Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Christoph Kellendonk"'
Autor:
Marie A. Labouesse, Arturo Torres-Herraez, Muhammad O. Chohan, Joseph M. Villarin, Julia Greenwald, Xiaoxiao Sun, Mysarah Zahran, Alice Tang, Sherry Lam, Jeremy Veenstra-VanderWeele, Clay O. Lacefield, Jordi Bonaventura, Michael Michaelides, C. Savio Chan, Ofer Yizhar, Christoph Kellendonk
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract In the classical model of the basal ganglia, direct pathway striatal projection neurons (dSPNs) send projections to the substantia nigra (SNr) and entopeduncular nucleus to regulate motor function. Recent studies have re-established that dSP
Externí odkaz:
https://doaj.org/article/81d980c17c3448e59ac7e2551e221f37
Autor:
Sarah E Canetta, Emma S Holt, Laura J Benoit, Eric Teboul, Gabriella M Sahyoun, R Todd Ogden, Alexander Z Harris, Christoph Kellendonk
Publikováno v:
eLife, Vol 11 (2022)
In their seminal findings, Hubel and Wiesel identified sensitive periods in which experience can exert lasting effects on adult visual cortical functioning and behavior via transient changes in neuronal activity during development. Whether comparable
Externí odkaz:
https://doaj.org/article/6ec9213bdee04c83880c62f557c7c5bd
Autor:
Job O. de Jong, Ceyda Llapashtica, Matthieu Genestine, Kevin Strauss, Frank Provenzano, Yan Sun, Huixiang Zhu, Giuseppe P. Cortese, Francesco Brundu, Karlla W. Brigatti, Barbara Corneo, Bianca Migliori, Raju Tomer, Steven A. Kushner, Christoph Kellendonk, Jonathan A. Javitch, Bin Xu, Sander Markx
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Mutations in CNTNAP2 have been associated with a syndromic form of Autism Spectrum Disorder. Here the authors show that forebrain organoids generated from induced pluripotent stem cells of patients with a syndromic form of ASD with a homozygous trunc
Externí odkaz:
https://doaj.org/article/23d0c5b97fef4d90b66fccf00b3134ee
Autor:
Kelly M Martyniuk, Arturo Torres-Herraez, Daniel C Lowes, Marcelo Rubinstein, Marie A Labouesse, Christoph Kellendonk
Publikováno v:
eLife, Vol 11 (2022)
In the striatum, acetylcholine (ACh) neuron activity is modulated co-incident with dopamine (DA) release in response to unpredicted rewards and reward-predicting cues and both neuromodulators are thought to regulate each other. While this co-regulati
Externí odkaz:
https://doaj.org/article/c1da0dccdc9e4a8580337b1bf977c1fc
Autor:
Emma Puighermanal, Laia Castell, Anna Esteve-Codina, Su Melser, Konstantin Kaganovsky, Charleine Zussy, Jihane Boubaker-Vitre, Marta Gut, Stephanie Rialle, Christoph Kellendonk, Elisenda Sanz, Albert Quintana, Giovanni Marsicano, Miquel Martin, Marcelo Rubinstein, Jean-Antoine Girault, Jun B. Ding, Emmanuel Valjent
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Striatal dopaminoceptive neurons are molecularly and functionally heterogeneous. Here, the authors provide the translatome of D2R striatal neurons and identified hundreds of region specific molecular markers as well as testing their resource to shed
Externí odkaz:
https://doaj.org/article/d4d48f37c7d94541a98488897d3e9b83
Autor:
Eduardo F. Gallo, Jozsef Meszaros, Jeremy D. Sherman, Muhammad O. Chohan, Eric Teboul, Claire S. Choi, Holly Moore, Jonathan A. Javitch, Christoph Kellendonk
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Dopamine D2 receptor activity in the nucleus accumbens is associated with regulation of motivated responding. Here the authors show that overexpression of D2 receptors specifically in ventral striatal projection neurons leads to an increase in the wi
Externí odkaz:
https://doaj.org/article/9716d06b79b041318d69d2b9867976d1
Autor:
Alvaro L. Garcia-Garcia, Qingyuan Meng, Sarah Canetta, Alain M. Gardier, Bruno P. Guiard, Christoph Kellendonk, Alex Dranovsky, E. David Leonardo
Publikováno v:
Cell Reports, Vol 18, Iss 5, Pp 1144-1156 (2017)
Lifelong homeostatic setpoints for mood-related behaviors emerge during adolescence. Serotonin (5-HT) plays an important role in refining the formation of brain circuits during sensitive developmental periods. In rodents, the role of 5-HT1A receptors
Externí odkaz:
https://doaj.org/article/fc81a5da2f2d4b5faebd77c6092af7d1
Autor:
Jozsef Meszaros, Timothy Cheung, Maya M Erler, Un Jung Kang, Dalibor Sames, Christoph Kellendonk, David Sulzer
Publikováno v:
eLife, Vol 7 (2018)
Dopamine neurotransmission is suspected to play important physiological roles in multiple sparsely innervated brain nuclei, but there has not been a means to measure synaptic dopamine release in such regions. The globus pallidus externa (GPe) is a ma
Externí odkaz:
https://doaj.org/article/5586b987088e4e8283cc4914fbf90471
Autor:
Marie Labouesse, Arturo Torres-Herraez, Muhammad Chohan, Joseph Villarin, Julia Greenwald, Xiaoxiao Sun, Mysarah Zahran, Alice Tang, Sherry Lam, Jeremy Veenstra-VanderWeele, Clay Lacefield, Jordi Bonaventura, Michael Michaelides, Savio Chan, Ofer Yizhar, Christoph Kellendonk
In the classical model of the basal ganglia, direct pathway striatal projection neurons (dSPNs) send projections to the substantia nigra (SNr) and entopeduncular nucleus to regulate motor function. Recent studies have re-established that dSPNs also p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::616089ede81b09b0cffd0c5cfbea02f9
https://doi.org/10.21203/rs.3.rs-2524816/v1
https://doi.org/10.21203/rs.3.rs-2524816/v1
Autor:
Joseph M. Villarin, Eric Teboul, Peter D. Balsam, Christoph Kellendonk, Jonathan A. Javitch, Julia E. Greenwald, Kelly M. Martyniuk, Eduardo F. Gallo, Yulong Li, Jenna Yeisley
Publikováno v:
Molecular Psychiatry. 27:1502-1514
Cholinergic interneurons (CINs) in the striatum respond to salient stimuli with a multiphasic response, including a pause, in neuronal activity. Slice-physiology experiments have shown the importance of dopamine D2 receptors (D2Rs) in regulating CIN