitations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cdab7895d213120ed492900825cbe37
https://doi.org/10.1101/2022.10.17.512578
https://doi.org/10.1101/2022.10.17.512578
Proteolytic cleavage of the extracellular domain affects signaling of parathyroid hormone receptor 1
Parathyroid hormone 1 receptor (PTH1R) is a member of the class B family of G protein-coupled receptors, which are characterized by a large extracellular domain required for ligand binding. We have previously shown that the extracellular domain of PT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f2356877fc5344cefb2e2889385a7df
https://doi.org/10.1101/2021.12.16.472984
https://doi.org/10.1101/2021.12.16.472984
Autor:
Mattia, Deluigi, Lena, Morstein, Matthias, Schuster, Christoph, Klenk, Lisa, Merklinger, Riley R, Cridge, Lazarus A, de Zhang, Alexander, Klipp, Santiago, Vacca, Tasneem M, Vaid, Peer R E, Mittl, Pascal, Egloff, Stefanie A, Eberle, Oliver, Zerbe, David K, Chalmers, Daniel J, Scott, Andreas, Plückthun
Publikováno v:
Nature Communications
α-adrenergic receptors (αARs) are G protein-coupled receptors that regulate vital functions of the cardiovascular and nervous systems. The therapeutic potential of αARs, however, is largely unexploited and hampered by the scarcity of subtype-selec
Publikováno v:
Molecules
Molecules, Vol 26, Iss 1465, p 1465 (2021)
Molecules, Vol 26, Iss 1465, p 1465 (2021)
Membrane proteins such as G protein-coupled receptors (GPCRs) exert fundamental biological functions and are involved in a multitude of physiological responses, making these receptors ideal drug targets. Drug discovery programs targeting GPCRs have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::150d7a9da23de08d1c5007ceb076b0e6
https://doi.org/10.5167/uzh-210190
https://doi.org/10.5167/uzh-210190