Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Christoph Kaether"'
Autor:
Patricia Franzka, Svenja Caren Schüler, Takfarinas Kentache, Robert Storm, Andrea Bock, Istvan Katona, Joachim Weis, Katrin Buder, Christoph Kaether, Christian A. Hübner
Publikováno v:
Biomedicines, Vol 11, Iss 1, p 146 (2023)
Proteins of the secretory pathway undergo glycosylation in the endoplasmic reticulum (ER) and the Golgi apparatus. Altered protein glycosylation can manifest in serious, sometimes fatal malfunctions. We recently showed that mutations in GDP-mannose p
Externí odkaz:
https://doaj.org/article/5f09ccc306114230a2dcd4d04682e370
Publikováno v:
Neurobiology of Disease, Vol 155, Iss , Pp 105400- (2021)
Mutations in the ER-network forming GTPase atlastin3 (ATL3) can cause axon degeneration of sensory neurons by not fully understood mechanisms. We here show that the hereditary sensory and autonomous neuropathy (HSAN)-causing ATL3 Y192C or P338R are e
Externí odkaz:
https://doaj.org/article/3216c1dd35794fba99cd858490d16657
Autor:
Karl Köhnlein, Nadine Urban, David Guerrero-Gómez, Holger Steinbrenner, Pavel Urbánek, Josephine Priebs, Philipp Koch, Christoph Kaether, Antonio Miranda-Vizuete, Lars-Oliver Klotz
Publikováno v:
Redox Biology, Vol 28, Iss , Pp - (2020)
Human selenium-binding protein 1 (SELENBP1) was originally identified as a protein binding selenium, most likely as selenite. SELENBP1 is associated with cellular redox and thiol homeostasis in several respects, including its established role as a me
Externí odkaz:
https://doaj.org/article/81369527dd3f45ca84991cf3cfbad8a7
Autor:
Hellen E. Ahrens, Judith Huettemeister, Manuel Schmidt, Christoph Kaether, Julia von Maltzahn
Publikováno v:
Skeletal Muscle, Vol 8, Iss 1, Pp 1-14 (2018)
Abstract Background Klotho is a well-known anti-aging hormone, which serves as a suppressor of aging through a variety of mechanisms. Aging of skeletal muscle is concomitant with a decrease in muscle stem cell function resulting in impaired regenerat
Externí odkaz:
https://doaj.org/article/424f0ac274564f9186109785fe5582d2
Autor:
Shiva Marthandan, Uwe Menzel, Steffen Priebe, Marco Groth, Reinhard Guthke, Matthias Platzer, Peter Hemmerich, Christoph Kaether, Stephan Diekmann
Publikováno v:
Biological Research, Vol 49, Iss 0, Pp 1-16
BACKGROUND: Cellular senescence is induced either internally, for example by replication exhaustion and cell division, or externally, for example by irradiation. In both cases, cellular damages accumulate which, if not successfully repaired, can resu
Externí odkaz:
https://doaj.org/article/f1613622128f45929a7c7b193a4ec3ad
Autor:
Hans-Dieter Arndt, Christoph Kaether, Benjamin Dietzek, Michael Duong, Patrick Then, Rainer Heintzmann, Fabian Dröge, Veselin Nasufovic
Publikováno v:
Organic & Biomolecular Chemistry. 19:574-578
An efficient synthesis for silicon-rhodamines was developed, enabling the preparation and evaluation of silicon-rhodamine isothiocyanate (SITC) as a novel tool for facile fluorescent labeling. Ease of use in conjugation to amino groups, high stabilit
Autor:
Domenico Di Fraia, Mihaela Anitei, Marie-Therese Mackmull, Luca Parca, Laura Behrendt, Amparo Andres-Pons, Darren Gilmour, Manuela Helmer Citterich, Christoph Kaether, Martin Beck, Alessandro Ori
Publikováno v:
Life Science Alliance, 5 (6)
Gene duplication enables the emergence of new functions by lowering the evolutionary pressure that is posed on the ancestral genes. Previous studies have highlighted the role of specific paralog genes during cell differentiation, for example, in chro
Autor:
Tina Rüdiger, George Yakoub, Christoph Kaether, Tangliang Li, Kanstantsin Siniuk, Ruiqing Lu, Murat Kirtay, Nadine Schneble, Zhong-Wei Zhou, Yi-Nan Jiang, Mingmei Ding, Ari Barzilai, Zhao-Qi Wang
Publikováno v:
Nucleic Acids Research
NBS1 is a critical component of the MRN (MRE11/RAD50/NBS1) complex, which regulates ATM- and ATR-mediated DNA damage response (DDR) pathways. Mutations in NBS1 cause the human genomic instability syndrome Nijmegen Breakage Syndrome (NBS), of which ne
Autor:
Christoph Kaether, Antonio Miranda-Vizuete, Lars-Oliver Klotz, David Guerrero-Gómez, Karl Köhnlein, Holger Steinbrenner, Nadine Urban
Publikováno v:
Current Nutraceuticals. 1:73-79
Background: The essential trace element and micronutrient selenium exerts most of its biological actions through incorporation into selenoproteins as selenocysteine. Two further types of Se-containing proteins exist, including those that have selenom
Autor:
Liana Marengo, Fred Armbrust, Caroline Schoenherr, Steffen E. Storck, Ulrich Schmitt, Silvia Zampar, Oliver Wirths, Hermann Altmeppen, Markus Glatzel, Christoph Kaether, Sascha Weggen, Christoph Becker-Pauly, Claus U. Pietrzik
Publikováno v:
Cellular and molecular life sciences, 79(3):168
β-Site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1) is the major described β-secretase to generate Aβ peptides in Alzheimer’s disease (AD). However, all therapeutic attempts to block BACE1 activity and to improve AD symptoms have so