Výsledky vyhledávání - "Christoph Kalis"

Akademický článek

TLR9-dependent and independent pathways drive activation of the immune system by Propionibacterium acnes.

Autor: Sandrine Tchaptchet, Marina Gumenscheimer, Christoph Kalis, Nikolaus Freudenberg, Christoph Hölscher, Carsten J Kirschning, Marinus Lamers, Chris Galanos, Marina A Freudenberg

Publikováno v: PLoS ONE, Vol 7, Iss 6, p e39155 (2012)

Propionibacterium acnes is usually a relatively harmless commensal. However, under certain, poorly understood conditions it is implicated in the etiology of specific inflammatory diseases. In mice, P. acnes exhibits strong immunomodulatory activity l

Externí odkaz: https://doaj.org/article/fd2a8b577e9444a89e210b1f6807adc9

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OP0250 A randomised, double-blind study to assess the safety, tolerability and preliminary efficacy of leniolisib (CDZ173) in patients with primary sjÖgren’s syndrome

Autor: Maciej Cabanski, Marie-Anne Valentin, S. De Buck, Anke Hasselberg, Thomas Dörner, U. Laessing, Margit Zeher, Christoph Burkhart, Christoph Kalis, Pál Gergely, F. Chaperon, S. Ma

Publikováno v: FRIDAY, 15 JUNE 2018.

Background Primary Sjogren’s syndrome (pSS) is a systemic and progressive autoimmune disease characterised by lymphoid infiltration and progressive alteration of exocrine glands secretory function. Ectopic germinal center-like structures harbour pl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b02defb4d1a97561632611010b314b17
https://doi.org/10.1136/annrheumdis-2018-eular.3111

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Effective 'activated PI3Kδ syndrome'–targeted therapy with the PI3Kδ inhibitor leniolisib

Publikováno v: Blood, 130(21), 2307-2316. American Society of Hematology

Pathogenic gain-of-function variants in the genes encoding phosphoinositide 3-kinase δ (PI3Kδ) lead to accumulation of transitional B cells and senescent T cells, lymphadenopathy, and immune deficiency (activated PI3Kδ syndrome [APDS]). Knowing th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42ee11d7e47890c9ff26ab300ee6042f
https://europepmc.org/articles/PMC5701526/

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Safety and Efficacy of Long Term Suppression of PI3Kinase Pathway By Small Molecule PI3K-Delta Inhibitor, Leniolisib in Apds (Activated PI3Kδ Syndrome)

Autor: Birgitte Sloth, Gulbu Uzel, P. Martin van Hagen, Klaus Kucher, Les R. Folio, V. Koneti Rao, Sharon Webster, H. Michael Do, Stefan De Buck, Anke Hasselberg, Christoph Burkhart, Christoph Kalis, Virgil A. S. H. Dalm, Maciej Cabanski, Marie-Anne Valentin, Anna Sediva

Publikováno v: Blood. 132:3706-3706

Inherited gain-of-function mutations in PIK3CD encoding PI3Kδ (phosphoinositide 3-kinase delta) lead to accumulation of senescent T cells, lymphadenopathy, splenomegaly and immune-deficiency (Activated PI3Kδ Syndrome, APDS). Clinical manifestations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d155d821874d9b98b86d7f1fbe55bd47
https://doi.org/10.1182/blood-2018-99-113426

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Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel

Autor: Thomas Vogl, Verena Müller, Marc Schmidt, Sandrine Tchaptchet, Matthias Goebeler, Johannes Roth, Arne Skerra, Stefan F. Martin, Peter J. Nielsen, Marina A. Freudenberg, Chris Galanos, Simone Keck, Badrinarayanan Raghavan, György Fejer, Christoph Kalis

Publikováno v: Nature Immunology. 11:814-819

Allergies to nickel (Ni(2+)) are the most frequent cause of contact hypersensitivity (CHS) in industrialized countries. The efficient development of CHS requires both a T lymphocyte-specific signal and a proinflammatory signal. Here we show that Ni(2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61bfaddb40992b0fcdc93965db57b89f
https://doi.org/10.1038/ni.1919

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Stimulation of mast cells via FcɛR1 and TLR2: The type of ligand determines the outcome

Autor: Michael Huber, Chris Galanos, Gordon Grochowy, Wolfgang G. Bessler, Gerald Krystal, Fillip Port, Christoph Kalis, Marina A. Freudenberg, Kerstin Fehrenbach

Publikováno v: Molecular Immunology. 44:2087-2094

Little is known about the interplay between pathophysiological processes of allergy and infection, particularly with respect to mast cell (MC)-mediated responses. The presence and recognition of pathogen-associated molecular patterns (PAMPs) might ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b0c00c1656cf674735c3312413f67e0f
https://doi.org/10.1016/j.molimm.2006.09.011

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Infection of C57BL/10ScCr and C57BL/10ScNCr mice withLeishmania majorreveals a role for Toll-like receptor 4 in the control of parasite replication

Autor: Pascale Kropf, N. Freudenberg, Marina A. Freudenberg, Manuel Modolell, Chris Galanos, Ines Müller, Shanti Herath, Christoph Kalis

Publikováno v: Journal of Leukocyte Biology. 76:48-57

The innate immune system is essential for host defense; it senses the presence of potentially pathogenic-invading microorganisms, and the contribution of Toll-like receptors (TLRs) to this response is increasingly recognized. In the present study, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2884f4d5fdbea29b1d05fa5c8dad425
https://doi.org/10.1189/jlb.1003484

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Differential Contribution of Toll-Like Receptors 4 and 2 to the Cytokine Response toSalmonella entericaSerovar Typhimurium andStaphylococcus aureusin Mice

Autor: Emilio Jirillo, Vincenzo Mitolo, Annalisa Lembo, Hermann Wagner, Christoph Kalis, Marina A. Freudenberg, Chris Galanos, Carsten J. Kirschning

Publikováno v: Infection and Immunity. 71:6058-6062

The contribution of murine Toll-like receptors 2 and 4 (TLR2 and -4, respectively) to cytokine induction by heat-killed bacteria was analyzed in vitro and in vivo. Gram-negative bacteria induced cytokines primarily via TLR4; the contribution of TLR2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf355d08fe86cdbe74ff0cc052ab3ef
https://doi.org/10.1128/iai.71.10.6058-6062.2003

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Role of interferons in LPS hypersensitivity

Autor: Marina Gumenscheimer, Chris Galanos, Yolande Chvatchko, Marina A. Freudenberg, Christoph Kalis, Thomas Merlin

Publikováno v: Journal of Endotoxin Research. 9:308-312

The innate immune response to Gram-negative bacteria depends mainly on the ability of the host to respond to the LPS component. Consequently, the state of LPS sensitivity at the time of infection and the numbers of invading bacteria (i.e. the amounts

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fb3c713d651e94cc831385e0c4157a1
https://doi.org/10.1177/09680519030090050601

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Toll-like receptor 4 expression levels determine the degree of LPS-susceptibility in mice

Autor: Chris Galanos, Marina A. Freudenberg, Alexander Poltorak, Christoph Kalis, Annalisa Lembo, Benoît Kanzler

Publikováno v: European Journal of Immunology. 33:798-805

C57BL/10ScCr (Cr) mice carry a deletion of the Toll-like receptor 4 (tlr4) gene (i.e. they are tlr4(0/0)) and are thus refractory to LPS effects. Insertion of wild-type tlr4 transgene into the tlr4(0/0) Cr germ line endowed LPS susceptibility in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaa9eb490ca1e42c2e2e331accdf769c
https://doi.org/10.1002/eji.200323431

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